Papers

Peer-reviewed
2016

Protective effect of composite earthworm powder against diabetic complications via increased fibrinolytic function and improvement of lipid metabolism in ZDF rats

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
  • Tomoko Kawakami
  • ,
  • Airi Fujikawa
  • ,
  • Yohei Ishiyama
  • ,
  • Michihiro Hosojima
  • ,
  • Akihiko Saito
  • ,
  • Masatoshi Kubota
  • ,
  • Shinobu Fujimura
  • ,
  • Motoni Kadowaki

Volume
80
Number
10
First page
1980
Last page
1989
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1080/09168451.2016.1166932
Publisher
TAYLOR & FRANCIS LTD

Thrombosis is the leading cause of mortality globally. It is not only a complication but also a risk factor for progression of diabetes. However, alternative oral therapies and prophylaxis with less adverse effect for thrombosis have not been well studied. In this study, composite powder containing earthworm (CEP) was used and its fibrinolytic activity was measured. CEP was found to have a high urokinase-type plasminogen activator like activity in an in vitro assay. It also had significantly shortened euglobulin clot lysis time (ECLT) at 4 and 24h after ingestion in Sprague Dawley rats. Zucker Diabetic Fatty rats were used to assess the effect of CEP on diabetes and diabetic nephropathy. After 10weeks of feeding, CEP significantly shortened ECLT and attenuated HbA1c, hepatic lipid accumulation, and urinary albumin excretion and improved glomerular mesangial matrix score. Therefore, CEP may have beneficial effects on diabetes and diabetic nephropathy.

Link information
DOI
https://doi.org/10.1080/09168451.2016.1166932
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27292184
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000383046300018&DestApp=WOS_CPL
ID information
  • DOI : 10.1080/09168451.2016.1166932
  • ISSN : 0916-8451
  • eISSN : 1347-6947
  • Pubmed ID : 27292184
  • Web of Science ID : WOS:000383046300018

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