論文

2021年3月30日

Gold-Etched Silver Nanowire Endoscopy: Toward a Widely Accessible Platform for Surface-Enhanced Raman Scattering-Based Analysis in Living Cells

Analytical Chemistry
  • Monica Ricci
  • ,
  • Beatrice Fortuni
  • ,
  • Raffaele Vitale
  • ,
  • Qiang Zhang
  • ,
  • Yasuhiko Fujita
  • ,
  • Shuichi Toyouchi
  • ,
  • Gang Lu
  • ,
  • Susana Rocha
  • ,
  • Tomoko Inose
  • ,
  • Hiroshi Uji-i

93
12
開始ページ
5037
終了ページ
5045
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1021/acs.analchem.0c04120
出版者・発行元
American Chemical Society (ACS)

Recently, our group introduced the use of silver nanowires (AgNWs) as novel non-invasive endoscopic probes for detecting intracellular Raman signals. This method, although innovative and promising, relies exclusively on the plasmonic waveguiding effect for signal enhancement. It, therefore, requires sophisticated operational tools and protocols, drastically limiting its applicability. Herein, an advanced strategy is offered to significantly enhance the performance of these endoscopic probes, making this approach widely accessible and versatile for cellular studies. By uniformly forming gold structures on the smooth AgNW surface via a galvanic replacement reaction, the density of the light coupling points along the whole probe surface is drastically increased, enabling high surface-enhanced Raman scattering (SERS) efficiency upon solely focusing the excitation light on the gold-etched AgNW. The applicability of these gold-etched AgNW probes for molecular sensing in cells is demonstrated by detecting site-specific and high-resolved SERS spectra of cell compartment-labeling dyes, namely, 4',6-diamidino-2-phenylindole in the nucleus and 3,3'-dioctadecyloxacarbocyanine on the membrane. The remarkable spectral sensitivity achieved provides essential structural information of the analytes, indicating the overall potential of the proposed approach for cellular studies of drug interactions with biomolecular items.

リンク情報
DOI
https://doi.org/10.1021/acs.analchem.0c04120
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000636602500008&DestApp=WOS_CPL
URL
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.0c04120
ID情報
  • DOI : 10.1021/acs.analchem.0c04120
  • ISSN : 0003-2700
  • eISSN : 1520-6882
  • Web of Science ID : WOS:000636602500008

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