Papers

Peer-reviewed Corresponding author
Oct, 2014

High risk of failing eradication of Helicobacter pylori in patients with diabetes: A meta-analysis

DIABETES RESEARCH AND CLINICAL PRACTICE
  • Chika Horikawa
  • ,
  • Saroru Kodama
  • ,
  • Kazuya Fujihara
  • ,
  • Reiko Hirasawa
  • ,
  • Yoko Yachi
  • ,
  • Akiko Suzuki
  • ,
  • Osamu Hanyu
  • ,
  • Hitoshi Shimano
  • ,
  • Hirohito Sone

Volume
106
Number
1
First page
81
Last page
87
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.diabres.2014.07.009
Publisher
ELSEVIER IRELAND LTD

Aims: Eradication of Helicobacter pylori (HP) is an effective approach to improve intestinal symptoms and prevent gastric cancer. However, there has been concern that the presence of diabetes reduces the effectiveness of antibiotics. We performed this meta-analysis to investigate the effect of diabetes on the risk of failing eradication in patients with diabetes.
Methods: An electronic literature search was conducted using Biosis, MEDLINE, Embase, PASCAL, and SciSearch through November 30, 2012. Selected studies had to provide data on the number of individuals who received treatment for HP infection and on the failure of HP eradication in groups with and without diabetes. Two authors independently extracted relevant data.
Results: Data were obtained from 8 eligible studies (693 total participants including 273 participants with diabetes). Overall, the pooled risk ratio (RR) of failing HP eradication for diabetic patients compared with non-diabetic participants was 2.19 [95% CI, 1.65-2.90] (P < 0.001). Excluding the 2 studies that used a non-standard protocol for HP eradication, individuals with diabetes had a higher risk of failure of eradication compared to those without diabetes (RR = 2.31 [95% CI, 1.72-3.11]).
Conclusions: Current meta-analysis confirmed the higher risk of HP eradication failure in individuals with diabetes compared with those without diabetes, suggesting the necessity of prolonging treatment or developing a new regimen for HP eradication in patients with diabetes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Link information
DOI
https://doi.org/10.1016/j.diabres.2014.07.009
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25110103
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000342377800014&DestApp=WOS_CPL
ID information
  • DOI : 10.1016/j.diabres.2014.07.009
  • ISSN : 0168-8227
  • eISSN : 1872-8227
  • Pubmed ID : 25110103
  • Web of Science ID : WOS:000342377800014

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