2012年2月
Development and Function of Invariant Natural Killer T Cells Producing T(H)2- and T(H)17-Cytokines
PLOS BIOLOGY
- 巻
- 10
- 号
- 2
- 開始ページ
- e1001255
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.pbio.1001255
- 出版者・発行元
- PUBLIC LIBRARY SCIENCE
There is heterogeneity in invariant natural killer T (iNKT) cells based on the expression of CD4 and the IL-17 receptor B (IL-17RB), a receptor for IL-25 which is a key factor in T(H)2 immunity. However, the development pathway and precise function of these iNKT cell subtypes remain unknown. IL-17RB(+) iNKT cells are present in the thymic CD44(+/-) 2 NK1.1(-) population and develop normally even in the absence of IL-15, which is required for maturation and homeostasis of IL-17RB(-) iNKT cells producing IFN-gamma. These results suggest that iNKT cells contain at least two subtypes, IL-17RB(+) and IL-17RB(-) subsets. The IL-17RB(+) iNKT subtypes can be further divided into two subtypes on the basis of CD4 expression both in the thymus and in the periphery. CD4(+) IL-17RB(+) iNKT cells produce T(H)2 (IL-13), T(H)9 (IL-9 and IL-10), and T(H)17 (IL-17A and IL-22) cytokines in response to IL-25 in an E4BP4-dependent fashion, whereas CD4(-) IL-17RB(+) iNKT cells are a retinoic acid receptor-related orphan receptor (ROR)gamma t(+) subset producing T(H)17 cytokines upon stimulation with IL-23 in an E4BP4-independent fashion. These IL-17RB(+) iNKT cell subtypes are abundantly present in the lung in the steady state and mediate the pathogenesis in virus-induced airway hyperreactivity (AHR). In this study we demonstrated that the IL-17RB(+) iNKT cell subsets develop distinct from classical iNKT cell developmental stages in the thymus and play important roles in the pathogenesis of airway diseases.
- リンク情報
- ID情報
-
- DOI : 10.1371/journal.pbio.1001255
- ISSN : 1544-9173
- PubMed ID : 22346732
- Web of Science ID : WOS:000300951500001