Takumi Hiyoshi

Profile Information

Affiliation: Graduate School of Medical and Dental Sciences Research Center for Advanced Oral Science, Niigata University

Degree: 博士（歯学）(Mar, 2021, 新潟大学)

Researcher number: 80911437
J-GLOBAL ID: 201901003876489494
researchmap Member ID: B000361597

Research Areas

Life sciences / Conservative dentistry and endodontics /

Research History

Mar, 2023 - Present

博士研究員, 米国ハーバード大学ジョンA.ポールソン工学応用科学部
Apr, 2022 - Present

助教, 高度口腔機能教育研究センター, 新潟大学大学院医歯学総合研究科
Apr, 2021 - Mar, 2022

特任助教, 高度口腔機能教育研究センター, 新潟大学大学院医歯学総合研究科

Education

Apr, 2017 - Mar, 2021

Graduate School of Medical and Dental Sciences, Niigata University
Apr, 2010 - Mar, 2016

School of Dentistry, Faculty of Dentistry, Niigata University

Papers

C-terminal lysine residue of pneumococcal triosephosphate isomerase contributes to its binding to host plasminogen

Satoru Hirayama, Takumi Hiyoshi, Yoshihito Yasui, Hisanori Domon, Yutaka Terao

Microorganisms, 11(5) 1198, May, 2023 Peer-reviewed
Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia

Toshihito Isono, Satoru Hirayama, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Takumi Hiyoshi, Kridtapat Sirisereephap, Shoji Takenaka, Yuichiro Noiri, Yutaka Terao

Journal of Biological Chemistry, 104760-104760, Apr, 2023 Peer-reviewed
Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment.

Takizawa F, Domon H, Hiyoshi T, Tamura H, Shimizu K, Maekawa T, Tabeta K, Ushida A, Terao Y

PLOS ONE, 18(4) e0284115, Apr, 2023 Peer-reviewed
Erythromycin Restores Osteoblast Differentiation and Osteogenesis Suppressed by Porphyromonas gingivalis Lipopolysaccharide

Hikaru Tamura, Tomoki Maekawa, Hisanori Domon, Kridtapat Sirisereephap, Toshihito Isono, Satoru Hirayama, Takumi Hiyoshi, Karin Sasagawa, Fumio Takizawa, Takeyasu Maeda, Yutaka Terao, Koichi Tabeta

Pharmaceuticals, 16(2) 303-303, Feb 15, 2023 Peer-reviewed
Soybean peptide inhibits the biofilm of periodontopathic bacteria via bactericidal activity

105497-105497, Jul, 2022 Peer-reviewed
Osteoimmunology in periodontitis: Local proteins and compounds to alleviate periodontitis

Sirisereephap K, Maekawa T, Tamura H, Hiyoshi T, Domon H, Isono T, Terao Y, Maeda T, Tabeta K

International Journal of Molecular Sciences, 23(10) 5540, May, 2022 Peer-reviewed
Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules

Hiyoshi, T, Domon, H, Maekawa, T, Tamura, H, Isono, T, Hirayama, S, Sasagawa, K, Takizawa, F, Tabeta, K, Terao, Y

Scientific Reports, 12 8159, May, 2022 Peer-reviewedLead author
Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation.

Hirayama S, Domon H, Hiyoshi T, Isono T, Tamura H, Sasagawa K, Takizawa F, Terao Y

FEBS Open Bio, 12(6) 1206-1219, Mar, 2022 Peer-reviewed
Matcha green tea exhibits bactericidal activity against Streptococcus pneumoniae and inhibits functional pneumolysin.

Sasagawa K, Domon H, Sakagami R, Hirayama S, Maekawa T, Isono T, Hiyoshi T, Tamura H, Takizawa F, Fukushima Y, Tabeta K, Terao Y

Antibiotics, 10(12) 1550, Dec, 2021
Clarithromycin inhibits pneumolysin production via downregulation of ply gene transcription despite autolysis activation.

Domon H, Isono T, Hiyoshi T, Tamura H, Sasagawa K, Maekawa T, Hirayama S, Yanagihara K, Terao Y

Microbiology Spectrum, 9(2) e00318-21, Sep, 2021 Peer-reviewed
Effects of Erythromycin on Osteoclasts and Bone Resorption via DEL-1 Induction in Mice

Hikaru Tamura, Tomoki Maekawa, Hisanori Domon, Takumi Hiyoshi, Satoru Hirayama, Toshihito Isono, Karin Sasagawa, Daisuke Yonezawa, Naoki Takahashi, Masataka Oda, Takeyasu Maeda, Koichi Tabeta, Yutaka Terao

ANTIBIOTICS-BASEL, 10(312), Mar, 2021 Peer-reviewed
Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability.

Taisuke Hasegawa, Shoji Takenaka, Masataka Oda, Hisanori Domon, Takumi Hiyoshi, Karin Sasagawa, Tatsuya Ohsumi, Naoki Hayashi, Yasuko Okamoto, Hirofumi Yamamoto, Hayato Ohshima, Yutaka Terao, Yuichiro Noiri

BMC microbiology, 20(1) 361-361, Nov, 2020 Peer-reviewed
Treatment of severe pneumonia by hinokitiol in a murine antimicrobial-resistant pneumococcal pneumonia model.

Toshihito Isono, Hisanori Domon, Kosuke Nagai, Tomoki Maekawa, Hikaru Tamura, Takumi Hiyoshi, Katsunori Yanagihara, Eiji Kunitomo, Shoji Takenaka, Yuichiro Noiri, Yutaka Terao

PloS one, 15(10) e0240329, Oct, 2020 Peer-reviewed
Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1.

Tomoki Maekawa, Hikaru Tamura, Hisanori Domon, Takumi Hiyoshi, Toshihito Isono, Daisuke Yonezawa, Naoki Hayashi, Naoki Takahashi, Koichi Tabeta, Takeyasu Maeda, Masataka Oda, Athanasios Ziogas, Vasileia Ι Alexaki, Triantafyllos Chavakis, Yutaka Terao, George Hajishengallis

JCI Insight 5(15) e136706, 5(15), Aug, 2020 Peer-reviewed
Animal model of periodontitis — Analysis of experimental ligature-induced periodontitis model in mice

Tamura H, Maekawa T, Hiyoshi T, Terao Y

Methods in Molecular Biology (published by Springer Nature), Aug, 2020 Peer-reviewedInvited
Protective effect of hinokitiol against periodontal bone loss in ligature-induced experimental periodontitis in mice.

Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Daisuke Yonezawa, Eiji Kunitomo, Koichi Tabeta, Yutaka Terao

Archives of oral biology, 112 104679-104679, Feb 7, 2020 Peer-reviewedLead author
Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria predominant in the oral cavity and upper airways.

Domon H, Hiyoshi T, Maekawa T, Yonezawa D, Tamura H, Kawabata S, Yanagihara K, Kimura O, Kunitomo E, Terao Y

Microbiology and immunology, May, 2019 Peer-reviewed
Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis.

Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Kosuke Nagai, Hikaru Tamura, Naoki Takahashi, Daisuke Yonezawa, Tomohiro Miyoshi, Akihiro Yoshida, Koichi Tabeta, Yutaka Terao

Microbiology and immunology, 63(3-4) 100-110, Mar, 2019 Peer-reviewedLead author
Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis.

Hikaru Tamura, Tomoki Maekawa, Hisanori Domon, Takumi Hiyoshi, Daisuke Yonezawa, Kosuke Nagai, Akihito Ochiai, Masayuki Taniguchi, Koichi Tabeta, Takeyasu Maeda, Yutaka Terao

Archives of oral biology, 98 132-139, Feb, 2019 Peer-reviewed
Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.

Kosuke Nagai, Hisanori Domon, Tomoki Maekawa, Takumi Hiyoshi, Hikaru Tamura, Daisuke Yonezawa, Rie Habuka, Akihiko Saitoh, Yutaka Terao

Vaccine, 37(1) 160-168, Jan 3, 2019 Peer-reviewed

Research Projects

プロテオーム解析法を用いたエラスターゼによる歯周炎重症化メカニズムの網羅的解析

若手研究, 日本学術振興会, Apr, 2022 - Mar, 2024
イオン液体を用いた経口腔粘膜局所薬物投与法の開発

令和４年度国際共同研究加速グラント, Dec, 2022 - Mar, 2023
エラスターゼを標的とした歯周炎重症化機序の探索とその分子メカニズムの解明

研究活動スタート支援, 日本学術振興会, Oct, 2021 - Mar, 2023

代表, 日吉巧
オゾンナノ水を用いた医療と食の安全研究

新潟大学U-goグラント, Sep, 2021 - Mar, 2022

代表, 日吉巧

Awards

Presentations

好中球エラスターゼによる歯周炎重症化機序と新規治療法の探索

日吉巧

第4回オーラルサイエンス研究会, Nov 13, 2022
エラスターゼの歯肉上皮バリア傷害作用を介した歯周組織破壊機序の解析

日吉巧, 土門久哲, 前川知樹, 田村光, 笹川花梨, 多部田康一

日本歯科保存学会 2021 年度秋季学術大会（第 155 回）, Oct 28, 2021
好中球エラスターゼの歯肉上皮バリア傷害作用による歯周炎重症化メカニズム解析

日吉巧

第64回秋季歯周病学会学術大会 SUNSTAR Young Investigator Award 口演（受賞）, Oct 15, 2021
好中球エラスターゼに着目した歯周炎重症化メカニズム解析と新規治療法の探索

日吉巧

一般財団法人岩垂育英会令和2年度奨学生研究成果発表会, Mar 13, 2021
好中球エラスターゼによる歯周炎重症化メカニズム解析と新規治療法への応用

日吉巧, 土門久哲, 前川知樹, 田村光, 米澤大輔, 多部田, 康一寺尾豊

新潟歯学会, Nov 7, 2020
Analysis of the mechanism for periodontitis progression induced by neutrophil elastase

Oct 16, 2020
Inhibitory effect of hinokitiol on periodontal bone loss in ligature-induced experimental periodontitis in mice

Jul 13, 2020
Aggregatibacter actinomycetemcomitans Leukotoxin Induce Periodontal Tissue Destruction Via Neutrophil Elastase

Takumi Hiyoshi, Hisanori Domon, Tomoki Maekawa, Hikaru Tamura, Daisuke Yonezawa, Yutaka Terao, Koichi Tabeta

The 98th General Session of the International Association for Dental Research (IADR) – Washington, D.C. USA, Mar 20, 2020
Analysis of the mechanism underlying accelerated periodontal disease associated with Aggregatibacter actinomycetemcomitans

Takumi Hiyoshi

May 24, 2019
Analysis of periodontal tissue destruction induced by A. actinomycetemcomitans leukotoxin

日吉巧

第92回日本細菌学会総会, Apr 23, 2019
Aggregatibacter actinomycetemcomitans が産生するロイコトキシンによる歯周組織破壊メカニズムの解析

日吉巧

第6回五大学・口腔微生物研究会, Sep 8, 2018
Analysis of Aggregativacter actinomycetemcomitans-induced tissue destruction in periodontitis

Jun 1, 2018
Aggregatibacter actinomycetemcomitansが産生するleukotoxinの宿主細胞に対する作用解析

日吉巧

第5回五大学・口腔微生物研究会, Sep 19, 2017

Media Coverage

新聞・Web報道：「歯周病重症化のメカニズム解明－新潟大」

日本歯科新聞, May 24, 2022
オンライン報道「植物由来成分に歯周病の予防効果、新潟大学と小林製薬が発見」日吉巧

大学ジャーナルオンライン, Feb 19, 2020
新聞報道「新潟大学院生らと小林製薬の研究グループが、植物由来成分による歯周病予防効果を発見」日吉巧

にいがた経済新聞, Feb 17, 2020

Misc.

米由来ペプチドによる炎症制御機構の検索と歯周病治療への応用研究

田村光, 前川知樹, 土門久哲, 日吉巧, 米澤大輔, 前田健康, 多部田康一, 寺尾豊

新潟歯学会雑誌, 49(2) 82-82, Dec, 2019
エリスロマイシンのDel-1再誘導による炎症性骨吸収抑制効果の検証

田村光, 前川知樹, 土門久哲, 日吉巧, 米澤大輔, 永井康介, 前田健康, 寺尾豊, 多部田康一

日本歯周病学会会誌, 61(春季特別) 126-126, May, 2019
肺炎球菌性肺炎の病態発症メカニズムの解析と新規肺炎予防法への展開

永井康介, 土門久哲, 前川知樹, 日吉巧, 田村光, 米澤大輔, 荒井良明, 横地麻衣, 多部田康一, 寺尾豊

新潟歯学会雑誌, 48(1) 57-58, Jun, 2018
食物由来ペプチドを用いた炎症と骨吸収の制御法の検索

田村光, 前川知樹, 米澤大輔, 土門久哲, 永井康介, 日吉巧, 多部田康一, 前田健康, 寺尾豊, 吉江弘正

日本歯周病学会会誌, 60(春季特別) 125-125, May, 2018
Aggregatibacter actinomycetemcomitansによる歯周組織破壊メカニズムの解析

日吉巧, 土門久哲, 永井康介, 前川知樹, 高橋直紀, 米澤大輔, 田村光, 吉田明弘, 寺尾豊, 吉江弘正

日本歯周病学会会誌, 60(春季特別) 128-128, May, 2018
食物由来ペプチドを用いた炎症と骨吸収の制御法の検索

田村光, 田村光, 田村光, 前川知樹, 前川知樹, 米澤大輔, 土門久哲, 土門久哲, 永井康介, 日吉巧, 日吉巧, 多部田康一, 多部田康一, 前田健康, 寺尾豊, 寺尾豊, 吉江弘正

日本歯周病学会会誌(Web), 60 125, May 1, 2018
令和元年度新潟大学国際会議研究発表支援事業採択

日吉巧
令和元年度新潟大学論文投稿支援事業採択

日吉巧

Professional Memberships

Sep, 2018 - Present

JAPANESE SOCIETY FOR BACTERIOLOGY
Jun, 2017 - Present

THE JAPANESE SOCIETY OF CONSERVATIVE DENTISTRY
Oct, 2016 - Present

JAPANESE SOCIETY OF PERIODONTOLOGY
JAPANESE ASSOCIATION FOR ORAL BIOLOGY

Profile Information

Research Areas

Research History

Education

Papers

Research Projects

Awards

Presentations

Media Coverage

Misc.

Professional Memberships

Menu

Coauthors