2012年
Alkadienyl and alkenyl itaconic acids (ceriporic acids G and H) from the selective white-rot fungus Ceriporiopsis subvermispora: a new class of metabolites initiating ligninolytic lipid peroxidation
ORGANIC & BIOMOLECULAR CHEMISTRY
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- 巻
- 10
- 号
- 31
- 開始ページ
- 6432
- 終了ページ
- 6442
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c2ob25415h
- 出版者・発行元
- ROYAL SOC CHEMISTRY
New ceriporic acids-alkadienyl and alkenyl itaconic acids having a bis-allyl (3-[(Z,Z)-hexadec-7,10-dienyl]-itaconic acid; ceriporic acid G) and a monoene (3-[(Z)-octadec-9-enyl]-itaconic acid; ceriporic acid H) structure in their side chains-were isolated from the cultures of the selective lignin-degrading fungus Ceriporiopsis subvermispora. The new metabolites ceriporic acid G and H were synthesized by a cross-aldol condensation and a Grignard substitution reaction, respectively. Ceriporic acid G triggered the manganese peroxidase (MnP)-catalyzed lipid peroxidation and decomposed a recalcitrant non-phenolic lignin substructure model compound. Except for simple fatty acids, this is the first report of a fungal metabolite that induced ligninolytic lipid peroxidation.
- リンク情報
- ID情報
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- DOI : 10.1039/c2ob25415h
- ISSN : 1477-0520
- PubMed ID : 22739503
- Web of Science ID : WOS:000306480100022