2008年9月
Comparison of time-action profiles of insulin Glargine and NPH insulin in normal and diabetic dogs
Veterinary Research Communications
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 32
- 号
- 7
- 開始ページ
- 563
- 終了ページ
- 573
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s11259-008-9059-5
- 出版者・発行元
- SPRINGER
Intermediate insulin injections are commonly used for glycemic control in insulin dependent diabetic dogs acting as a replacement for natural insulin. Neutral Protamin Hagedorn (NPH) insulin and insulin glargine are two types of injectable insulin preparations commonly used in humans. In our study, we investigated the time-action profiles of both aforementioned insulin preparations in normal dogs in order to determine whether co-administration of NPH and glargine would be of benefit to insulin dependent diabetic dogs as it is for humans suffering from insulin dependent diabetes. Time-action profiles of NPH insulin and insulin glargine in normal dogs demonstrated a clear difference between both insulin preparations confirming that NPH insulin is an intermediate-acting preparation whereas insulin glargine is a long-lasting preparation. In addition, co-administration of NPH insulin and insulin glargine resulted in tight glycemic control as compared to NPH insulin alone in insulin dependent diabetic dogs. However, co-administration result in hypoglycemia at the dosages tested. © Springer Science+Business Media B.V. 2008.
- リンク情報
-
- DOI
- https://doi.org/10.1007/s11259-008-9059-5
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/18575956
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000259276900007&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=52749097176&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=52749097176&origin=inward
- ID情報
-
- DOI : 10.1007/s11259-008-9059-5
- ISSN : 0165-7380
- PubMed ID : 18575956
- SCOPUS ID : 52749097176
- Web of Science ID : WOS:000259276900007