2005年6月
Plexins: axon guidance and signal transduction
CELLULAR AND MOLECULAR LIFE SCIENCES
- ,
- ,
- 巻
- 62
- 号
- 12
- 開始ページ
- 1363
- 終了ページ
- 1371
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s00018-005-5018-2
- 出版者・発行元
- BIRKHAUSER VERLAG AG
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as semaphorins, ephrins and netrin. Plexins function as receptors for the repulsive axonal guidance molecules semaphorins. Intracellular domains of plexins are responsible for initiating cellular signal transduction inducing axon repulsion. Recent advances have revealed molecular mechanisms for plexin-mediated cytoskeletal reorganization, leading to repulsive responses, and small GTPases play important roles in this signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. In this review we survey current understanding of the signaling mechanisms of plexins.
- リンク情報
- ID情報
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- DOI : 10.1007/s00018-005-5018-2
- ISSN : 1420-682X
- PubMed ID : 15818466
- Web of Science ID : WOS:000232496900010