Hiroto Mizushima

Profile Information

Affiliation: Research Institute for Microbial Diseases, Osaka University

Degree: (BLANK)(Yokohama City University)

J-GLOBAL ID: 201801012816979192
researchmap Member ID: B000307041

Research Interests

Research Areas

Research History

Sep, 2016 - Present

Specially Appointed Associate Professor, Research Institute for Microbial Diseases Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Osaka University
Apr, 2007 - Aug, 2016

Research Institute for Microbial Diseases, Osaka University
Nov, 2003 - Mar, 2007

Research Institute for Microbial Diseases, Osaka University
Apr, 2003 - Oct, 2003

Research Institute for Microbial Diseases, Osaka University
Apr, 2000 - Mar, 2003

Research Institute for Microbial Diseases, Osaka University
Jan, 2000 - Mar, 2000

Research Associate, Kurume University
Apr, 1998 - Mar, 1999

Postdoctoral fellow, The Burnham Institute
Apr, 1997 - Mar, 1998

Postdoctoral fellow, Yokohama City University

Education

Apr, 1994 - Mar, 1997

Graduate School, Division of Integrated Science, Yokohama City University
Apr, 1992 - Mar, 1994

Graduate School of Science and Technology, Tokyo University of Science
Apr, 1988 - Mar, 1992

Faculty of Science and Engineering, Tokyo University of Science

Papers

Spread of genetically similar noroviruses in Bangkok, Thailand, through symptomatic and asymptomatic individuals.

Patcharaporn Boonyos, Michittra Boonchan, Benjarat Phattanawiboon, Nutthawan Nonthabenjawan, Ratana Tacharoenmuang, Ratigorn Gunpapong, Phakapun Singchai, Sompong Upchai, Pimpha Rungnobhakhun, Jutarat Mekmullica …

Heliyon, 7(10) e08250-e08250, Oct 23, 2021 Peer-reviewedCorresponding author
Identification of GII.14[P7] norovirus and its genomic mutations from a case of long-term infection in a post-symptomatic individual

Nutthawan Nonthabenjawan, Patcharaporn Boonyos, Benjarat Phattanawiboon, Worakarn Towayunanta, Kobkool Chuntrakool, Karn Ngaopravet, Kriangsak Ruchusatsawat, Ballang Uppapong, Somchai Sangkitporn, Eisuke Mekada …

Infection, Genetics and Evolution, 86 104612-104612, Dec, 2020 Peer-reviewedLast authorCorresponding author
Anti-chikungunya virus monoclonal antibody that inhibits viral fusion and release

Uranan Tumkosit, Uamporn Siripanyaphinyo, Naokazu Takeda, Motonori Tsuji, Yusuke Maeda, Kriangsak Ruchusatsawat, Tatsuo Shioda, Hiroto Mizushima, Prukswan Chetanachan, Pattara Wongjaroen …

Journal of Virology, 94(19), Oct 1, 2020 Peer-reviewed
Norovirus transmission mediated by asymptomatic family members in households

Benjarat Phattanawiboon, Nutthawan Nonthabenjawan, Patcharaporn Boonyos, Chanya Jetsukontorn, Worakarn Towayunanta, Kobkool Chuntrakool, Karn Ngaopravet, Kriangsak Ruchusatsawat, Ballang Uppapong, Somchai Sangkitporn …

PLoS ONE, 15(7 July) e0236502, Jul, 2020 Peer-reviewedLast authorCorresponding author
The use of green fluorescent protein-tagged virus-like particles as a tracer in the early phase of chikungunya infection

Uranan Tumkosit, Yusuke Maeda, Natsuko Kishishita, Uamporn Siripanyaphinyo, Hiroko Omori, Prukswan Chetanachan, Pathompong Sittisaman, Chaitas Jityam, Thongkoon Priengprom, Hiroto Mizushima …

Virus Research, 272 197732, Oct 15, 2019 Peer-reviewed
The dynamics of norovirus genotypes and genetic analysis of a novel recombinant GII.P12-GII.3 among infants and children in Bangkok, Thailand between 2014 and 2016

Michittra Boonchan, Ratigorn Guntapong, Napas Sripirom, Kriangsak Ruchusatsawat, Phakapun Singchai, Pimpha Rungnobhakhun, Ratana Tacharoenmuang, Hiroto Mizushima, Masashi Tatsumi, Naokazu Takeda …

Infection, Genetics and Evolution, 60 133-139, Jun, 2018 Peer-reviewed
ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis

Ryo Iwamoto, Naoki Mine, Hiroto Mizushima, Eisuke Mekada

Journal of Cell Science, 130(7) 1321-1332, Apr, 2017 Peer-reviewed
BK-UM in patients with recurrent ovarian cancer or peritoneal cancer: A first-in-human phase-I study

Shingo Miyamoto, Fusanori Yotsumoto, Taeko Ueda, Tatsuya Fukami, Ayako Sanui, Kohei Miyata, Sung Ouk Nam, Satoshi Fukagawa, Takahiro Katsuta, Miyako Maehara …

BMC Cancer, 17(1) 89, Jan 31, 2017 Peer-reviewed
Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF

Keisuke Suzuki, Hiroto Mizushima, Hiroyuki Abe, Ryo Iwamoto, Haruki Nakamura, Eisuke Mekada

Journal of Biochemistry, 157(5) 331-343, May 1, 2015 Peer-reviewed
HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers

Takuya Murata, Takayuki Enomoto, Yutaka Ueda, Kiyoshi Yoshino, Shigeo Yagi, Robert M. Hoffman, Hiroto Mizushima, Tadashi Kimura, Eisuke Mekada

CANCER RESEARCH, 72, Apr, 2012 Peer-reviewed
HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers

Takuya Murata, Hiroto Mizushima, Ichino Chinen, Hiroki Moribe, Shigeo Yagi, Robert M. Hoffman, Tadashi Kimura, Kiyoshi Yoshino, Yutaka Ueda, Takayuki Enomoto …

Cancer Research, 71(21) 6633-6642, Nov 1, 2011 Peer-reviewed
Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells

Naohiko Koshikawa, Hiroto Mizushima, Tomoko Minegishi, Fuyuki Eguchi, Fusanori Yotsumoto, Kazuki Nabeshima, Shingo Miyamoto, Eisuke Mekada, Motoharu Seiki

Cancer Science, 102(1) 111-116, Jan, 2011 Peer-reviewed
Membrane type 1-matrix metalloproteinase cleaves off the NH <inf>2</inf>-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor

Naohiko Koshikawa, Hiroto Mizushima, Tomoko Minegishi, Ryo Iwamoto, Eisuke Mekada, Motoharu Seiki

Cancer Research, 70(14) 6093-6103, Jul 15, 2010 Peer-reviewed
Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures

Hiroto Mizushima, Xiaobiao Wang, Shingo Miyamoto, Eisuke Mekada

Journal of Cell Science, 122(23) 4277-4286, Dec 1, 2009 Peer-reviewedLead author
Efficacy of cross-reacting material 197 (CRM197), a specific inhibitor for heparin-binding epidermal growth factor-like growth factor (HB), in breast cancer patients

Yotsumoto F, Oki E, Tokunaga E, Maehara Y, Kuroki M, Mizushima H, Mekada E, Miyamoto S

Tumor Biol, 29(S1) 32-34, 2008 Peer-reviewed
Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity

Takuya Kageyama, Minako Ohishi, Shingo Miyamoto, Hiroto Mizushima, Ryo Iwamoto, Eisuke Mekada

Journal of Biochemistry, 142(1) 95-104, Jul, 2007 Peer-reviewed
FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts

Kyoko Kakumoto, Ken Sasai, Taiko Sukezane, Chitose Oneyama, Satoshi Ishimaru, Kana Shibutani, Hiroto Mizushima, Eisuke Mekada, Hidesaburo Hanafusa, Tsuyoshi Akagi

Proceedings of the National Academy of Sciences of the United States of America, 103(14) 5490-5495, Apr, 2006 Peer-reviewed
Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor

Xiaobiao Wang, Hiroto Mizushima, Satoshi Adachi, Minako Ohishi, Ryo Iwamoto, Eisuke Mekada

Cell Structure and Function, 31(1) 15-27, 2006 Peer-reviewed
Clinical significance of heparin-binding epidermal growth factor-like growth factor and A disintegrin and metalloprotease 17 expression in human ovarian cancer

Yoshihiro Tanaka, Shingo Miyamoto, Satoshi O. Suzuki, Eiji Oki, Hiroshi Yagi, Kenzo Sonoda, Ayano Yamazaki, Hiroto Mizushima, Yoshihiko Maehara, Eisuke Mekada …

Clinical Cancer Research, 11(13) 4783-4792, Jul 1, 2005 Peer-reviewed
Regulation of biological activity and matrix assembly of laminin-5 by COOH-terminal, LG4-5 domain of α3 chain

Yoshiaki Tsubota, Chie Yasuda, Yoshinobu Kariya, Takashi Ogawa, Tomomi Hirosaki, Hiroto Mizushima, Kaoru Miyazaki

Journal of Biological Chemistry, 280(15) 14370-14377, Apr, 2005 Peer-reviewed

Misc.

Membrane Type 1-Matrix Metalloproteinase Cleaves Off the NH2-Terminal Portion of Heparin-Binding Epidermal Growth Factor and Converts It into a Heparin-Independent Growth Factor

Naohiko Koshikawa, Hiroto Mizushima, Tomoko Minegishi, Ryo Iwamoto, Eisuke Mekada, Motoharu Seiki

CANCER RESEARCH, 70(14) 6093-6103, Jul, 2010
Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity

Takuya Kageyama, Minako Ohishi, Shingo Miyamoto, Hiroto Mizushima, Ryo Iwamoto, Eisuke Mekada

Journal of Biochemistry, 142(1) 95-104, Jul, 2007
Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity

Takuya Kageyama, Minako Ohishi, Shingo Miyamoto, Hiroto Mizushima, Ryo Iwamoto, Eisuke Mekada

JOURNAL OF BIOCHEMISTRY, 142(1) 95-104, Jul, 2007
FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts

K Kakumoto, K Sasai, T Sukezane, C Oneyama, S Ishimaru, K Shibutani, H Mizushima, E Mekada, H Hanafusa, T Akagi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(14) 5490-5495, Apr, 2006
FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts

K Kakumoto, K Sasai, T Sukezane, C Oneyama, S Ishimaru, K Shibutani, H Mizushima, E Mekada, H Hanafusa, T Akagi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(14) 5490-5495, Apr, 2006
Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor

Xiaobiao Wang, Hiroto Mizushima, Satoshi Adachi, Minako Ohishi, Ryo Iwamoto, Eisuke Mekada

CELL STRUCTURE AND FUNCTION, 31(1) 15-27, 2006
Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.

Xiaobiao Wang, Hiroto Mizushima, Satoshi Adachi, Minako Ohishi, Ryo Iwamoto, Eisuke Mekada

Cell Struct. Funct., 31(1) 15-27, 2006
TIMP-sensitive proteases are required for HB-EGF-induced tumorigenesis independent of mediating ectodomain shedding

Hiroto Mizushima, Xiobion Wan, Eisuke Mekada

CELL STRUCTURE AND FUNCTION, 29 75-75, May, 2004
Sole expression of laminin gamma 2 chain in invading tumor cells and its association with stromal fibrosis in lung adenocarcinomas

Y Kagesato, H Mizushima, N Koshikawa, H Kitamura, H Hayashi, N Ogawa, M Tsukuda, K Miyazaki

JAPANESE JOURNAL OF CANCER RESEARCH, 92(2) 184-192, Feb, 2001
Isolation and activity of proteolytic fragment of laminin-5 α3 chain

Yoshiaki Tsubota, Hiroto Mizushima, Tomomi Hirosaki, Shouichi Higashi, Hidetaro Yasumitsu, Kaoru Miyazaki

Biochemical and Biophysical Research Communications, 278(3) 614-620, Nov 30, 2000
The functions of exogenous and endogenous laminin-5 on corneal epithelial cells

N Ebihara, H Mizushima, K Miyazaki, Y Watanabe, S Ikawa, K Nakayasu, A Kanai

EXPERIMENTAL EYE RESEARCH, 71(1) 69-79, Jul, 2000
Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5

T Hirosaki, H Mizushima, Y Tsubota, K Moriyama, K Miyazaki

JOURNAL OF BIOLOGICAL CHEMISTRY, 275(29) 22495-22502, Jul, 2000
ラミニン-5の細胞運動促進活性におけるα3鎖Gドメインのプロテアーゼ

坪田芳明, 広崎智己, 水島寛人, 東昌市, 宮崎香

生化学, 72(8), 2000
ラミニン-5の細胞運動促進活性におけるα3鎖Gドメインのプロテアーゼ切断の意義

坪田芳明, 水島寛人, 東昌市, 宮崎香

Japanese Journal of Cancer Research, 91(Supplement (Sept)), 2000
Overexpression of laminin gamma 2 chain monomer in invading gastric carcinoma cells

K Miyazaki, N Koshikawa, K Moriyama, H Takamura, H Mizushima, Y Nagashima, S Yanoma

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 113(6) 1140-1140, Dec, 1999
Expression of Laminin γ 2 During Human Intestinal Morphogenesis :

Wei Lu, NEMOTO Norimichi, USHIYAMA Hisashi, KOSHIKAWA Naohiko, MIZUSHIMA Hiroto, MIYAZAKI Kaoru

Acta histochemica et cytochemica, 32(6) 547-547, 1999
ヒト組織基底膜におけるラミニン5γ2鎖の広範な分布

50 7-14, 1998
Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues

H Mizushima, N Koshikawa, K Moriyama, H Takamura, Y Nagashima, F Hirahara, K Miyazaki

HORMONE RESEARCH, 50(Supplement 2) 7-14, 1998
Identification of integrin-dependent and -independent cell adhesion domains in COOH-terminaI globular region of laminin-5 alpha 3 chain

H Mizushima, H Takamura, Y Miyagi, Y Kikkawa, N Yamanaka, H Yasumitsu, K Misugi, K Miyazaki

CELL GROWTH & DIFFERENTIATION, 8(9) 979-987, Sep, 1997
ラミニン-5α3鎖のカルボキシ末端領域におけるインテグリン依存的及び非依存的細胞接着ドメインの同定

(8) 979-987, 1997

Presentations

Follow-up study of noroviru infections in healthy persons in Thailand

Hiroto Mizushima

The 28th Annual Medical Sciences Conference, 2020, Aug, 2020 Invited

Research Projects

Development of a novel anti-cancer therapeutics targeting HB-EGF

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

MEKADA EISUKE, IWAMOTO Ryo, MIZUSHIMA Hiroto, NAKAMURA Takashi, YONEDA Tomoko
Integration and regulatory mechanism for growth factor and cell adhesion signals

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

MIZUSHIMA Hiroto, MEKADA Eisuke
Cell function regulation by membrane-anchored growth factors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

MEKADA Eisuke, IWAMOTO Ryo, ASANO Shiro, MIZUSHIMA Hiroto, NAKAMURA Kuniaki
Identification of genes involved in the ectodomain sheddingof HB-EGF

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2006 - 2007

MEKADA Eisuke, MIZUSHIMA Hiroto, ASANO Shiro
Analysis of the ectodomain shedding mechanism of HB-EGF

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2004 - 2005

MEKADA Eisuke, IWAMOTO Ryo, MIZUSHIMA Hiroto
Function of four transmembrane protein(tetraspanin) in vivo

The Other Research Programs
4回膜貫通タンパク質(テトラスパニン)の生体内における機能

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