Apr, 2013 - Mar, 2016
In situ monitoring of drug action using electrochemical sensors
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 25460036
- Japan Grant Number (JGN)
- JP25460036
- Grant amount
-
- (Total)
- 5,200,000 Japanese Yen
- (Direct funding)
- 4,000,000 Japanese Yen
- (Indirect funding)
- 1,200,000 Japanese Yen
We have developed a miniaturized acetylcholine sensor with high sensitivity and high selectivity and applied it to monitor changes in the concentration of acetylcholine in the hippocampus of awake mice in situ. Also, we have applied electrochemical sensors, such as a K+ sensor and an oxygen electrode, to analyze how porphyrin and chlorin dyes photoinactivate cell membranes. Furthermore, we have applied a K+ sensor to cell membrane permeability assay to clarify the action mechanism of antimicrobial cyclodextrin derivatives with low hemolytic activity and a new antibiotic, lysocin, that targets menaquinone in the bacterial membrane.
- Link information
- ID information
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- Grant number : 25460036
- Japan Grant Number (JGN) : JP25460036