Research Projects

Apr, 2013 - Mar, 2016

In situ monitoring of drug action using electrochemical sensors

Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

Grant number
25460036
Japan Grant Number (JGN)
JP25460036
Grant amount
(Total)
5,200,000 Japanese Yen
(Direct funding)
4,000,000 Japanese Yen
(Indirect funding)
1,200,000 Japanese Yen

We have developed a miniaturized acetylcholine sensor with high sensitivity and high selectivity and applied it to monitor changes in the concentration of acetylcholine in the hippocampus of awake mice in situ. Also, we have applied electrochemical sensors, such as a K+ sensor and an oxygen electrode, to analyze how porphyrin and chlorin dyes photoinactivate cell membranes. Furthermore, we have applied a K+ sensor to cell membrane permeability assay to clarify the action mechanism of antimicrobial cyclodextrin derivatives with low hemolytic activity and a new antibiotic, lysocin, that targets menaquinone in the bacterial membrane.

Link information
Kaken Url
https://kaken.nii.ac.jp/file/KAKENHI-PROJECT-25460036/25460036seika.pdf
KAKEN
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460036
ID information
  • Grant number : 25460036
  • Japan Grant Number (JGN) : JP25460036