2004年8月
The semaphorin 4D receptor plexin-B1 is a GTPase activating protein for R-Ras
SCIENCE
- ,
- ,
- ,
- 巻
- 305
- 号
- 5685
- 開始ページ
- 862
- 終了ページ
- 865
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.1097545
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
Plexins are cell surface receptors for semaphorin molecules, and their interaction governs cell adhesion and migration in a variety of tissues. We report that the Semaphorin 4D (Sema4D) receptor Plexin-B1 directly stimulates the intrinsic guanosine triphosphatase ( GTPase) activity of R-Ras, a member of the Ras superfamily of small GTP-binding proteins that has been implicated in promoting cell adhesion and neurite outgrowth. This activity required the interaction of Plexin-B1 with Rnd1, a small GTP-binding protein of the Rho family. Down-regulation of R-Ras activity by the Plexin-B1-Rnd1 complex was essential for the Sema4D-induced growth cone collapse in hippocampal neurons. Thus, Plexin-B1 mediates Sema4D-induced repulsive axon guidance signaling by acting as a GTPase activating protein for R-Ras.
- リンク情報
- ID情報
-
- DOI : 10.1126/science.1097545
- ISSN : 0036-8075
- PubMed ID : 15297673
- Web of Science ID : WOS:000223104900048