2015年12月
RASSF6; the Putative Tumor Suppressor of the RASSF Family
CANCERS
- ,
- ,
- 巻
- 7
- 号
- 4
- 開始ページ
- 2415
- 終了ページ
- 2426
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/cancers7040899
- 出版者・発行元
- MDPI AG
Humans have 10 genes that belong to the Ras association (RA) domain family (RASSF). Among them, RASSF7 to RASSF10 have the RA domain in the N-terminal region and are called the N-RASSF proteins. In contradistinction to them, RASSF1 to RASSF6 are referred to as the C-RASSF proteins. The C-RASSF proteins have the RA domain in the middle region and the Salvador/RASSF/Hippo domain in the C-terminal region. RASSF6 additionally harbors the PSD-95/Discs large/ZO-1 (PDZ)-binding motif. Expression of RASSF6 is epigenetically suppressed in human cancers and is generally regarded as a tumor suppressor. RASSF6 induces caspase-dependent and -independent apoptosis. RASSF6 interacts with mammalian Ste20-like kinases (homologs of Drosophila Hippo) and cross-talks with the Hippo pathway. RASSF6 binds MDM2 and regulates p53 expression. The interactions with Ras and Modulator of apoptosis 1 (MOAP1) are also suggested by heterologous protein-protein interaction experiments. RASSF6 regulates apoptosis and cell cycle through these protein-protein interactions, and is implicated in the NF-kB and JNK signaling pathways. We summarize our current knowledge about RASSF6 and discuss what common and different properties RASSF6 and the other C-RASSF proteins have.
- リンク情報
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- DOI
- https://doi.org/10.3390/cancers7040899
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26690221
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695899
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000209952900031&DestApp=WOS_CPL
- ID情報
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- DOI : 10.3390/cancers7040899
- ISSN : 2072-6694
- PubMed ID : 26690221
- PubMed Central 記事ID : PMC4695899
- Web of Science ID : WOS:000209952900031