MANYA Hiroshi

J-GLOBAL         Last updated: Oct 16, 2019 at 22:08
MANYA Hiroshi
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Job title
Doctor of Pharmaceutical Sciences(The University of Tokyo)
Research funding number

Research Areas


Academic & Professional Experience

Apr 2013
Leader, Molecular Glycobiology, Research team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Awards & Honors

Poster Award, The Japan Geriatrics Society
Elucidation of pathology and drug development for muscular dystrophy through the comprehension of novel glycosylation mechanisms, The PSJ Award for Divisional Scientific Promotion, The Pharmaceutical Society of Japan
Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production, JB Award
Winner: Akasaka-Manya K., Manya H., et al.
Role of N-glycans in maintaining the activity of protein O-mannosyltransferases POMT1 and POMT2, JB Award
Winner: Manya H., et al
Incentive award of The Japanese Society for Carbohydrate Research

Published Papers

Mechanisms of O-mannosyl glycan biosynthesis in mammals
Manya H
Trends in Glycoscience and Glycotechnology   31(181) SE63-SE64   2019   [Invited]
Imae R, Manya H, Tsumoto H, Osumi K, Tanaka T, Mizuno M, Kanagawa M, Kobayashi K, Toda T, Endo T
The Journal of biological chemistry   293(31) 12186-12198   Aug 2018   [Refereed]
Nishihara R, Kobayashi K, Imae R, Tsumoto H, Manya H, Mizuno M, Kanagawa M, Endo T, Toda T
Biochemical and biophysical research communications   497(4) 1025-1030   Mar 2018   [Refereed]
Manya H, Endo T
Biochimica et biophysica acta      Jul 2017   [Refereed]
Nagae M, Mishra SK, Neyazaki M, Oi R, Ikeda A, Matsugaki N, Akashi S, Manya H, Mizuno M, Yagi H, Kato K, Senda T, Endo T, Nogi T, Yamaguchi Y
Genes to cells : devoted to molecular & cellular mechanisms   22(4) 348-359   Apr 2017   [Refereed]
Akasaka-Manya K, Kawamura M, Tsumoto H, Saito Y, Tachida Y, Kitazume S, Hatsuta H, Miura Y, Hisanaga SI, Murayama S, Hashimoto Y, Manya H*, Endo T
Journal of biochemistry   161(1) 99-111   Jan 2017   [Refereed]
Manya H, Yamaguchi Y, Kanagawa M, Kobayashi K, Tajiri M, Akasaka-Manya K, Kawakami H, Mizuno M, Wada Y, Toda T, Endo T
The Journal of biological chemistry   291(47) 24618-24627   Nov 2016   [Refereed]
Yang H, Manya H, Kobayashi K, Jiao H, Fu X, Xiao J, Li X, Wang J, Jiang Y, Toda T, Endo T, Wu X, Xiong H
Journal of human genetics   61(8) 753-759   Aug 2016   [Refereed]
Kuwabara N, Manya H, Yamada T, Tateno H, Kanagawa M, Kobayashi K, Akasaka-Manya K, Hirose Y, Mizuno M, Ikeguchi M, Toda T, Hirabayashi J, Senda T, Endo T, Kato R
Proceedings of the National Academy of Sciences of the United States of America   113(33) 9280-9285   Aug 2016   [Refereed]
Xu M, Yamada T, Sun Z, Eblimit A, Lopez I, Wang F, Manya H, Xu S, Zhao L, Li Y, Kimchi A, Sharon D, Sui R, Endo T, Koenekoop RK, Chen R
Human molecular genetics   25(8) 1479-1488   Apr 2016   [Refereed]


Kanagawa M, Manya H
Glycobiology   27(7) 599-600   Jul 2017   [Refereed]
Geriatr. Gerontol. Int.   10(Supplement 1) S80-S87   2010
[Biosynthesis of O-mannosyl glycan in mammals].
Manya H, Endo T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   53 1429-1433   Sep 2008   [Refereed][Invited]
O-Mannosyltransferase and POMGnT1.
Experimental Glycoscience Glycobiology   30-32   2008
Method. Enzymol.   417 137-151   2006
O-Mannosylation in Mammalian Cells.
Protocol for Methods in Molecular Biology   347 43-55   2006
Fukutin and α-dystroglycanopahties.
Acta Myol.   14 60-63   2005
[Defective O-mannosyl glycosylation causes congenital muscular dystrophies].
Manya H, Endo T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   49 2451-2456   Nov 2004   [Refereed][Invited]

Books etc

Vitam Horm.
Akasaka-Manya K, Manya H, Endo T (Part:Contributor, Function and Change with Aging of α-Klotho in the Kidney.)
Elsevier   Mar 2016   
Sugar chains
Manya H, Endo T. (Part:Contributor, O-Mannosyl glycan and muscular dystrophy)
Springer   2015   
Handbook of Glycosyl transferases and related genes
Manya H, Endo T. (Part:Contributor, Protein O-linked-mannose β-1,2-N-acetyl glucosaminyltransferase 1 (POMGNT1), Protein O-mannosyl-transferase 1,2 (POMT1,2))
Springer   2014   

Research Grants & Projects

The biosynthetic mechanism of O-mannosyl glycan diversity
Project Year: 2016       Investigator(s): MANYA Hiroshi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2006 - 2008    Investigator(s): Hiroshi MANYA
The role of complex carbohydrate in vivo