論文

国際誌
2021年11月

Preventative effects of bisoprolol transdermal patches on postoperative atrial fibrillation in high-risk patients undergoing non-cardiac surgery: A subanalysis of the MAMACARI study.

Journal of cardiology
  • Takayuki Iwano
  • Hironobu Toda
  • Kazufumi Nakamura
  • Kazuyoshi Shimizu
  • Kentaro Ejiri
  • Yoichiro Naito
  • Hisatoshi Mori
  • Takuro Masuda
  • Toru Miyoshi
  • Masashi Yoshida
  • Yukiko Hikasa
  • Hiroshi Morimatsu
  • Hiroshi Ito
  • 全て表示

78
5
開始ページ
349
終了ページ
354
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jjcc.2021.05.001

BACKGROUND: Perioperative atrial fibrillation (POAF) after non-cardiac surgery is a risk factor for cardiovascular events including stroke and death. The aim of this subanalysis of the MAMACARI study, a multicenter randomized control study on the effectiveness of a bisoprolol transdermal patch for prevention of perioperative myocardial injury in high-risk patients undergoing non-cardiac surgery, was to identify the predictors of POAF after non-cardiac surgery in high-risk patients and to determine changes in blood pressure and heart rate during bisoprolol patch administration in the perioperative period. METHODS AND RESULTS: Patients aged over 60 years with hypertension and a high revised cardiac risk index (≥2) who were scheduled to undergo non-cardiac surgery were randomly assigned to a bisoprolol patch group (n = 120) or a control group (n = 120). We divided the patients into two groups: patients with POAF (POAF group; n = 16) and patients without POAF (non-POAF group; n = 206). Multivariate analysis showed that bisoprolol patch therapy (OR: 0.30, 95% CI: 0.092-0.978) and surgery time of 250 min or more (OR: 4.99, 95% CI: 1.37-18.2) were independently associated with POAF. Although systolic blood pressure did not differ significantly between the two groups throughout the perioperative period, treatment with a bisoprolol patch significantly reduced heart rate throughout the perioperative period compared with that in the control group. CONCLUSIONS: Low dose of a bisoprolol patch in the perioperative period was effective for prevention of POAF after non-cardiac surgery in high-risk patients, while long surgery time was an independent risk factor for POAF. It is expected that low dose of a bisoprolol patch can prevent POAF without causing hypotension.

リンク情報
DOI
https://doi.org/10.1016/j.jjcc.2021.05.001
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34083113
ID情報
  • DOI : 10.1016/j.jjcc.2021.05.001
  • PubMed ID : 34083113

エクスポート
BibTeX RIS