Hiroshi Hibino

Profile Information

Affiliation: Graduate School of Medicine, Division of Medicine, Osaka University

Degree: (BLANK)

J-GLOBAL ID: 200901083458185108
researchmap Member ID: 1000281952

External link: https://www.med.niigata-u.ac.jp/ph2/welcome.html

Research Interests

Research Areas

Research History

Jan, 2021 - Present

Graduate School of Medicine, Osaka University
2010 - Dec, 2020

Niigata University Graduate School of Medical and Dental Sciences, Course of Biological Functions and Medical Control
Feb, 2007 - 2010

Associate Professor, Department of Pharmacology, Division of Molecular and Cellular Pharmacology, Graduate School of Medicine, Osaka University
1999 - 2007

Assistant Professor, Department of Pharmacology, Faculty of Medicine and Graduate School of Medicine, Osaka University
2007

-: - Graduate School of Medicine, Osaka University, Associate Professor
1999 - 2002

Research Associate, Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University

Papers

129

Classification of multiple emotional states from facial expressions in head-fixed mice using a deep learning-based image analysis

Yudai Tanaka, Takuto Nakata, Hiroshi Hibino, Masaaki Nishiyama, Daisuke Ino

PLOS ONE, 18(7) e0288930-e0288930, Jul 20, 2023 Peer-reviewed
A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip

Takuro Saiki, Genki Ogata, Seishiro Sawamura, Kai Asai, Olga Razvina, Kota Watanabe, Rito Kato, Qi Zhang, Koei Akiyama, Sasya Madhurantakam …

Heliyon, e15963-e15963, May, 2023 Peer-reviewedLast authorCorresponding author
A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain

Daisuke Ino, Yudai Tanaka, Hiroshi Hibino, Masaaki Nishiyama

Nature Methods, 19(10) 1286-1294, Oct, 2022 Peer-reviewed
Two Loci Contribute to Age-Related Hearing Loss Resistance in the Japanese Wild-Derived Inbred MSM/Ms Mice

Shumpei P. Yasuda, Yuki Miyasaka, Xuehan Hou, Yo Obara, Hiroshi Shitara, Yuta Seki, Kunie Matsuoka, Ai Takahashi, Eri Wakai, Hiroshi Hibino …

Biomedicines, 10(9) 2221-2221, Sep 7, 2022 Peer-reviewed
A rapid and simple electrochemical detection of the free drug concentration in human serum using boron-doped diamond electrodes

Hideto Moriyama, Genki Ogata, Haruma Nashimoto, Seishiro Sawamura, Yoshiaki Furukawa, Hiroshi Hibino, Hiroyuki Kusuhara, Yasuaki Einaga

The Analyst, 147(20) 4442-4449, Sep, 2022 Peer-reviewed
In Vivo Real-Time Measurement of Drugs

Genki Ogata, Seishiro Sawamura, Kai Asai, Hiroyuki Kusuhara, Yasuaki Einaga, Hiroshi Hibino

Diamond Electrodes: Fundamentals and Applications, 227-236, Jan 1, 2022
A Method Designed for Point-of-care System Monitoring Plasma Concentration of an Anticancer Molecular Targeting Drug with Diamond Electrode

Takuro Saiki, Ogata Genki, Sawamura Seishiro, Razvina Olga, Watanabe Kota, Kato Rito, Asai Kai, Matsumoto Yoshifumi, Moriyama Masato, Saijo Yasuo …

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 2-YIA-58, 2022
A prototype of the microsensing system for in vivo drug monitoring in the skin with diamond electrode

Ahmad Norzahirah Binti, Sawamura Seishiro, Ogata Genki, Einaga Yasuaki, Hibino Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 1-B-SS04-6, 2022
Sparsity-aware OCT volumetric data restoration using optical synthesis model.

Kobayashi R, Fujii G, Yoshida Y, Ota T, Nin F, Hibino H, Choi S, Ono S, Muramatsu S

IEEE Trans Comput Imagin, 8 505-520, 2022 Peer-reviewed
Author Correction: Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports.

Fumiaki Nin, Takamasa Yoshida, Shingo Murakami, Genki Ogata, Satoru Uetsuka, Samuel Choi, Katsumi Doi, Seishiro Sawamura, Hidenori Inohara, Shizuo Komune …

NPJ systems biology and applications, 7(1) 39-39, Oct 18, 2021 Peer-reviewedLast authorCorresponding author
Electrochemical properties of the non-excitable tissue stria vascularis of the mammalian cochlea are sensitive to sounds.

Qi Zhang, Takeru Ota, Takamasa Yoshida, Daisuke Ino, Mitsuo P Sato, Katsumi Doi, Arata Horii, Fumiaki Nin, Hiroshi Hibino

The Journal of Physiology, 599(19) 4497-4516, Aug 23, 2021 Peer-reviewedLast authorCorresponding author
Rapid optical tomographic vibrometry using a swept multi-gigahertz comb

Samuel Choi, Takeru Ota, Fumiaki Nin, Tatsutoshi Shioda, Takamasa Suzuki, Hiroshi Hibino

Optics Express, 29(11) 16749-16749, May 24, 2021 Peer-reviewedLast author
Analysis of Pharmacokinetics in the Cochlea of the Inner Ear

Seishiro Sawamura, Genki Ogata, Kai Asai, Olga Razvina, Takeru Ota, Qi Zhang, Sasya Madhurantakam, Koei Akiyama, Daisuke Ino, Sho Kanzaki …

Frontiers in Pharmacology, 12, May 3, 2021 Peer-reviewedLast authorCorresponding author
Optimization of spectral-domain optical coherence tomography with a supercontinuum source for in vivo motion detection of low reflective outer hair cells in guinea pig cochleae

Fumiaki Nin, Samuel Choi, Takeru Ota, Zhang Qi, Hiroshi Hibino

Optical Review, 28(2) 239-254, Apr, 2021 Peer-reviewedLast author
Perinatal Epidermal Growth Factor Signal Perturbation Results in the Series of Abnormal Auditory Oscillations and Responses Relevant to Schizophrenia

Hiroyoshi Inaba, Ryota Kai, Hisaaki Namba, Hidekazu Sotoyama, Eiichi Jodo, Fumiaki Nin, Hiroshi Hibino, Hirooki Yabe, Satoshi Eifuku, Arata Horii …

Schizophrenia Bulletin Open, 2(1), Jan 1, 2021 Peer-reviewed
がんオーダーメイド治療に貢献するポータブル血中「薬物」濃度測定器の創出

緒方元気, 椎木弘, 高井まどか, 楠原洋之, 栄長泰明, 日比野浩

福田記念医療技術振興財団情報, (33) 97-104, Dec, 2020
がんオーダーメイド治療に貢献するポータブル血中「薬物」濃度測定器の創出

緒方元気, 椎木弘, 高井まどか, 楠原洋之, 栄長泰明, 日比野浩

福田記念医療技術振興財団情報, (33) 97-104, Dec, 2020
分子インプリンティングによる機能性微小プローブの開発

孫術益, 岩本晃太, 田邊壮, 緒方元気, 日比野浩, 椎木弘

日本分析化学会講演要旨集, 69年会 188-188, Sep, 2020
In Vivo Real-Time Simultaneous Examination of Drug Kinetics at Two Separate Locations Using Boron-Doped Diamond Microelectrodes.

Ai Hanawa, Genki Ogata, Seishiro Sawamura, Kai Asai, Sho Kanzaki, Hiroshi Hibino, Yasuaki Einaga

Analytical Chemistry, 92(20) 13742-13749, Aug 27, 2020 Peer-reviewedCorresponding author
Characterisation of the static offset in the travelling wave in the cochlear basal turn

Takeru Ota, Fumiaki Nin, Samuel Choi, Shogo Muramatsu, Seishiro Sawamura, Genki Ogata, Mitsuo P. Sato, Katsumi Doi, Kentaro Doi, Tetsuro Tsuji …

Pflügers Archiv - European Journal of Physiology, 472(5) 625-635, May, 2020 Peer-reviewedLast authorCorresponding author

Misc.

163

針状ダイヤモンド電極を駆使した脳の薬物モニタリングシステムの創出—Development of an advanced drug monitoring system for the brain with needle-type diamond electrode—研究者の最新動向

澤村晴志朗, 緒方元気, 栄長泰明, 日比野浩

Precision medicine = プレシジョンメディシン / 「Precision medicine」編集委員会編, 5(7) 645-647, Jul, 2022
生体からインフラ分野まで応用できる非接触・形状・断層・振動計測技術

崔森悦, 日比野浩

JETI, 69(6) 53-57, 2021 InvitedLast author
A strategy for rapid and easy measurement of plasma concentration of pazopanib

緒方元気, 齋木琢郎, 齋木琢郎, 澤村晴志朗, RAZVINA Olga, 渡邉航太, 加藤理都, 浅井開, 花輪藍, 松本吉史 …

日本生体医工学会大会プログラム・抄録集(Web), 60th, 2021
ダイヤモンド電極を用いた電気化学測定による薬物血中濃度の迅速測定

齋木琢郎, 齋木琢郎, 緒方元気, 澤村晴志朗, ラズビナオリガ, 渡邊航太, 加藤里都, 浅井開, 松本吉史, 森山雅人 …

日本生理学雑誌(Web), 83(2), 2021
音ってどうやって聴こえるの？

日比野浩, 太田岳

36(10) 4-9, 2020 Lead authorCorresponding author
感音難聴治療のための聴覚生理の新知見

任書晃, 太田岳, 日比野浩

JOHNS, 36(1) 10-14, 2020 InvitedLast authorCorresponding author
てんかん治療に資する新規薬物センサシステムの開発

澤村晴志郎, 緒方元気, 栄長泰明, 日比野浩

BIO Clinica, 35(8) 763-766, 2020 InvitedLast authorCorresponding author
生体振動のen-face可視化：内耳感覚上皮帯の振動を見る光断層振動撮像顕微鏡

崔森悦, 任書晃, 太田岳, 佐藤洸平, 村松正吾, 日比野浩

光学, 49(6) 247, 2020 InvitedLast author
Optical coherence microscope using high-speed CMOS image sensor for intracochlear vibration imaging

CHOI Samuel, 村松正吾, 任書晃, 太田岳, 日比野浩

映像情報メディア学会技術報告, 44(29(IST2020 43-51)), 2020
Detection of an atypical motion in cochlear sensory epithelium

Ota T, Nin F, Choi S, Hibino H

The Journal of Physiological Science, Supplement(1), 69 S17-S17, Jun, 2019 Peer-reviewed
An imaging system for 3D detection of nano-vibrations in sensory epithelium of the inner ear

Nin F, Choi S, Ota T, Hibino H

The Journal of Physiological Science, Supplement(1), 69 S157-S157, Jun, 2019 Peer-reviewed
Analysis of nanoscale vibrations in the inner ear by advanced vibrometries.

Hibino H, Ota T, Choi S, Nin F

The Journal of Physiological Science, Supplement(1), 69 S88-S88, Jun, 2019 Peer-reviewed
最先端プローブによる細胞外微小環境のシグナル計測序文

日比野浩

日本薬理学雑誌, 153 253-253, Jun, 2019
針状ダイヤモンド微小電極を駆使した生体内薬物センシングシステムの創出.

日比野浩

日本薬理学雑誌, 153 273-277, Jun, 2019
多波長走査型光コヒーレンス顕微鏡とスパースモデリングによる内耳感覚上皮帯ボリュームデータの3次元画像復元

CHOI Samuel, CHOI Samuel, 村松正吾, 村松正吾, 太田岳, 太田岳, 任書晃, 任書晃, 鈴木孝昌, 日比野浩 …

応用物理学会秋季学術講演会講演予稿集(CD-ROM), 80th, 2019
薬物の濃度と作用を生体内の局所でリアルタイム計測する新技術

日比野浩, 緒方元気, 浅井開, 楠原洋之, 栄長泰明

日本生体医工学会大会プログラム・抄録集(Web), 58th(Abstract) ROMBUNNO.SY‐087 (WEB ONLY)-S222_2, 2019
[Development of in vivo drug sensing system with needle-type diamond microelectrode].

Ogata G, Asai K, Sano Y, Sawamura S, Takai M, Kusuhara H, Einaga Y, Hibino H

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153(6) 273-277, 2019 Peer-reviewed
内耳感覚上皮帯のナノ振動

太田岳, 任書晃, 日比野浩

Clinical Neuroscience, 37(12) 1479-1480, 2019
内耳蝸牛を標的にした針状ダイヤモンドセンサによる薬物動態のin vivoリアルタイム測定

緒方元気, 栄長泰明, 日比野浩

Otology Japan, 28(4) 487, Sep 12, 2018
生体内局所の薬物の濃度と作用の変動を同時計測するマイクロセンシングシステムの創出

緒方元気, 緒方元気, 浅井開, 佐野大和, 高井まどか, 楠原洋之, 栄長泰明, 栄長泰明, 日比野浩, 日比野浩

日本生体医工学会大会プログラム・抄録集(Web), 57th ROMBUNNO.O1‐6‐5‐5 (WEB ONLY), Jun 19, 2018

Books and Other Publications

Cell Physiology Sourcebook: A molecular approach, Third Edition.

HIBINO Hiroshi (Role: Contributor, Regulation of ion channels by membrane proteins and cytoskeleton.)

Academic Press, 2001
Current Topics in Membranes, Vol. 46, Potassium ion channel: molecular, structure, function and disease

Hibino H, Terzic A, Inanobe A, Horio Y, Kurachi Y (Role: Contributor, Regulation of ion channels by membrane proteins)

Academic Press, 1999
Ion Channels: from structure to function.

Hibino H, Kurachi Y (Role: Contributor, Kir1, Kir2, Kir4, Kir5 and Kir7 families)

Oxford University Press

Professional Memberships

Works

Research Projects

加齢性難聴の克服に資する病態解明と次世代型医療の基盤技術の創出

AMED-CREST 革新的先端研究開発支援事業, 国立研究開発法人日本医療研究開発機構, Oct, 2021 - Mar, 2027
Establishment of comprehensive monitoring of direct oral anticoagulants (DOACs) for clinical application

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
脳-感覚器連関に着目したアルツハイマー病における臓器間ネットワークの解明と非侵襲的センシング・介入基盤技術の開発

JST ムーンショット型研究開発事業, 国立研究開発法人科学技術振興機構, Apr, 2021 - Mar, 2026
ダイヤモンド電極法を用いた血中薬物濃度測定に基づくパゾパニブ服用患者の観察研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

齋木琢郎, 西條康夫, 日比野浩, 緒方元気, 栄長泰明
Development of a handy system for rapid drug monitoring from tiny amounts of blood

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
高度難聴の内耳病態の解明ーヒト蝸牛外リンパに発現する蛋白質の網羅的解析

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

土井勝美, 日比野浩
The current state of higher education in Russia and challenges of Japan-Russia international exchange

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Development of blood monitoring method for direct oral anticoagulant (DOAC)

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Development of an implantable sensory system that can approach safe and effective therapeutic interventions for neuropsychiatric disorders

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Hibino Hiroshi
Development of optical tomographic imaging system for in-vivo nano-vibration measurement of whole 3D structure in biological tissue

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Choi Samuel
高次元信号復元・予測のための構造化畳み込みネットワーク

基盤研究(B), Apr, 2019 - Mar, 2022

村松正吾
難聴モデル動物の病態解明を施行した内耳ナノ振動の新規計測プラットフォーム

基盤研究(B), Apr, 2018 - Mar, 2022

任書晃
オーダーメイド治療に貢献するポータブル血中「薬物」濃度測定器の創出

基盤研究(B), Apr, 2018 - Mar, 2022

緒方元気
Establishment and applications of model mice with fluctuated deafness by advanced gene-engineering methods

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Hibino Hiroshi
An implantable drug-sensing system that contributes to safe and effective therapy for epilepsy

Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows, Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021
Measurement platform of nano-vibration in the cochlea for understanding the pathogenesis in deafness model mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Nin Fumiaki
内リンパ水腫の分子機構の解明―内リンパ嚢に発現する蛋白質の網羅的解析

基盤研究(C), Apr, 2018 - Mar, 2021

土井勝美
内耳による音のナノ振動の受容・応答機構の解明と難聴治療への展開

革新的先端研究開発支援事業（AMED-CREST）, Dec, 2015 - Mar, 2021

日比野浩
Electrophysiological analysis of fibrocytes of the spiral ligament in the inner ear

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Yoshida Takamasa, NAKAGAWA Takashi, HIBINO Hiroshi, NIN Fumiaki, OGATA Genki
筋ジストロフィーモデルマウスで発症する難聴のメカニズムの理解

平成28年度神戸大学バイオシグナル総合研究センター共同利用研究, Apr, 2016 - Mar, 2019

日比野浩

Industrial Property Rights

特願2019-193880 難聴の予防および／または治療用医薬組成物

永田, 森, 日比野, 澤村晴志, 任書晃

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Research Interests

Research Areas

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Papers

Misc.

Books and Other Publications

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Research Projects

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