2009年9月
Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas)
JOURNAL OF CONTROLLED RELEASE
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 138
- 号
- 2
- 開始ページ
- 128
- 終了ページ
- 133
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jconrel.2009.05.019
- 出版者・発行元
- ELSEVIER SCIENCE BV
Cell penetrating peptides (CPPs), including arginine-rich peptides, are attractive tools for the intracellular delivery of various bioactive molecules with a low membrane permeability. We showed that the accelerated intracellular delivery of arginine-rich peptides was achieved by the addition of a short peptide segment (penetration accelerating sequence, Pas) to arginine-rich CPPs. The cytosolic release of the Pas-attached arginine-rich CPPs was observed within 5 min after the treatment of the cells with the peptides even in the presence of serum. Effectiveness of the Pas segment in the intracellular delivery of bioactive peptides using arginine-rich CPPs was exemplified through the enhanced growth inhibition activity of the malignant glioma cells by a retro-inverso peptide derived from the p53 C-terminal 22-amino-acid segment (positions 361-382). All rights reserved. (C) 2009 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.jconrel.2009.05.019
- ISSN : 0168-3659
- eISSN : 1873-4995
- PubMed ID : 19465072
- Web of Science ID : WOS:000270926700006