2015年4月21日
Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
Immunity
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 42
- 号
- 4
- 開始ページ
- 692
- 終了ページ
- 703
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.immuni.2015.03.008
The interleukin-17 (IL-17) family of cytokines has emerged as a critical player in inflammatory diseases. Among them, IL-25 has been shown to be important in allergic inflammation and protection against parasitic infection. Here we have demonstrated that IL-17B, a poorly understood cytokine, functions to inhibit IL-25-driven inflammation. IL-17B and IL-25, both binding to the interleukin-17 receptor B (IL-17RB), were upregulated in their expression after acute colonic inflammation. Individual inhibition of these cytokines revealed opposing functions in colon inflammation: IL-25 was pathogenic but IL-17B was protective. Similarly opposing phenotypes were observed in Citrobacter rodentium infection and allergic asthma. Moreover, IL-25 was found to promote IL-6 production from colon epithelial cells, which was inhibited by IL-17B. Therefore, our data demonstrate that IL-17B is an anti-inflammatory cytokine in the IL-17 family.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.immuni.2015.03.008
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/25888259
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811222
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000353347500015&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1016/j.immuni.2015.03.008
- ISSN : 1074-7613
- PubMed ID : 25888259
- PubMed Central 記事ID : PMC5811222
- Web of Science ID : WOS:000353347500015