論文

査読有り
2014年

Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
  • Kazuya Fujihara
  • Ayumi Sugawara
  • Yoriko Heianza
  • Toshimi Sairenchi
  • Fujiko Irie
  • Hiroyasu Iso
  • Mikio Doi
  • Hitoshi Shimano
  • Hiroshi Watanabe
  • Hirohito Sone
  • Hitoshi Ota
  • 全て表示

21
11
開始ページ
1152
終了ページ
1169
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.5551/jat.22913
出版者・発行元
JAPAN ATHEROSCLEROSIS SOC

Aim: The levels of lipids, especially triglycerides (TG), and obesity are associated with diabetes mellitus (DM). Although typically measured in fasting individuals, non-fasting lipid measurements play an important role in predicting future DM. This study compared the predictive efficacy of lipid variables according to the fasting status and body mass index (BMI) category.
Methods: Data were collected for 39,196 nondiabetic men and 87,980 nondiabetic women 40-79 years of age who underwent health checkups in Ibaraki-Prefecture, Japan in 1993 and were followed through 2007. The hazard ratios (HRs) for DM in relation to sex, the fasting status and BMI were estimated using a Cox proportional hazards model.
Results: A total of 8,867 participants, 4,012 men and 4,855 women, developed DM during a mean follow-up of 5.5 years. TG was found to be an independent predictor of incident DM in both fasting and non-fasting men and non-fasting women. The multivariable-adjusted HR for DM according to the TG quartile (Q) 4 vs. Q1 was 1.18 (95% confidence interval (CI): 1.05, 1.34) in the non-fasting men with a normal BMI (18.5-24.9). This trend was also observed in the non-fasting women with a normal BMI. That is, the multivariable-adjusted HRs for DM for TG Q2, Q3 and Q4 compared with Q1 were 1.07 (95% CI: 0.94, 1.23), 1.17 (95% CI: 1.03, 1.34) and 1.48 (95% CI: 1.30, 1.69), respectively.
Conclusions: The fasting and non-fasting TG levels in men and non-fasting TG levels in women are predictive of future DM among those with a normal BMI. Clinicians must pay attention to those individuals at high risk for DM.

リンク情報
DOI
https://doi.org/10.5551/jat.22913
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25030050
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000348434800005&DestApp=WOS_CPL
ID情報
  • DOI : 10.5551/jat.22913
  • ISSN : 1340-3478
  • eISSN : 1880-3873
  • PubMed ID : 25030050
  • Web of Science ID : WOS:000348434800005

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