A computational model of global strontium cycle in the late Cenozoic (Neogene) has been built up. It is used for evaluating the influence of the weathering in the HTP (Himalayan and Tibetan Plateau) region due to the uplift and denudation and that in high-latitude area due to the glaciation on the increase in seawater <SUP>87</SUP>Sr/<SUP>86</SUP>Srr in the late Cenozoic. The results indicate that (1) approximately 30% of the increase in <SUP>87</SUP>Sr/<SUP>86</SUP>Srr of seawater can be explained by the HTP weathering, which is substantially influential as compared to its small area;(2) however, the <SUP>87</SUP>Sr/<SUP>86</SUP>Srr fluctuations of silicate weathering in the region except the HTP region could be partially attributed to the weathering in high latitude especially the Antarctica;(3) the correlation between this <SUP>87</SUP>Sr/<SUP>86</SUP>Srr variation and δ<SUP>18</SUP>O variation is identified in from the late Oligocene to the early Miocene and the Pliocene to the present, whereas the correlation is not confirmed in from the middle to late Miocene.<BR>This discrepancy may be partially derived from uncertainty of estimation of the HTP uplift and the <SUP>87</SUP>Sr/<SUP>86</SUP>Srr variation in the region except the HTP and high-latitude areas. The critical problems in attributing the increase in seawater <SUP>87</SUP>Sr/<SUP>86</SUP>Srr to the weathering in high-latitude area might be low temperature and water availability. The former could be overcome by the previous studies of dependence of weathering rate and temperature, but the water availability in high latitude might have varied with time. Because low water availability has been presumed since late Miocene by previous studies, the above disagreement in from the middle to the late Miocene might be identified.