髙島謙 (Takashima Ken) - マイポータル

基本情報

所属: 熊本大学大学院生命科学研究部免疫学講座助教

学位: 医学博士(北海道大学)

J-GLOBAL ID: 201701006876256990
researchmap会員ID: B000275265

研究キーワード

研究分野

経歴

2021年5月 - 現在

熊本大学, 大学院生命科学研究部免疫学講座, 助教
2021年4月 - 2021年4月

熊本大学, 大学院生命科学研究部免疫学講座, 文部科研研究員
2018年4月 - 2021年3月

Harvard Medical School / Boston Children's Hospital, Newborn Medicine, Postdoctoral fellow
2017年4月 - 2018年4月

北海道大学大学院, 医学研究院, 特任助教

学歴

2014年4月 - 2017年3月

北海道大学大学院, 医学研究科, 博士課程（MD-PhDコース）
2008年4月 - 2014年3月

北海道大学, 医学部, 医学科

受賞

論文

The nucleolar protein NOP16 suppresses TGF-β-regulated IgA class switch recombination in B cells by regulating AID induction

Yohana Silas Mtali, Ken Takashima, Eric Lieberman Greer, Hiroyuki Oshiumi

The Journal of Immunology 2026年5月14日査読有り責任著者
Lipid nanoparticle-encapsulated microRNA-192: An anti-inflammatory adjuvant that enhances vaccine efficacy in aged mice.

Yuriko Takagi, Tasuku Nishimura, Suraiya Aktar, Daisuke Katayama, Ken Takashima, Tomomi Kawakita, Toshiki Sekiya, Masashi Shingai, Hiroki Tanaka, Hidetaka Akita …

Molecular therapy. Nucleic acids 37(1) 102784-102784 2026年3月12日査読有り
A selective RPL15 PROTAC degrader enhances anti-PD-1 immunotherapy in a murine melanoma tumor model.

Runa Takahashi, Kazuki Yamamoto, Hikaru Toya, Haruka Shoji, Kohei Kawanishi, Kyoka Momosaki, Miyuki Yabe, Ken Takashima, Ryuta Muromoto, Satoshi Ichikawa …

Oncogene 44(50) 4846-4854 2025年12月査読有り
Nucleolar stress generates ribosomal DNA–derived RNA–DNA hybrids that prime innate immunity

Ken Takashima, Yohana Mtali, Akter Suraiya, Doreen Emily, Kenichi Miharada, Hiroyuki Oshiumi

Research Square (Preprint) 2025年10月16日筆頭著者責任著者
Regulation of IL-17A–mediated hypersensitivity by extracellular vesicles and lipid nanoparticles carrying miR-451a

Takanobu Yoshida, Ken Takashima, Yohana S Mtali, Yusuke Miyashita, Asuka Iwamoto, Yoshimi Fukushima, Kimitoshi Nakamura, Hiroyuki Oshiumi

The Journal of Immunology 2025年3月11日査読有り責任著者
Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs

Tasuku Nishimura, Takahisa Kouwaki, Ken Takashima, Akie Ochi, Yohana S Mtali, Hiroyuki Oshiumi

EMBO Reports 2024年12月12日査読有り筆頭著者
HPV vaccines induce trained immunity and modulate pro-inflammatory cytokine expression in response to secondary Toll-like receptor stimulations.

Mako Yamaguchi, Yohana S Mtali, Hitomi Sonokawa, Ken Takashima, Yoshimi Fukushima, Takahisa Kouwaki, Hiroyuki Oshiumi

Microbiology and immunology 2023年12月17日査読有り責任著者
NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression.

Ken Takashima, Dian-Jang Lee, María Fernanda Trovero, M Hafiz Rothi, Meeta Mistry, Ying Zhang, Zhouyihan Li, Christopher P Davis, Zilan Li, Julia Natale …

bioRxiv : the preprint server for biology 2023年6月13日筆頭著者
Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination.

Yusuke Miyashita, Takanobu Yoshida, Yuriko Takagi, Hirotake Tsukamoto, Ken Takashima, Takahisa Kouwaki, Katsunari Makino, Satoshi Fukushima, Kimitoshi Nakamura, Hiroyuki Oshiumi

NPJ vaccines 7(1) 16-16 2022年2月8日査読有り
Role of epigenetics in unicellular to multicellular transition in Dictyostelium.

Simon Yuan Wang, Elizabeth Ann Pollina, I-Hao Wang, Lindsay Kristina Pino, Henry L Bushnell, Ken Takashima, Colette Fritsche, George Sabin, Benjamin Aaron Garcia, Paul Lieberman Greer …

Genome biology 22(1) 134-134 2021年5月4日査読有り
Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome.

Konstantinos Boulias, Diana Toczydłowska-Socha, Ben R Hawley, Noa Liberman, Ken Takashima, Sara Zaccara, Théo Guez, Jean-Jacques Vasseur, Françoise Debart, L Aravind …

Molecular cell 75(3) 631-643 2019年8月8日査読有り
Vaccine immunotherapy with ARNAX induces tumor-specific memory T cells and durable anti-tumor immunity in mouse models.

Yohei Takeda, Sumito Yoshida, Ken Takashima, Noriko Ishii-Mugikura, Hiroaki Shime, Tsukasa Seya, Misako Matsumoto

Cancer science 109(7) 2119-2129 2018年7月査読有り
TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells.

Ken Takashima, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya

Biochemical and biophysical research communications 499(4) 985-991 2018年5月23日査読有り筆頭著者責任著者
Toll-like receptor 3 signal augments radiation-induced tumor growth retardation in a murine model.

Sumito Yoshida, Hiroaki Shime, Yohei Takeda, Jin-Min Nam, Ken Takashima, Misako Matsumoto, Hiroki Shirato, Masanori Kasahara, Tsukasa Seya

Cancer science 109(4) 956-965 2018年4月査読有り
Adjuvant immunotherapy for cancer: both dendritic cell-priming and check-point inhibitor blockade are required for immunotherapy.

Tsukasa Seya, Yohei Takeda, Ken Takashima, Sumito Yoshida, Masahiro Azuma, Misako Matsumoto

Proceedings of the Japan Academy. Series B, Physical and biological sciences 94(3) 153-160 2018年査読有り
DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70.

Ken Takashima, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya

Journal of innate immunity 10(1) 44-55 2018年査読有り筆頭著者責任著者
cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue.

Hiromi Takaki, Ken Takashima, Hiroyuki Oshiumi, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Misako Matsumoto, Tsukasa Seya

Medical sciences (Basel, Switzerland) 5(4) 2017年12月18日査読有り
The protein kinase RIOK3 suppressed MDA5-dependent innate immune response

Ken Takashima, Hiroyuki Oshiumi, Hiromi Takaki, Misako Matsurnoto, Tsukasa Seya

CYTOKINE 100 37-37 2017年12月査読有り筆頭著者
The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice.

Junya Ono, Hiroaki Shime, Hiromi Takaki, Ken Takashima, Kenji Funami, Sumito Yoshida, Yohei Takeda, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya

Journal of biomedical science 24(1) 79-79 2017年10月17日査読有り
STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.

Ken Takashima, Yohei Takeda, Hiroyuki Oshiumi, Hiroaki Shime, Masaru Okabe, Masahito Ikawa, Misako Matsumoto, Tsukasa Seya

Biochemical and biophysical research communications 478(4) 1764-71 2016年9月30日査読有り筆頭著者