論文

査読有り
2009年11月

Role of C-Terminal Region of Yeast ADP/ATP Carrier 2 Protein: Dynamics of Flexible C-Terminal Arm

ANTICANCER RESEARCH
  • Kazuto Ohkura
  • ,
  • Hitoshi Hori
  • ,
  • Yasuo Shinohara

29
11
開始ページ
4897
終了ページ
4900
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
INT INST ANTICANCER RESEARCH

Background: The ADP/ATP carrier catalyzes the exchange of ADP and ATP across the inner mitochondrial membrane. Materials and Methods: The molecular dynamics of modeled yeast type 2 AAC (yAAC2) was analyzed and molecular parameters were determined. Results: The yAAC2 C-terminal moved flexibly and a negative electrostatic potential field (ESP) was located in the C-terminal region. The ESP field is always located in the C-terminal area during C-terminal truncation (d1-d9). Further C-terminal truncation occurred on field invagination into the core region (d11, d14, d16). The 2-6 C-terminal amino acid truncation did not affect the biological activity. The d7-d9 truncated mutants lost their biological function. Conclusion: A critical point in yAAC2 function was shown between d6 and d7 C-terminal truncation. The C-terminal structure of yAAC2 is thought to be involved in biological function control.

Web of Science ® 被引用回数 : 5

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20032454
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000273203300082&DestApp=WOS_CPL