2017年12月
BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression
GENES TO CELLS
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- 巻
- 22
- 号
- 12
- 開始ページ
- 993
- 終了ページ
- 1003
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/gtc.12540
- 出版者・発行元
- WILEY
RASSF6, a member of the tumor suppressor Ras-association domain family proteins, induces apoptosis in the caspase-dependent and caspase-independent manners. RASSF6 interacts with MDM2 and stabilizes p53. BCL-XL is a prosurvival member of BCL-2 family proteins. BCL-XL directly inhibits proapoptotic BAX and BAK. BCL-XL also traps tBID, a proapoptotic activator BH3-only protein, and sequesters p53. In addition, BCL-XL regulates the mitochondrial membrane permeability via voltage-dependent anion channel. In these manners, BCL-XL plays an antiapoptotic role. We report the interaction of BCL-XL with RASSF6. BCL-XL inhibits the interaction between RASSF6 and MDM2 and suppresses p53 expression. Consequently, BCL-XL antagonizes RASSF6-mediated apoptosis. Thus, the inhibition of RASSF6-mediated apoptosis also underlies the prosurvival role of BCL-XL.
- リンク情報
- ID情報
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- DOI : 10.1111/gtc.12540
- ISSN : 1356-9597
- eISSN : 1365-2443
- PubMed ID : 29193479
- Web of Science ID : WOS:000417527700002