2012年2月
Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels
EMBO JOURNAL
- ,
- ,
- ,
- ,
- 巻
- 31
- 号
- 4
- 開始ページ
- 842
- 終了ページ
- 855
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/emboj.2011.465
- 出版者・発行元
- NATURE PUBLISHING GROUP
Vasculogenesis, the in-situ assembly of angioblast or endothelial progenitor cells (EPCs), may persist into adult life, contributing to new blood vessel formation. However, EPCs are scattered throughout newly developed blood vessels and cannot be solely responsible for vascularization. Here, we identify an endothelial progenitor/stem-like population located at the inner surface of preexisting blood vessels using the Hoechst method in which stem cell populations are identified as side populations. This population is dormant in the steady state but possesses colony-forming ability, produces large numbers of endothelial cells (ECs) and when transplanted into ischaemic lesions, restores blood flow completely and reconstitutes de-novo long-term surviving blood vessels. Moreover, although surface markers of this population are very similar to conventional ECs, and they reside in the capillary endothelium sub-population, the gene expression profile is completely different. Our results suggest that this heterogeneity of stem-like ECs will lead to the identification of new targets for vascular regeneration therapy. The EMBO Journal (2012) 31, 842-855. doi: 10.1038/emboj.2011.465; Published online 16 December 2011
- リンク情報
- ID情報
-
- DOI : 10.1038/emboj.2011.465
- ISSN : 0261-4189
- PubMed ID : 22179698
- Web of Science ID : WOS:000300872100008