2018年
Membrane-active antimicrobial poly(amino-modified alkyl) β-cyclodextrins synthesized: Via click reactions
MedChemComm
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 9
- 号
- 3
- 開始ページ
- 509
- 終了ページ
- 518
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c7md00592j
- 出版者・発行元
- Royal Society of Chemistry
The emergence of drug-resistant bacteria has led to the high demand for new antibiotics. In this report, we investigated membrane-active antimicrobial β-cyclodextrins. These contain seven amino-modified alkyl groups on a molecule, which act as functional moieties to permeabilize bacterial cell membranes. The polyfunctionalization of cyclodextrins was achieved through a click reaction assisted by microwave irradiation. A survey using derivatives with systematically varied functionalities clarified the unique correlation of the antimicrobial activity of these compounds with their molecular structure and hydrophobicity/hydrophilicity balances. The optimum hydrophobicity for the compounds being membrane-active was specific to bacterial strains and animal cells
this led to specific compounds having selective toxicity against bacteria including multidrug-resistant pathogens. The results demonstrate that cyclodextrin is a versatile molecular scaffold for rationally designed structures and can be used for the development of new antibiotics.
this led to specific compounds having selective toxicity against bacteria including multidrug-resistant pathogens. The results demonstrate that cyclodextrin is a versatile molecular scaffold for rationally designed structures and can be used for the development of new antibiotics.
- リンク情報
- ID情報
-
- DOI : 10.1039/c7md00592j
- ISSN : 2040-2511
- ISSN : 2040-2503
- eISSN : 2040-2511
- ORCIDのPut Code : 43536599
- SCOPUS ID : 85044249794