論文

査読有り 国際誌
2019年2月

Osteochondral Autograft Transplantation Technique Augmented by an Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model.

The American journal of sports medicine
  • Ryosuke Hishimura
  • Tomohiro Onodera
  • Kazutoshi Hontani
  • Rikiya Baba
  • Kentaro Homan
  • Shinji Matsubara
  • Zenta Joutoku
  • WooYoung Kim
  • Takayuki Nonoyama
  • Takayuki Kurokawa
  • Jian Ping Gong
  • Norimasa Iwasaki
  • 全て表示

47
2
開始ページ
468
終了ページ
478
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0363546518817527

BACKGROUND: One of the most important limitations of osteochondral autograft transplantation (OAT) is the adverse effect on donor sites in the knee. To decrease the number and/or size of osteochondral defects, we devised a method with biomaterial implantation after OAT. HYPOTHESIS: OAT augmented by ultrapurified alginate (UPAL) gel enhances cartilage repair capacity. STUDY DESIGN: Controlled laboratory study. METHODS: Seventy-five osteochondral defects in rabbits were divided into 3 groups: osteochondral defects with OAT alone, defects with OAT augmented by UPAL gel (combined group), and defects without intervention as controls. Macroscopic and histological evaluations of the reparative tissues were performed at 4 and 12 weeks postoperatively. Histological evaluation of graft cartilage degradation was also performed. To evaluate the effects of UPAL gel on graft healing, repaired bone volumes and osseointegration of the graft were evaluated. Collagen orientation and the mechanical properties of the reparative tissue and graft cartilage were also evaluated qualitatively. RESULTS: The macroscopic and histological evaluations of the combined group were significantly superior to the other groups at 12 weeks postoperatively. Regarding degenerative change of the graft, the histological scores of the combined group were significantly higher than those of the OAT-alone group. The values of repaired subchondral bone volumes and osseointegration of the graft were almost identical in both groups. Collagen orientation and the mechanical properties of the reparative tissue and graft cartilage were significantly better in the combined group than in the other groups. CONCLUSION: Administration of UPAL gel in OAT enhanced cartilage repair and protected graft cartilage without inhibiting subchondral bone repair and graft survival. CLINICAL RELEVANCE: OAT augmented by UPAL gel decreases the number and/or size of osteochondral grafts, minimizing the risk of donor site morbidity. This combination technique has the potential to improve clinical outcomes and expand the surgical indications for OAT.

リンク情報
DOI
https://doi.org/10.1177/0363546518817527
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30624979
ID情報
  • DOI : 10.1177/0363546518817527
  • ISSN : 0363-5465
  • PubMed ID : 30624979

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