論文

査読有り
2017年7月

Design of Novel Hydrogen-Bonding Donor Organocatalysts and Their Application to Asymmetric Direct Aldol Reaction

SYNLETT
  • Hiroshi Akutsu
  • ,
  • Kosuke Nakashima
  • ,
  • Hikaru Yanai
  • ,
  • Akira Kotani
  • ,
  • Shin-ichi Hirashima
  • ,
  • Tomoyuki Yamamoto
  • ,
  • Ryuta Takahashi
  • ,
  • Akihiro Yoshida
  • ,
  • Yuji Koseki
  • ,
  • Hideki Hakamata
  • ,
  • Takashi Matsumoto
  • ,
  • Tsuyoshi Miura

28
11
開始ページ
1363
終了ページ
1367
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1055/s-0036-1558971
出版者・発行元
GEORG THIEME VERLAG KG

Asymmetric catalytic activities of various organocatalysts bearing double hydrogen-bonding donor units showing different pK(a) values were examined for direct aldol reactions of cyclohexanone with aromatic aldehydes. Organocatalyst with motif exhibiting the highest acidity resulted in the corresponding aldol products with the highest enantioselectivity. A good correlation has been observed between the asymmetric catalytic activity for direct aldol reactions and acidities of double hydrogen-bonding donating units.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1055/s-0036-1558971
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000404001700028&DestApp=WOS_CPL
ID情報
  • DOI : 10.1055/s-0036-1558971
  • ISSN : 0936-5214
  • eISSN : 1437-2096
  • Web of Science ID : WOS:000404001700028

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