論文

査読有り
2010年12月

[Antimicrobial susceptibility of clinical isolates of aerobic Gram-negative bacteria in 2006].

The Japanese journal of antibiotics
  • Isamu Yoshida
  • Takahiro Yamaguchi
  • Yoshihisa Itoh
  • Mineji Tachibana
  • Choichiro Takahashi
  • Mitsuo Kaku
  • Keiji Kanemitsu
  • Masahiko Okada
  • Yoshinori Horikawa
  • Joji Shiotani
  • Hiroyoshi Kino
  • Yuka Ono
  • Hisashi Baba
  • Shuji Matsuo
  • Seishi Asari
  • Masahiro Toyokawa
  • Kimiko Matsuoka
  • Nobuchika Kusano
  • Motoko Nose
  • Mitsuharu Murase
  • Hitoshi Miyamoto
  • Tetsunori Saikawa
  • Kazufumi Hiramatsu
  • Shigeru Kohno
  • Katsunori Yanagihara
  • Nobuhisa Yamane
  • Isamu Nakasone
  • Hideki Maki
  • Yoshinori Yamano
  • 全て表示

63
6
開始ページ
457
終了ページ
79
記述言語
日本語
掲載種別
研究論文(学術雑誌)

We determined MICs of antibacterial agents against 1280 clinical strains of aerobic Gram-negative bacteria (19 genus or species) isolated at 16 Japanese facilities in 2006. MICs were determined using mostly broth microdilution method and antibacterial activity was assessed. Strains producing extended-spectrum beta-lactamases (ESBL) accounted for 3.7% of Escherichia coli, 2.7% of Klebsiella spp., and 11.4% of Proteus spp. Notably, 18.8% of Proteus mirabilis was found to produce ESBL higher than 16.7% in 2004. This result was higher extremely than other species. Among Haemophilus influenzae, only 1.2% produced beta-lactamase and 62.8% that increased compared with 57.7% in 2004, were beta-lactamase-negative ampicillin-resistant strains when classified by penicillin-binding protein 3 mutation. Although few antibacterial agents against Pseudomonas aeruginosa have potent activity, only three agents--doripenem, ciprofloxacin, and tobramycin-showed an MIC90 of 4 microg/mL. Of all P aeruginosa strains, 5.7% were resistant to six or more agents of nine antipseudomonal agents, a decrease compared to 8.7% in 2004. Against other glucose-non-fermentative Gram-negative bacteria, the activity of most antibacterial agents was similar to that in 2004.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21425597
ID情報
  • ISSN : 0368-2781
  • PubMed ID : 21425597

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