2021年9月
Dietary supplementation with monosodium glutamate suppresses chemotherapy-induced downregulation of the t1r3 taste receptor subunit in head and neck cancer patients
Nutrients
- 巻
- 13
- 号
- 9
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/nu13092921
(Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer.
- リンク情報
-
- DOI
- https://doi.org/10.3390/nu13092921
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/34578798
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469378
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85113797712&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85113797712&origin=inward
- ID情報
-
- DOI : 10.3390/nu13092921
- eISSN : 2072-6643
- PubMed ID : 34578798
- PubMed Central 記事ID : PMC8469378
- SCOPUS ID : 85113797712