Hiroshi Nagai

Profile Information

Affiliation: Associate Professor, Graduate School of Medicine Faculty of Medical Sciences, Kobe University

Degree: 博士（医学）(神戸大学)

J-GLOBAL ID: 200901084441194916
researchmap Member ID: 5000039777

Research Interests

Research Areas

Life sciences / Dermatology /

Education

- Mar, 1998

Graduate School of Medicine, Kobe University

Papers

Safety and Efficacy of the Sirolimus Gel for TSC Patients With Facial Skin Lesions in a Long-Term, Open-Label, Extension, Uncontrolled Clinical Trial.

Mari Wataya-Kaneda, Hiroshi Nagai, Yuuki Ohno, Hiroo Yokozeki, Yasuyuki Fujita, Hironori Niizeki, Kazue Yoshida, Masaaki Ogai, Yuichi Yoshida, Akihiko Asahina …

Dermatology and therapy, May 8, 2020 Peer-reviewed
Image Gallery: Antihelix red-violaceous macules in juvenile dermatomyositis associated with antimelanoma differentiation-associated protein 5 antibody.

H Nagai, C Nishigori

The British journal of dermatology, 182(3) e85, Mar, 2020 Peer-reviewed
Fas-FasL interaction in cytotoxic T cell-mediated vitiligo: The role of lesional expression of tumor necrosis factor-α and interferon-γ in Fas-mediated melanocyte apoptosis.

Haruki Jimbo, Hiroshi Nagai, Susumu Fujiwara, Noriko Shimoura, Chikako Nishigori

Experimental dermatology, 29(1) 61-70, Jan, 2020 Peer-reviewed
Agminated fibroblastic connective tissue nevus in a 1-year-old boy.

Marie Ohata, Susumu Fujiwara, Ai Yoshioka, Hiroshi Nagai, Shintaro Sugita, Nozomi Yamano, Yusuke Inoue, Chikako Nishigori

Pediatric dermatology, 36(6) 997-998, Nov, 2019 Peer-reviewed
Cutaneous granulomatous lesions in a patient with mucosa-associated lymphoid tissue (MALT) lymphoma.

Takeshi Fukumoto, Hiroshi Nagai, Hiroya Ichikawa, Kimikazu Yakusijin, Chikako Nishigori

The Australasian journal of dermatology, 60(3) e240-e242, Aug, 2019 Peer-reviewed
Case of histiocytosis with bone involvement of fingers successfully treated with peginterferon-α.

Haruki Jimbo, Susumu Fujiwara, Hiroshi Nagai, Chikako Nishigori

The Journal of dermatology, 46(3) e94-e95, Mar, 2019 Peer-reviewed
高安動脈炎に伴い結節性紅斑様皮疹を発症した幼児の1例

永井宏, 錦織千佳子, 山田琢, 中岸保夫, 室田浩之

皮膚の科学, 17(4) 216-217, Aug, 2018 Peer-reviewed
Sirolimus Gel Treatment vs Placebo for Facial Angiofibromas in Patients With Tuberous Sclerosis Complex: A Randomized Clinical Trial.

Mari Wataya-Kaneda, Yuuki Ohno, Yasuyuki Fujita, Hiroo Yokozeki, Hironori Niizeki, Masaaki Ogai, Kazuyoshi Fukai, Hiroshi Nagai, Yuichi Yoshida, Izumi Hamada …

JAMA dermatology, 154(7) 781-788, Jul 1, 2018 Peer-reviewed
4-(4-Hydroxyphenyl)-2-butanol (rhododendrol)-induced melanocyte cytotoxicity is enhanced by UVB exposure through generation of oxidative stress.

Noriko Goto, Mariko Tsujimoto, Hiroshi Nagai, Taro Masaki, Shosuke Ito, Kazumasa Wakamatsu, Chikako Nishigori

Experimental dermatology, 27(7) 754-762, Jul, 2018 Peer-reviewed
【色素沈着を伴う皮膚病】 <臨床例>トシリズマブによる長期間の治療効果を観察しえた多中心性Castleman病に伴う皮膚形質細胞増多症

寒川愛美, NAGAI HIROSHI, KATAYAMA YOSHIO, NISHIGORI CHIKAKO

皮膚病診療, 40(6) 587-590, Jun, 2018 Peer-reviewed
Exacerbation and Prolongation of Psoriasiform Inflammation in Diabetic Obese Mice: A Synergistic Role of CXCL5 and Endoplasmic Reticulum Stress.

Noriko Shimoura, Hiroshi Nagai, Susumu Fujiwara, Haruki Jimbo, Chikako Nishigori

The Journal of investigative dermatology, 138(4) 854-863, Apr, 2018 Peer-reviewed
Neutrophilic superficial eccrine ductitis: Proposal of a new disease concept.

Hiroshi Nagai, Chikako Nishigori

Pediatric dermatology, 35(2) e105-e109-e109, Mar, 2018 Peer-reviewed
Allergic contact dermatitis caused by Olanedine® (olanexidine gluconate), a new antiseptic.

Hiroshi Nagai, Hitoshi Fukuda

Contact dermatitis, 78(2) 164-165, Feb, 2018 Peer-reviewed
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.

Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim, Dongxu Fu, Ivana Apicella, Akhil Varshney, Reo Yasuma, Benjamin J Fowler, Elmira Baghdasaryan …

Nature medicine, 24(1) 50-61, Jan, 2018 Peer-reviewed
Gene Expression and Methylation Analysis in Melanomas and Melanocytes From the Same Patient: Loss of NPM2 Expression Is a Potential Immunohistochemical Marker for Melanoma.

Susumu Fujiwara, Hiroshi Nagai, Haruki Jimbo, Naoe Jimbo, Tomoyo Tanaka, Masukazu Inoie, Chikako Nishigori

Frontiers in oncology, 8 675-675, 2018 Peer-reviewed
ヒドロキシクロロキンによる多形紅斑型薬疹の発症が疑われたが、少量からの漸増プロトコールによって内服再開が可能となった円板状エリテマトーデスの1例

木谷美湖野, 松澤惇, 濱岡大, OGURA KANAKO, NAGAI HIROSHI, NISHIGORI CHIKAKO

皮膚の科学, 16(6) 404-410, Dec, 2017
Identification of a heterozygous p.Gly568Val missense mutation in the TRPV3 gene in a Japanese patient with Olmsted syndrome: In silico analysis of TRPV3.

Hiroshi Nagai, Yutaka Takaoka, Aki Sugano, Yuji Nakamachi, Seiji Kawano, Chikako Nishigori

The Journal of dermatology, 44(9) 1059-1062, Sep, 2017 Peer-reviewed
Contact anaphylaxis caused by Basic Blue 99 in hair dye.

Ken Washio, Keiko Ijuin, Atsushi Fukunaga, Hiroshi Nagai, Chikako Nishigori

Contact dermatitis, 77(2) 122-123, Aug, 2017 Peer-reviewed
磁化率強調画像で多発する低信号を呈した血管内大細胞型B細胞性リンパ腫の一例

下村雅浩, 立花久嗣, 梶本裕人, 千原典夫, 上田健博, Sekiguchi Kenji, 古和久朋, 苅田典生, 永井宏, 錦織千佳子 …

臨床神経学, 57(6号) 348, Jun, 2017
Interleukin (IL)-18, cooperatively with IL-23, induces prominent inflammation and enhances psoriasis-like epidermal hyperplasia.

Noriko Shimoura, Hiroshi Nagai, Susumu Fujiwara, Haruki Jimbo, Takayuki Yoshimoto, Chikako Nishigori

Archives of dermatological research, 309(4) 315-321, May, 2017 Peer-reviewed

Misc.

Identification of a heterozygous p.Gly568Val missense mutation in the TRPV3 gene in a patient with Olmsted syndrome: In silico analysis of TRPV3

H. Nagai, Y. Takaoka, A. Sugano, Y. Nakamachi, S. Kawano, C. Nishigori

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(5) S91-S91, May, 2017
Neonatal lupus erythematosus.

Naoto Yokogawa, Naofumi Sumitomo, Masaru Miura, Kazuhiko Shibuya, Hiroshi Nagai, Mikako Goto, Atsuko Murashima

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 40(2) 124-130, 2017 Peer-reviewed
A MILD CASE OF DOMINANT DYSTROPHIC EPIDERMOLYSIS BULLOSA DIAGNOSED BY NEXT-GENERATION SEQUENCING

Makoto Nagai, Chiharu Tominaga, Sakaguchi Yoshiko, Hiroshi Nagai, Noriko Ohgo, Chikako Nishigori, Kiyofumi Yamanishi

JOURNAL OF DERMATOLOGY, 41 59-59, Oct, 2014
LICHEN PLANUS PIGMENTOSUS-INVERSUS MANIFESTING AS EXTENSIVE BUT SPONTANEOUSLY REGRESSING LESIONS

Hiroshi Nagai, Chikako Nishigori

JOURNAL OF DERMATOLOGY, 41 114-114, Oct, 2014
CLINICAL IMPLICATION OF NEUTRALIZING ANTIBODIES TO ADALIMUMAB AND INFLIXIMAB AND THEIR CONCENTRATION IN THE TREATMENT FOR PSORIASIS

Rika Nishikawa, Hiroshi Nagai, Toshinori Bito, Mayumi Hatakeyama, Ayuko Kikusawa, Haruhisa Kanki, Yasuko Sarayama, Tetsuya Ikeda, Hitoshi Yoshizaki, Hidenobu Seto …

JOURNAL OF DERMATOLOGY, 41 12-12, Oct, 2014
A CASE OF CUTANEOUS ANGIOSARCOMA TREATED BY PAZOPANIB WITH AN EXCELLENT RESPONSE TO THE LUNG METASTASIS

Susumu Fujiwara, Hiroshi Nagai, Yuji Nakamachi, Seiji Kawano, Chikako Nishigori

JOURNAL OF DERMATOLOGY, 41 44-44, Oct, 2014
GENOME-WIDE ANALYSIS FOR METHYLATION STATUS AND GENE EXPRESSION OF MELANOMAS AND MELANOCYTES FROM THE SAME INDIVIDUAL

S. Fujiwara, Y. F. Wong, H. Nagai, S. Nishikawa, C. Nishigori

ANNALS OF ONCOLOGY, 24, Nov, 2013
Interleukin-17 and interleukin-27 exert opposite effects on tumor necrosis factor-alpha-mediated psoriasis related chemokine production in human keratinocytes

Susumu Fujiwara, Hiroshi Nagai, Shuntaro Oniki, Takayuki Yoshimoto, Chikako Nishigori

JOURNAL OF DERMATOLOGY, 39 232-232, Jun, 2012
Antimelanoma immunotherapy: clinical and preclinical applications of IL-12 family members.

Hiroshi Nagai, Shuntaro Oniki, Susumu Fujiwara, Takayuki Yoshimoto, Chikako Nishigori

Immunotherapy, 2(5) 697-709, Sep, 2010 Peer-reviewed
Antitumor activities of interleukin-27 on melanoma.

Hiroshi Nagai, Shuntaro Oniki, Susumu Fujiwara, Mingli Xu, Izuru Mizoguchi, Takayuki Yoshimoto, Chikako Nishigori

Endocrine, metabolic & immune disorders drug targets, 10(1) 41-6, Mar, 2010 Peer-reviewed
CCR7-mediated migration of dendritic cells through activation of Rho kinase is regulated by Src homology 2 domain-containing protein tyrosine phosphatase substrate 1

K. Ogura, S. Oniki, A. Fukunaga, H. Nagai, H. Okazawa, T. Matozaki, C. Nishigon, T. Horikawa

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128 S174-S174, Apr, 2008
Acquired unilateral melanocytic nevi in otherwise normal skin

Xijun Yu, Hiroshi Nagai, Chikako Nishigori, Tatsuya Horikawa

PIGMENT CELL & MELANOMA RESEARCH, 21(2) 320-320, Apr, 2008
【皮膚筋炎】ステロイド抵抗性小児皮膚筋炎の1例

Yamada Yozo, NAGAI HIROSHI, NISHIGORI CHIKAKO

皮膚科の臨床, 48巻, 7号, pp. 865-868, Jul, 2006 Peer-reviewed
Phosphatidylinositol 3-kinase/Akt-dependent and -independent protection against apoptosis in normal human melanocytes

M Oka, A Nakamura, M Fukunaga, T Bito, H Nagai, C Nishigori

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 124(4) A89-A89, Apr, 2005
SHPS-1/SIRP alpha regulates migration of Langerhans cells from epidermis to draining lymphnode

A Fukunaga, H Nagai, XJ Yu, T Noguchi, T Matozaki, C Nishigori, T Horikawa

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 121(5) 1236-1236, Nov, 2003

Books and Other Publications

皮膚症状110症例でみる内科疾患 / 膵疾患－皮下結節性脂肪壊死症

NAGAI HIROSHI, NISHIGORI CHIKAKO

日本医事新報, Sep, 2018
皮膚科臨床アセット 11 シミと白斑最新診療ガイド / メラノーマに伴う白斑の病態・診断・鑑別診断

Nagai Hiroshi

皮膚科臨床アセット 11 シミと白斑最新診療ガイド / メラノーマに伴う白斑の病態・診断・鑑別診断, Oct, 2012
皮膚科臨床アセット 11 シミと白斑最新診療ガイド / Sutton白斑の病態・診断・鑑別診断

Nagai Hiroshi

中山書店, Oct, 2012
Visual Dermatology （特集）サルコイドーシスの皮膚病変を知る / そう痒を伴う例

NAGAI, Hiroshi (Role: Joint author)

秀潤社, Apr, 2003

Presentations

107

乾癬～診断・治療時の留意事項と病診連携～

NAGAI HIROSHI

皮膚疾患講演会, Dec, 2018
頑癬様の連環状外観を呈した皮膚カンジダ症の1例

江﨑諒, NAGAI HIROSHI, NISHIGORI CHIKAKO

第69回日本皮膚科学会中部支部学術大会, Oct, 2018
Penile traumatic neuromaの1例

橋本真哉, FUJIWARA SUSUMU, NAGAI HIROSHI, NISHIGORI CHIKAKO

第469回日本皮膚科学会大阪地方会, Sep, 2018
扁平疣贅の周囲にサットン現象を呈した1例

NAKAMURA KOREFUMI, NAGAI HIROSHI, NISHIGORI CHIKAKO

第117回日本皮膚科学会総会, May, 2018
両側大転子部に発症したischemic fasciitisの1例

横山大輔, FUJIWARA SUSUMU, NAGAI HIROSHI, NISHIGORI CHIKAKO

第117回日本皮膚科学会総会, May, 2018
Sirolimus gel treatment for tuberous sclerosis complex involving facial angiofibromasand cephalic plaques: a multicenter randomized controlled trial

Mari Wataya-Kaneda, Yuuki Ohno, Yasuyuki Fujita, Hiroo Yokozeki, Hironori Niizeki, Masaaki Ogai, Kazuyoshi Fukai, Hiroshi Nagai, Yuichi Yoshida, Izumi Hamada, Taihei Hio, Kenji Shimizu, Hiroyuki Murota

IID2018(7th International Investigative Dermatology), May, 2018
高安動脈炎に伴い結節性紅斑様皮疹を発症した幼児の1例

Nagai Hiroshi, Nishigori Chikako, 山田琢

第466回日本皮膚科学会大阪地方会（片山一朗教授退官記念地方会）, Mar, 2018
同一患者由来の悪性黒色腫と正常色素細胞の遺伝子発現およびメチル化解析 ~診断マーカーとしてのNPM2の検討~

FUJIWARA SUSUMU, 神保晴紀, NAGAI HIROSHI, NISHIGORI CHIKAKO, JIMBO NAOE, 田中朋代, 井家益和

第28回日本色素細胞学会学術大会, 2018
膠原病の皮膚病変

Nagai Hiroshi

第32回日本臨床リウマチ学会（教育講演）, Dec, 2017, 日本臨床リウマチ学会 Invited
ベーチェット病の病態と最新の治療について

Nagai Hiroshi

神戸市難病団体連絡協議会主催医療相談会, Dec, 2017
Agminated fibroblastic connective tissue nevusの1例

大幡万里恵, 吉岡愛育, Fujiwara Susumu, Nagai Hiroshi, Nishigori Chikako, 山野希, 井上友介

第68回日本皮膚科学会中部支部学術大会, Oct, 2017
肝機能障害を合併したBCG接種による丘疹状結核疹の1例

大桑槙子, Nagai Hiroshi, Nishigori Chikako

第81回日本皮膚科学会東部支部学術大会, Sep, 2017
ベーチェット病の病態と最新の治療について

Nagai Hiroshi

尼崎市難病団体連絡協議会主催医療相談会, Sep, 2017
ガドリニウム造影剤（ガドブトロール）による遅延型アレルギー性薬疹の1例

Nagai Hiroshi, Nishigori Chikako

第81回日本皮膚科学会東部支部学術大会, Sep, 2017
Genome-wide DNA methylation analysis in melanocytes and melanomas from the sama individual.

Fujiwara Susumu, Nagai Hiroshi, Haruki Jinbo, Tomoyo Tanaka, Masugazu Inoue, Nishigori Chikako

IPCC 2017, Aug, 2017
豊富な粘液状基質を伴った左下腿腫瘍の1例

Nakano Eiji, Nagai Hiroshi, Nishigori Chikako

第32回日本皮膚悪性腫瘍学会学術大会, Jun, 2017
同一患者由来の悪性黒色腫と正常色素細胞のエピジェネティックス解析および新規診断マーカー探索

Fujiwara Susumu, Nagai Hiroshi, Nishigori Chikako, 小濵千裕, 田中朋代, 井家益和, 黄欣鋒, 西川伸一

第116回日本皮膚科学会総会, Jun, 2017
掌蹠に強い皮膚症状を認めた新生児エリテマトーデスの1例

春日菜月, Nagai Hiroshi, Nishigori Chikako, 山田琢

第116回日本皮膚科学会総会, Jun, 2017
皮膚エリテマトーデスに対するヒドロキシクロロキンの使用経験

Nagai Hiroshi

Lupus Erythematosus Meeting in Hyogo, May, 2017
Identification of a heterozygous p.Gly568Val missense mutation in the TRPV3 gene in a patient with Olmsted syndrome: In silico analysis of RPV3.

Nagai Hiroshi, Takaoka Yutaka, Sugano Aki, Yuji Nakamachi, Kawano Seiji, Nishigori Chikako

2017 SID Annual Meeting, Apr, 2017

Research Projects

美白剤の色素細胞障害性における酸化ストレスの関与

学術研究助成基金助成金／基盤研究(C), Apr, 2016 - Mar, 2019

錦織千佳子
悪性黒色腫、乾癬の新しい治療戦略におけるＩＬ－２３とＩＬ－２７の役割とその応用

学術研究助成基金助成金／基盤研究(C), Apr, 2013 - Mar, 2016

永井宏
悪性黒色腫、乾癬、円形脱毛症に対するＩＬ－２７の治療的有用性についての基礎的検討

科学研究費補助金／基盤研究(C), 2010

永井宏
ＩＬ‐２３によるマウスＢ１６Ｆ１０メラノーマに対する免疫遺伝子療法

科学研究費補助金／若手研究(B), 2005

永井宏

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