論文

査読有り 国際誌
2020年2月

CD133 and epithelial cell adhesion molecule expressions in the cholangiocarcinoma component are prognostic factors for combined hepatocellular cholangiocarcinoma.

Hepatology research : the official journal of the Japan Society of Hepatology
  • Kazuki Wakizaka
  • ,
  • Hideki Yokoo
  • ,
  • Toshiya Kamiyama
  • ,
  • Tatsuhiko Kakisaka
  • ,
  • Masafumi Ohira
  • ,
  • Michio Tani
  • ,
  • Koichi Kato
  • ,
  • Yuki Fujii
  • ,
  • Ko Sugiyama
  • ,
  • Akihisa Nagatsu
  • ,
  • Shingo Shimada
  • ,
  • Tatsuya Orimo
  • ,
  • Hirofumi Kamachi
  • ,
  • Ryosuke Matsuoka
  • ,
  • Akinobu Taketomi

50
2
開始ページ
258
終了ページ
267
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/hepr.13443

AIM: A new classification of combined hepatocellular cholangiocarcinoma (CHC) was recently reported. Cancer stem cells have been associated with CHC carcinogenesis. This study examined the association of cancer stem cell marker expression and prognosis in CHC classified using the new classification. METHODS: We enrolled 26 CHC patients and classified them according to the new classification. We evaluated the expression of cancer stem cell markers (CD56, CD133, and epithelial cell adhesion molecule [EpCAM]) by immunohistochemical staining in each component. We analyzed the association between expressions and prognosis. RESULTS: Seven cases were hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) (cHCC-CCA), 12 were HCC and intermediate cell carcinoma (HCC-INT), and seven were intermediate cell carcinoma (INT). The CD133-positive rate tended to be higher in the CCA (42.9%) and INT component (50.0%) than the HCC component (14.3%) in cHCC-CCA. In HCC-INT, the CD133-positive rate in the INT component (83.3%) was significantly higher than the HCC component (8.3%; P = 0.001). For EpCAM, the positive rate in the CCA component (71.4%) and INT component (50.0%) tended to be higher than the HCC component (14.3%) in cHCC-CCA. Overall survival and disease-free survival were significantly worse in cases with CD133-positive (P = 0.048 and P = 0.048, respectively) or EpCAM-positive (P = 0.041 and P = 0.041, respectively) CCA component in cHCC-CCA. CONCLUSIONS: INT and CCA components showed higher expression rates of cancer stem cell markers than the HCC component. CD133 or EpCAM expression in the CCA component was associated with poor prognosis in cHCC-CCA.

リンク情報
DOI
https://doi.org/10.1111/hepr.13443
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31661725

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