2015年5月
Control of the basement membrane and cell migration by ADAMTS proteinases: Lessons from C. elegans genetics
MATRIX BIOLOGY
- ,
- 巻
- 44-46
- 号
- 開始ページ
- 64
- 終了ページ
- 69
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.matbio.2015.01.001
- 出版者・発行元
- ELSEVIER SCIENCE BV
The members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of secreted proteins, MIG-17 and GON-1, play essential roles in Caenorhabditis elegans gonadogenesis. The genetic and molecular analyses of these proteinases uncovered novel molecular interactions regulating the basement membrane (BM) during the migration of the gonadal leader cells. MIG-17, which is localized to the gonadal BM recruits or activates fibulin-1 and type IV collagen, which then recruits nidogen, thereby inducing the remodeling of the BM that is required for directional control of leader cell migration. GON-1 acts antagonistically with fibulin-1 to regulate the levels of type IV collagen accumulation in the gonadal BM, which facilitates active migration of the leader cells. The cooperative action of MIG-17 and GON-1 represents an excellent model for understanding the mechanisms of organogenesis mediated by ADAMTS proteinases. (C) 2015 Published by Elsevier
- リンク情報
- ID情報
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- DOI : 10.1016/j.matbio.2015.01.001
- ISSN : 0945-053X
- eISSN : 1569-1802
- PubMed ID : 25595837
- Web of Science ID : WOS:000357229500008