論文

査読有り 筆頭著者 責任著者
2018年3月1日

CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties

Cell Stem Cell
  • Taku Wakabayashi
  • Hisamichi Naito (first & corresponding author)
  • Jun-ichi Suehiro
  • Yang Lin
  • Hideya Kawaji
  • Tomohiro Iba
  • Tsukasa Kouno
  • Sachi Ishikawa-Kato
  • Masaaki Furuno
  • Kazuhiro Takara
  • Fumitaka Muramatsu
  • Jia Weizhen
  • Hiroyasu Kidoya
  • Katsuhiko Ishihara
  • Yoshihide Hayashizaki
  • Kohji Nishida
  • Mervin C. Yoder
  • Nobuyuki Takakura
  • 全て表示

22
3
開始ページ
384
終了ページ
397.e6
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.stem.2018.01.010
出版者・発行元
Cell Press

The generation of new blood vessels via angiogenesis is critical for meeting tissue oxygen demands. A role for adult stem cells in this process remains unclear. Here, we identified CD157 (bst1, bone marrow stromal antigen 1) as a marker of tissue-resident vascular endothelial stem cells (VESCs) in large arteries and veins of numerous mouse organs. Single CD157+ VESCs form colonies in vitro and generate donor-derived portal vein, sinusoids, and central vein endothelial cells upon transplantation in the liver. In response to injury, VESCs expand and regenerate entire vasculature structures, supporting the existence of an endothelial hierarchy within blood vessels. Genetic lineage tracing revealed that VESCs maintain large vessels and sinusoids in the normal liver for more than a year, and transplantation of VESCs rescued bleeding phenotypes in a mouse model of hemophilia. Our findings show that tissue-resident VESCs display self-renewal capacity and that vascular regeneration potential exists in peripheral blood vessels. Whether tissue-resident vascular endothelial stem cells (VESCs) exist has remained unclear. The present study demonstrates that CD157 marks vessel-resident VESCs in mouse organs that are capable of clonal expansion, angiogenesis initiation, and blood vessel maintenance. These findings represent a paradigm shift in understanding endothelial cell hierarchy within the blood vessels.

リンク情報
DOI
https://doi.org/10.1016/j.stem.2018.01.010
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29429943
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85042586014&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85042586014&origin=inward
ID情報
  • DOI : 10.1016/j.stem.2018.01.010
  • ISSN : 1875-9777
  • ISSN : 1934-5909
  • eISSN : 1875-9777
  • PubMed ID : 29429943
  • SCOPUS ID : 85042586014

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