MANYA Hiroshi Last updated: Oct 5, 2018 at 10:07
Academic & Professional Experience
Apr 2013
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Today
Leader, Molecular Glycobiology, Research team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Awards & Honors
2018
Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production, JB Award
Winner: Akasaka-Manya K., Manya H., et al.
2011
Role of N-glycans in maintaining the activity of protein O-mannosyltransferases POMT1 and POMT2, JB Award
Winner: Manya H., et al
2010
Incentive award of The Japanese Society for Carbohydrate Research
Published Papers
Imae R, Manya H, Tsumoto H, Osumi K, Tanaka T, Mizuno M, Kanagawa M, Kobayashi K, Toda T, Endo T
The Journal of biological chemistry 293(31) 12186-12198 Aug 2018 [Refereed]
Nishihara R, Kobayashi K, Imae R, Tsumoto H, Manya H, Mizuno M, Kanagawa M, Endo T, Toda T
Biochemical and biophysical research communications 497(4) 1025-1030 Mar 2018 [Refereed]
Manya H, Endo T
Biochimica et biophysica acta Jul 2017 [Refereed]
Nagae M, Mishra SK, Neyazaki M, Oi R, Ikeda A, Matsugaki N, Akashi S, Manya H, Mizuno M, Yagi H, Kato K, Senda T, Endo T, Nogi T, Yamaguchi Y
Genes to cells : devoted to molecular & cellular mechanisms 22(4) 348-359 Apr 2017 [Refereed]
Akasaka-Manya K, Kawamura M, Tsumoto H, Saito Y, Tachida Y, Kitazume S, Hatsuta H, Miura Y, Hisanaga SI, Murayama S, Hashimoto Y, Manya H*, Endo T
Journal of biochemistry 161(1) 99-111 Jan 2017 [Refereed]
Manya H, Yamaguchi Y, Kanagawa M, Kobayashi K, Tajiri M, Akasaka-Manya K, Kawakami H, Mizuno M, Wada Y, Toda T, Endo T
The Journal of biological chemistry 291(47) 24618-24627 Nov 2016 [Refereed]
Yang H, Manya H, Kobayashi K, Jiao H, Fu X, Xiao J, Li X, Wang J, Jiang Y, Toda T, Endo T, Wu X, Xiong H
Journal of human genetics 61(8) 753-759 Aug 2016 [Refereed]
Kuwabara N, Manya H, Yamada T, Tateno H, Kanagawa M, Kobayashi K, Akasaka-Manya K, Hirose Y, Mizuno M, Ikeguchi M, Toda T, Hirabayashi J, Senda T, Endo T, Kato R
Proceedings of the National Academy of Sciences of the United States of America 113(33) 9280-9285 Aug 2016 [Refereed]
Xu M, Yamada T, Sun Z, Eblimit A, Lopez I, Wang F, Manya H, Xu S, Zhao L, Li Y, Kimchi A, Sharon D, Sui R, Endo T, Koenekoop RK, Chen R
Human molecular genetics 25(8) 1479-1488 Apr 2016 [Refereed]
Kanagawa M*, Kobayashi K*, Tajiri M*, Manya H*, Kuga A*, Yamaguchi Y, Akasaka-Manya K, Furukawa J, Mizuno M, Kawakami H, Shinohara Y, Wada Y, Endo T, Toda T (*co-first author)
Cell reports 14(9) 2209-2223 Mar 2016 [Refereed]
Misc
Kanagawa M, Manya H
Glycobiology 27(7) 599-600 Jul 2017 [Refereed]
Methods. Enzymol. 479 343-352 2010
Geriatr. Gerontol. Int. 10(Supplement 1) S80-S87 2010
[Biosynthesis of O-mannosyl glycan in mammals].
Manya H, Endo T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 53 1429-1433 Sep 2008 [Refereed][Invited]
O-Mannosyltransferase and POMGnT1.
Experimental Glycoscience Glycobiology 30-32 2008
Books etc
Vitam Horm.
Akasaka-Manya K, Manya H, Endo T (Part:Contributor, Function and Change with Aging of α-Klotho in the Kidney.)
Elsevier Mar 2016
Sugar chains
Manya H, Endo T. (Part:Contributor, O-Mannosyl glycan and muscular dystrophy)
Springer 2015
Handbook of Glycosyl transferases and related genes
Manya H, Endo T. (Part:Contributor, Protein O-linked-mannose β-1,2-N-acetyl glucosaminyltransferase 1 (POMGNT1), Protein O-mannosyl-transferase 1,2 (POMT1,2))
Springer 2014
Research Grants & Projects
The biosynthetic mechanism of O-mannosyl glycan diversity
Project Year: 2016 Investigator(s): MANYA Hiroshi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2006 - 2008 Investigator(s): Hiroshi MANYA
The role of complex carbohydrate in vivo
