hiroyuki sakagami - My portal

Profile Information

Affiliation: -

Degree: 医学博士(東北大学大学院)

J-GLOBAL ID: 201101056850775003
researchmap Member ID: B000002429

External link: http://www.med.kitasato-u.ac.jp/~sakagami/index.php?FrontPage

Research Interests

Research Areas

Research History

2007 - 2009

School of Medicine, Kitasato University
2001 - 2007

助教授, 東北大学医学(系)研究科(研究院)
2006

Graduate School of Medicine, Tohoku University
2001 - 2005

助教授, 東北大学医学系研究科・大学院
2000

助教授, 東北大学医学系研究科
1999

助教授, 東北大学医学系研究科・大学院
1999

Faculty of Medicine, Tohoku University
1995 - 1998

Faculty of Medicine, Tohoku University
1998

Faculty of Medicine, Tohoku University

Papers

112

CMT type 2N disease-associated AARS mutant inhibits neurite growth that can be reversed by valproic acid.

Yuriko Tatsumi, Naoto Matsumoto, Noriko Iibe, Natsumi Watanabe, Tomohiro Torii, Kazunori Sango, Keiichi Homma, Yuki Miyamoto, Hiroyuki Sakagami, Junji Yamauchi

Neuroscience research, 139 69-78, Feb, 2019 Peer-reviewed
Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene.

Keietsu Kikuchi, Daisuke Ihara, Mamoru Fukuchi, Hiroki Tanabe, Yuta Ishibashi, Junya Tsujii, Masaaki Tsuda, Marisa Kaneda, Hiroyuki Sakagami, Hiroyuki Okuno …

Journal of neurochemistry, 148(2) 204-218, Jan, 2019 Peer-reviewed
FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation.

Yoshinobu H, Masahiro F, Sugawara T, Sakagami H

The European journal of neuroscience, Oct, 2018 Peer-reviewed
Pull down assay for GTP-bound form of Sar1a reveals its activation during morphological differentiation.

Yuri Urai, Minami Yamawaki, Natsumi Watanabe, Yoich Seki, Takako Morimoto, Kenji Tago, Keiichi Homma, Hiroyuki Sakagami, Yuki Miyamoto, Junji Yamauchi

Biochemical and biophysical research communications, 503(3) 2047-2053, Sep 10, 2018 Peer-reviewed
Pallidin is a novel interacting protein for cytohesin-2 and regulates the early endosomal pathway and dendritic formation in neurons.

Ito A, Fukaya M, Saegusa S, Kobayashi E, Sugawara T, Hara Y, Yamauchi J, Okamoto H, Sakagami H

Journal of neurochemistry, 147(2) 153-177, Aug, 2018 Peer-reviewed
Localization of EFA6 (exchange factor for ARF6) isoform D in steroidogenic testicular Leydig cells of adult mice

Surang Chomphoo, Sawetree Pakkarato, Tarinee Sawatpanich, Hiroyuki Sakagami, Hisatake Kondo, Wiphawi Hipkaeo

Acta Histochemica, 120(3) 263-268, Apr 1, 2018 Peer-reviewed
Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.

Shigeki Moriguchi, Satomi Kita, Masahiro Fukaya, Makoto Osanai, Ryo Inagaki, Yuzuru Sasaki, Hisanao Izumi, Kyoji Horie, Junji Takeda, Takashi Saito …

Neuropharmacology, 131 291-303, Mar 15, 2018 Peer-reviewed
Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology.

Marisa Kaneda, Hiroyuki Sakagami, Yamato Hida, Toshihisa Ohtsuka, Natsumi Satou, Yuta Ishibashi, Mamoru Fukuchi, Anna Krysiak, Mitsuru Ishikawa, Daisuke Ihara …

Scientific reports, 8(1) 727-727, Jan 15, 2018 Peer-reviewed
Cellular and subcellular localization of ADP-ribosylation factor 6 in mouse peripheral tissues

Osamu Katsumata, Momoko Mori, Yusuke Sawane, Tomoko Niimura, Akiko Ito, Hirotsugu Okamoto, Masahiro Fukaya, Hiroyuki Sakagami

HISTOCHEMISTRY AND CELL BIOLOGY, 148(6) 577-596, Dec, 2017 Peer-reviewed
Data on the effect of knockout of cytohesin-1 in myelination-related protein kinase signaling

Ruri Tsuneishi, Naoto Matsumoto, Misa Itaoka, Yuri Urai, Minami Kaneko, Natsumi Watanabe, Shou Takashima, Yoichi Seki, Takako Morimoto, Hiroyuki Sakagami …

Data in Brief, 15 234-239, Dec 1, 2017 Peer-reviewed
A glycine transporter 2-Cre knock-in mouse line for glycinergic neuron-specific gene manipulation

Toshikazu Kakizaki, Hiroyuki Sakagami, Kenji Sakimura, Yuchio Yanagawa

IBRO Reports, 3 9-16, Dec 1, 2017 Peer-reviewed
Co-localization of endogenous Arf6 and its activator EFA6D in the granular convoluted tubule cells of mouse submandibular glands under normal conditions and when stimulated by isoproterenol, noradrenaline and carbachol

Apussara Tachow, Wipawee Thoungseabyoun, Laorrat Phuapittayalert, Kanoktip Petcharat, Hiroyuki Sakagami, Hisatake Kondo, Wiphawi Hipkaeo

ARCHIVES OF ORAL BIOLOGY, 82 153-159, Oct, 2017 Peer-reviewed
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.

Kosuke Okuda, Shizuka Kobayashi, Masahiro Fukaya, Aya Watanabe, Takuto Murakami, Mai Hagiwara, Tempei Sato, Hiroe Ueno, Narumi Ogonuki, Sayaka Komano-Inoue …

Neurobiology of disease, 106 158-170, Oct, 2017 Peer-reviewed
BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal

Hiroyuki Sakagami, Osamu Katsumata, Yoshinobu Hara, Toshikuni Sasaoka, Masahiro Fukaya

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(9) 3795-3803, Jul, 2017 Peer-reviewed
Regulation of visual Wulst cell responsiveness by imprinting causes stimulus-specific activation of rostral cells

Tomoharu Nakamori, Tomomi Kato, Hiroyuki Sakagami, Kohichi Tanaka, Hiroko Ohki-Hamazaki

SCIENTIFIC REPORTS, 7 42927, Feb, 2017 Peer-reviewed
Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain

Rie Kusano, Kousuke Fujita, Yasuharu Shinoda, Yuko Nagaura, Hiroshi Kiyonari, Takaya Abe, Toshio Watanabe, Yasuhisa Matsui, Masahiro Fukaya, Hiroyuki Sakagami …

FEBS LETTERS, 590(20) 3606-3615, Oct, 2016 Peer-reviewed
Distinct subcellular localization of alternative splicing variants of EFA6D, a guanine nucleotide exchange factor for Arf6, in the mouse brain

Masahiro Fukaya, Shingo Ohta, Yoshinobu Hara, Hideaki Tamaki, Hiroyuki Sakagami

JOURNAL OF COMPARATIVE NEUROLOGY, 524(13) 2531-2552, Sep, 2016 Peer-reviewed
Interaction of serologically defined colon cancer antigen-3 with Arf6 and its predominant expression in the mouse testis

Hiroyuki Sakagami, Yoshinobu Hara, Masahiro Fukaya

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 477(4) 868-873, Sep, 2016 Peer-reviewed
Expression of Beta Subunit 2 of Ca²+/Calmodulin-Dependent Protein Kinase I in the Developing Rat Retina.

Jusuf AA, Sakagami H, Kikkawa S, Terashima T

The Kobe journal of medical sciences, 61(4) E115-23, Mar, 2016 Peer-reviewed
Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance

Hiroshi Tanahashi, Qing-Bao Tian, Yoshinobu Hara, Hiroyuki Sakagami, Shogo Endo, Tatsuo Suzuki

SCIENTIFIC REPORTS, 6 20241, Feb, 2016 Peer-reviewed

Misc.

Redundant and distinct functions of three ras genes(1)

NAKAMURA Kenji, ICHISE Hirotake, NAKAO Kazuki, AIBA Atsu, HATTA Toshihisa, OTANI Hiroshi, SAKAGAMI Hiroyuki, KONDO Hisatake, KOERA Keiko, ISE Kazuhiro …

21 514-514, Dec 1, 1998
Expression and functional analyses of novel protein kinases isolated from mouse PGC-specific cDNA library

UEDA Takahiro, SAKAGAMI Hiroyuki, ABE Kuniya, MARUO Akihiro, OISHI Isao, SUGIYAMA Shin, YAMAMURA Hirohei, MINAMI Yasuhiro

21 613-613, Dec 1, 1998
Ca^<2+>/カルモデュリン依存性プロテインキナーゼIV型の遺伝子組織化学的研究

阪上洋行

東北医学雑誌, 110(1) 43-45, Aug, 1998

Teaching Experience

Professional Memberships

Research Projects

低分子量G蛋白質Arf6経路に着目した網膜リボンシナプスの分子解剖学

基盤研究(B), 日本学術振興会, Apr, 2015 - Mar, 2019

阪上洋行
脆弱X症候群のmGluR発症仮説におけるArf6経路の新たな役割

挑戦的萌芽研究, 文部科学省, Apr, 2013 - Mar, 2015

阪上洋行
抑制性シナプスの新たな制御経路としての低分子量Ｇ蛋白質ＡＲＦ６の機能解明

基盤研究(B), 日本学術振興会, Apr, 2010 - Mar, 2014

阪上洋行
ARF6による神経細胞移動とがん細胞浸潤の制御機構の共通性と特異性の解明

挑戦的萌芽研究, 文部科学省, Apr, 2011 - Mar, 2013

阪上洋行
低分子量G蛋白質ARF6の細胞の形づくりへの普遍的機能関与と分子機構の解明

科学研究費補助金(挑戦的萌芽研究), 挑戦的萌芽研究, 文部科学省, 2009 - 2009

阪上洋行
Mechanisms for the dendritic formation by ADP ribosylation factor 6 and its functional significance in higher brain functions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

SAKAGAMI Hiroyuki
Analysis of Novel Cellular Functions of Fatty Acid Binding Proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2006 - 2007

KONDO Hisatake, OWADA Yuji, SAKAGAMI Hiroyuki
Targeting mechanisms for calmodulin-dependent protein kinases and their neuronal functions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

SAKAGAMI Hiroyuki
海馬神経細胞の新生におけるカルモデュリンキナーゼIVの機能解明

科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2004 - 2004

阪上洋行
シナプス可塑性におけるカルモデュリンキナーゼの動的な機能発現の場の可視化

科学研究費補助金(若手研究(B)), 若手研究(B), 文部科学省, 2003 - 2004

阪上洋行
Functional analysis of fatty acid binding proteins in immune and neural tissues.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2003

KONDO Hisatake, OWADA Yuji, SAKAGAMI Hiroyuki
高次神経機能におけるカルモデュリンキナーゼIVの遺伝子欠損マウスを用いた機能解析

科学研究費補助金(奨励研究(A), 若手研究(B)), 奨励研究(A), 若手研究(B), 文部科学省, 2001 - 2002

阪上洋行
遺伝子欠損マウスを用いたカルモデュリンキナーゼIVの神経可塑性における機能解析

科学研究費補助金(特定領域研究(A)), 特定領域研究(A), 文部科学省, 2000 - 2000

齋野幸子
Molecular and Celluler Biological Analysis of the functional Significance of Phosphoinositide Metabolism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 1999 - 2000

KONDO Hisatake, OWADA Yuji, GOTO Kaoru, SAITO Sachiko, KANOH Hideo
Molecular and Cell Biological Analysis of lipid kinases and phosphatases involved in phosphoinosilide signaling

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1999 - 2000

KONDO Hisatake, SAITO Sachiko, OWADA Yuji
カルモデュリン依存性プロテインキナーゼIVの活性制御機構に関する形態学的解析

科学研究費補助金(奨励研究(A)), 奨励研究(A), 文部科学省, 1999 - 2000

阪上洋行
神経活動依存性遺伝子発現機構におけるカルモデュリンキナ-ゼIVの機能解析

科学研究費補助金(特定領域研究(A)), 特定領域研究(A), 文部科学省, 1998 - 1998
リピドキナ-ゼの分子生物学的・遺伝子組織化学的研究

科学研究費補助金(国際学術研究), 国際学術研究, 文部科学省, 1997 - 1998
リピドキナ-ゼの情報伝達と小胞輸送への関与機序について分子・細胞生物学的解析

科学研究費補助金(基盤研究(B)), 基盤研究(B), 文部科学省, 1997 - 1998
Ca^<2+>/カルモデュリン依存性プロテインキナ-ゼIV欠損マウス作製と機能解析

科学研究費補助金(奨励研究(A)), 奨励研究(A), 文部科学省, 1997 - 1998