Hitomi Tsuiji

Profile Information

Affiliation: Professor, School of Pharmacy, Department of Pharmaceutical Health Care and Science, Aichi Gakuin University

Degree: Ph.D(University of Tokyo)

J-GLOBAL ID: 201201096798723090
researchmap Member ID: B000222176

External link: http://kaken.nii.ac.jp/ja/r/40455358

Research Interests

Research Areas

Education

Apr, 1994 - Mar, 1999

Graduate School of Pharmaceutical Sciences, The University of Tokyo
Apr, 1992 - Mar, 1994

Faculty of Pharmaceutical Sciences, The University of Tokyo
Apr, 1990 - Mar, 1992

東京大学理科II類

Research History

Sep, 2022 - Present

Graduate School of Pharmacy, Studies of Pharmacy, Aichi Gakuin University
Apr, 2022 - Present

Visiting Professor, Graduate School of Pharmaceutical Sciences, Nagoya City University
Apr, 2022 - Present

Professor, School of Pharmacy, Department of Pharmaceutical Health Care and Science, Aichi Gakuin University
Apr, 2014 - Mar, 2022

Graduate School of Pharmaceutical Sciences, Nagoya City University
2014 - 2015

Nagoya University
2009 - 2014

博士研究員, 理化学研究所脳科学総合研究センター
2006 - 2009

博士研究員, 基幹研究所, 理化学研究所
2003 - 2006

Researcher, University of Virginia School of Medicine
1999 - 2002

博士研究員, 国立がんセンター研究所

Committee Memberships

Apr, 2023 - Present

Councilor, Japan Neuroscience Society
Apr, 2023 - Present

代議員, 日本薬学会
Apr, 2018 - Mar, 2022

会計幹事, 日本RNA学会

Papers

dCas13-mediated translational repression for accurate gene silencing in mammalian cells.

Antonios Apostolopoulos, Naohiro Kawamoto, Siu Yu A Chow, Hitomi Tsuiji, Yoshiho Ikeuchi, Yuichi Shichino, Shintaro Iwasaki

Nature communications, 15(1) 2205-2205, Mar 11, 2024
The Plasma Membrane Polarity Is Higher in the Neuronal Growth Cone than in the Cell Body of Hippocampal and Cerebellar Granule Neurons.

Shintaro Oya, Katsunari Korogi, Takao Kohno, Hitomi Tsuiji, Dmytro I Danylchuk, Andrey S Klymchenko, Yosuke Niko, Mitsuharu Hattori

Biological & pharmaceutical bulletin, 46(12) 1820-1825, 2023
C9ORF72 dipeptide repeat proteins disrupt formation of GEM bodies and induce aberrant accumulation of survival of motor neuron protein

Yuma Kato, Minnie Naganuma, Ikuma Nakagawa, Kazunari Onodera, Hideyuki Okano, Haruhisa Inoue, Mitsuharu Hattori, Yohei Okada, Hitomi Tsuiji

bioRxiv, Mar 25, 2021 Last authorCorresponding author
Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation

Hiroto Inagaki, Nao Hosoda, Hitomi Tsuiji, Shin-ichi Hoshino

Journal of Biological Chemistry, 295(47) 15810-15825, Nov, 2020 Peer-reviewed
Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice.

Eisuke Okugawa, Himari Ogino, Tomofumi Shigenobu, Yuko Yamakage, Hitomi Tsuiji, Hisashi Oishi, Takao Kohno, Mitsuharu Hattori

Scientific reports, 10(1) 4471-4471, Mar 11, 2020 Peer-reviewed
A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.

Yamakage Y, Kato M, Hongo A, Ogino H, Ishii K, Ishizuka T, Kamei T, Tsuiji H, Miyamoto T, Oishi H …

Molecular and cellular neurosciences, 100 103401-103401, Sep, 2019 Peer-reviewed
Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway.

Kohei Nishino, Seiji Watanabe, Jin Shijie, Yuri Murata, Kotaro Oiwa, Okiru Komine, Fumito Endo, Hitomi Tsuiji, Manabu Abe, Kenji Sakimura …

Acta neuropathologica communications, 7(1) 118-118, Jul 25, 2019 Peer-reviewed
Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse.

Yamakage Y, Tsuiji H, Kohno T, Ogino H, Saito T, Saido TC, Hattori M

Biological & pharmaceutical bulletin, 42(3) 354-356, 2019 Peer-reviewed
Reelin deficiency leads to aberrant lipid composition in mouse brain.

Tomoharu Mizukami, Kazutaka Ikeda, Yuta Shimanaka, Katsunari Korogi, Chunyu Zhou, Hiroshi Takase, Hitomi Tsuiji, Nozomu Kono, Takao Kohno, Hiroyuki Arai …

Biochemical and biophysical research communications, 505(1) 81-86, Oct 20, 2018 Peer-reviewed
TDP-43 accelerates age-dependent degeneration of interneurons

Hitomi Tsuiji, Ikuyo Inoue, Mari Takeuchi, Asako Furuya, Yuko Yamakage, Seiji Watanabe, Masato Koike, Mitsuharu Hattori, Koji Yamanaka

SCIENTIFIC REPORTS, 7(1) 14972, Nov, 2017 Peer-reviewedLead authorCorresponding author
Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin

Himari Ogino, Arisa Hisanaga, Takao Kohno, Yuta Kondo, Kyoko Okumura, Takana Kamei, Tempei Sato, Hiroshi Asahara, Hitomi Tsuiji, Masaki Fukata …

JOURNAL OF NEUROSCIENCE, 37(12) 3181-3191, Mar, 2017 Peer-reviewed
There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS

Aaron D. Gitler, Hitomi Tsuiji

BRAIN RESEARCH, 1647 19-29, Sep, 2016 Peer-reviewedLast authorCorresponding author
Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells.

Naoki Ichiyanagi, Koki Fujimori, Masato Yano, Chikako Ishihara-Fujisaki, Takefumi Sone, Tetsuya Akiyama, Yohei Okada, Wado Akamatsu, Takuya Matsumoto, Mitsuru Ishikawa …

Stem cell reports, 6(4) 496-510, Apr 12, 2016 Peer-reviewed
Spliceosome integrity is defective in the motor neuron diseases ALS and SMA

Hitomi Tsuiji, Yohei Iguchi, Asako Furuya, Ayane Kataoka, Hiroyuki Hatsuta, Naoki Atsuta, Fumiaki Tanaka, Yoshio Hashizume, Hiroyasu Akatsu, Shigeo Murayama …

EMBO MOLECULAR MEDICINE, 5(2) 221-234, Feb, 2013 Peer-reviewedLead authorCorresponding author
Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1

Hitomi Tsuiji, Rei Yoshimoto, Yuko Hasegawa, Masaaki Furuno, Minoru Yoshida, Shinichi Nakagawa

GENES TO CELLS, 16(5) 479-490, May, 2011 Peer-reviewedLead author
Cadherin conformations associated with dimerization and adhesion

Hitomi Tsuiji, Liang Xu, Kathleen Schwartz, Barry M. Gumbiner

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(17) 12871-12882, Apr, 2007 Peer-reviewedLead author
Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion

H Tsuiji, S Takasaki, M Sakamoto, T Irimura, S Hirohashi

GLYCOBIOLOGY, 13(7) 521-527, Jul, 2003 Peer-reviewedLead author
Overexpression of orphan G-Protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations

Y Yamamoto, M Sakamoto, G Fujii, H Tsuiji, K Kanetaka, M Asaka, S Hirohashi

HEPATOLOGY, 37(3) 528-533, Mar, 2003 Peer-reviewed
Malignant and other properties of human colon carcinoma cells after suppression of sulfomucin production in vitro

H Tsuiji, S Nakatsugawa, T Ishigaki, T Irimura

CLINICAL & EXPERIMENTAL METASTASIS, 17(2) 97-104, Mar, 1999 Peer-reviewedLead author
Expression of mucin-associated sulfo-Le(a) carbohydrate epitopes on human colon carcinoma cells

H Tsuiji, M Hayashi, DM Wynn, T Irimura

JAPANESE JOURNAL OF CANCER RESEARCH, 89(12) 1267-1275, Dec, 1998 Peer-reviewedLead author

Misc.

Animal Models for Neurodegenerative Disorders

Hitomi Tsuiji, Koji Yamanaka

Animal Biotechnology: Models in Discovery and Translation, 39-56, Dec, 2013
病態に根ざしたALSの新規治療法開発 TDP-43の機能変調による運動神経変性機序の解明

山中宏二, 築地仁美, 渡辺祥司, 金子貢巳, 古屋亜佐子, 井口洋平, 熱田直樹, 田中章景, 祖父江元, 初田裕幸 …

神経変性疾患に関する調査研究班分科班「病態に根ざしたALSの新規治療法開発」平成24年度研究報告書, 2013
Regulation of spliceosome by ALS-causative gene TDP-43

Hitomi Tsuiji, Ayane Kataoka, Koji Yamanaka

NEUROSCIENCE RESEARCH, 71 E102-E102, 2011
核内長鎖ノンコーディングRNA Gomafuは動物の行動を制御する

曽根正光, 築地仁美, 芳本玲, 吉田稔, 北市清幸, 山本経之, 阿部高也, 高雄啓三, 宮川剛, 中川真一

日本RNA学会年会要旨集, 12th 70, Jul 27, 2010
mRNA型ノンコーディングRNAであるGomafuの生化学的性質の検討

築地仁美, 曽根正光, 中川真一

日本RNA学会年会要旨集, 9th 234, Jul 28, 2007
Aberrant O-glycosylation inhibits stable expression of dysadherin, a cancer-associated antigen, and facilitates cell-cell adhesion in carcinoma cells

H Tsuiji, S Takasaki, M Sakamoto, T Irimura, S Hirohashi

GLYCOBIOLOGY, 12(10) 666-666, Oct, 2002
ヒト大腸硫酸化ムチンを免疫原に作製されたモノクローナル抗体91.9Hによる硫酸化ルイスA抗原の認識

築地仁美, 池原譲, 成松久, 入村達郎

日本癌学会総会記事, 57回 183-183, Aug, 1998
Loss of sulfomucin in advanced colon carcinomas: Structural basis and possible biological relevance

H Tsuiji, S Iida, S Nakatsugawa, T Ishigaki, T Irimura

GLYCOBIOLOGY, 7(7) 126-126, Oct, 1997 Peer-reviewed

Research Projects

RNA結合タンパク質量の増減による、筋萎縮性側索硬化症ALSの治療法開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2024

築地仁美
Elucidation of pathophysiological implications of interneuron degeneration in frontotemporal dementia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Tsuiji Hitomi
Common defects of RNA metabolism in motor neuron diseases SMA and ALS

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Tsuiji Hitomi, YAMANAKA Koji
Defective RNA metabolism in motor neurons from Amyotrophic Lateral Scelosis patients

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

TSUIJI Hitomi
Functional analysis of Gomafu, the mRNA-like non-coding RNA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (Start-up), Japan Society for the Promotion of Science, 2007 - 2008

TSUIJI Hitomi

Other

Editorial Board: Frontiers in RNA Research

Aug, 2023 - Present
Editorial Board: Frontiers in Molecular Neuroscience

May, 2020 - Present
Editorial Board: Scientific Reports

2018 - Present

Profile Information

Research Interests

Research Areas

Education

Research History

Committee Memberships

Papers

Misc.

Research Projects

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