Papers

Peer-reviewed Corresponding author
Nov, 2014

Stability and Changes in Metabolically Healthy Overweight or Obesity and Risk of Future Diabetes: Niigata Wellness Study

OBESITY
  • Yoriko Heianza
  • ,
  • Kiminori Kato
  • ,
  • Satoru Kodama
  • ,
  • Akiko Suzuki
  • ,
  • Shiro Tanaka
  • ,
  • Osamu Hanyu
  • ,
  • Koji Sato
  • ,
  • Hirohito Sone

Volume
22
Number
11
First page
2420
Last page
2425
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/oby.20855
Publisher
WILEY-BLACKWELL

ObjectiveStability and changes in obesity and metabolic health status from a baseline period and longitudinally investigated their impact on predicting future diabetes were assessed.
MethodsStudied were 27,478 Japanese individuals without diabetes. Metabolically healthy (MH) was indicated by having 1 among impaired fasting glucose, hypertension, hypertriglyceridemia and low HDL cholesterol concentration. Metabolically abnormal (MA) was indicated by having 2 of those metabolic abnormalities. A cut-off value of BMI 25.0 defined overweight or obesity (O) or normal weight (NW). Hazard ratio (HR) for diabetes for a 6-year period was investigated after changes in phenotypes were assessed during the previous 2 years.
ResultsCompared with maintaining MH-NW, transitioning to MH-O from MH-NW resulted in a multivariate-adjusted HR of 1.96 (95% CI: 1.18, 3.25) for diabetes. With a stable MH-O the HR for diabetes was 2.59 (2.00, 3.34) while change from MH-O to MH-NW resulted in an HR of 1.30 (0.61, 2.76). Transitioning to MA-O from MH-O was associated with an HR of 7.09 (5.41, 9.30). With a stable MA-O the risk of diabetes was substantially elevated with an HR of 12.5 (10.5, 14.9).
ConclusionsExamining the transitory nature of apparently benign or unhealthy obese phenotypes was effective for differentiating high-risk individuals for future diabetes.

Link information
DOI
https://doi.org/10.1002/oby.20855
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25131796
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000344849400020&DestApp=WOS_CPL
ID information
  • DOI : 10.1002/oby.20855
  • ISSN : 1930-7381
  • eISSN : 1930-739X
  • Pubmed ID : 25131796
  • Web of Science ID : WOS:000344849400020

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