2015年
3-Nitro-2-pyridinesulfenyl-mediated solid-phase disulfide ligation in the synthesis of disulfide bond-containing cyclic peptides
ORGANIC & BIOMOLECULAR CHEMISTRY
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- 巻
- 13
- 号
- 11
- 開始ページ
- 3186
- 終了ページ
- 3189
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c5ob00030k
- 出版者・発行元
- ROYAL SOC CHEMISTRY
A new solid-phase disulfide ligation method is developed to prepare a disulfide peptide from two types of Cys-containing peptide fragments with minimum purification steps. In combination with the subsequent intramolecular amide bond formation, a cyclic nonapeptide, oxytocin, was efficiently synthesized as a fundamental model for more complex cyclic peptides.
- リンク情報
- ID情報
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- DOI : 10.1039/c5ob00030k
- ISSN : 1477-0520
- eISSN : 1477-0539
- Web of Science ID : WOS:000351062700003