2022年9月
Intradermal measurement of reactive oxygen species using open-tip porous microneedles
Microelectronic Engineering
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- 巻
- 265
- 号
- 開始ページ
- 111877
- 終了ページ
- 111877
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.mee.2022.111877
- 出版者・発行元
- Elsevier BV
Reactive oxygen species (ROS), which constitute a representative group of substances associated with skin health, are promising indicators of oxidative stress. A local electrochemical system can measure ROS with minimal invasiveness. In this study, a microneedle-based amperometric sensor is developed for real-time monitoring of changes in the H2O2 concentration of the skin. Two electrodes can be mounted on a single open-tip porous microneedle (PMN), which allows local measurement without intradermal noise caused by the high resistance and non-uniform distribution of the potential difference. The PMN electrode shows a current response in accordance with the H2O2 concentration, and amperometric measurement of ex vivo skin samples is successfully performed. The results indicate that a compact system based on a single needle is a promising tool for intracutaneous sensing of biological signals.
- リンク情報
- ID情報
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- DOI : 10.1016/j.mee.2022.111877
- ISSN : 0167-9317
- SCOPUS ID : 85138021066