1999年9月
Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
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- 巻
- 277
- 号
- 3
- 開始ページ
- C403
- 終了ページ
- C411
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- AMER PHYSIOLOGICAL SOC
Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway. Am. J. Physiol. 277 (Cell Physiol. 46): C403-C411, 1999.-The cell adhesion molecule intercellular adhesion molecule-1 (ICAM-1) plays a pivotal role in inflammatory responses. Quercetin (3,3',4',5,7-pentahydroxyflavone), a naturally occurring dietary flavonol, has potent anti-inflammatory properties. The effect of quercetin on ICAM-1 expression induced by agonists phorbol 12-myristate 13-acetate (PMA) and tumor necrosis factor-alpha (TNF-alpha) in human endothelial cell line ECV304 (ECV) was investigated. Quercetin treatment downregulated both PMA- and TNF-alpha-induced surface expression, as well as the ICAM-1 mRNA levels, in ECV cells in a dose-dependent (10-50 l-IM) manner. Quercetin had no effect on PMA- or TNF-alpha-induced nuclear factor-KB (NF-KB) activation. However, under similar conditions a remarkable dose-dependent downregulation of activator protein-1 (AP-1) activation was observed. This decrease in AP-1 activation was observed to be associated with the inhibitory effects of quercetin on the c-Jun NH2-terminal kinase (JNK) pathway. These results suggest that quercetin downregulates both PMA- and TNF-alpha-induced ICAM-1 expression via inhibiting both AP-1 activation and the JNK pathway.
- リンク情報
- ID情報
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- ISSN : 0363-6143
- Web of Science ID : WOS:000082388800007