2009年12月
Significance of Des-gamma-carboxy Prothrombin Production in Hepatocellular Carcinoma
ACTA MEDICA OKAYAMA
- ,
- ,
- 巻
- 63
- 号
- 6
- 開始ページ
- 299
- 終了ページ
- 304
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.18926/AMO/31826
- 出版者・発行元
- OKAYAMA UNIV MED SCHOOL
Serum des-gamma-carboxy prothrombin (DCP) is commonly used to detect hepatocellular carcinoma (HCC). This review focuses on the clinical features of DCP-positive HCC and the molecular function of DCP in HCC. DCP-positive HCC demonstrates more aggressive clinicopathological features than DCP-negative HCC. Analysis of the biological effects of DCP revealed that DCP acts as a growth factor in both an autocrine and paracrine manner. DCP stimulates HCC cell proliferation through the Met-Janus kinase 1-signal transducer and activator of transcription 3 signaling pathway, whereas for vascular endothelial cells, it stimulates cell proliferation and migration through the kinase insert domain receptor-phospholipase C-gamma-mitogen-activated protein kinase signaling pathway.
- リンク情報
- ID情報
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- DOI : 10.18926/AMO/31826
- ISSN : 0386-300X
- PubMed ID : 20035286
- Web of Science ID : WOS:000273145900001