論文

査読有り 責任著者 国際誌
2016年9月

Impact of individual components and their combinations within a family history of hypertension on the incidence of hypertension: Toranomon hospital health management center study 22.

Medicine
  • Risa Igarashi
  • Kazuya Fujihara
  • Yoriko Heianza
  • Masahiro Ishizawa
  • Satoru Kodama
  • Kazumi Saito
  • Shigeko Hara
  • Osamu Hanyu
  • Ritsuko Honda
  • Hiroshi Tsuji
  • Yasuji Arase
  • Hirohito Sone
  • 全て表示

95
38
開始ページ
e4564
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/MD.0000000000004564
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Although a family history (FH) of hypertension is a risk factor for the development of hypertension, only a few studies have investigated in detail the impact of individual components of an FH on incident hypertension. We investigated the impact of individual components and their combinations on the presence or development of hypertension considering obesity, smoking habits, physical activity, and other metabolic parameters.Studied were 12,222 Japanese individuals without hypertension (n = 9,766) and with hypertension (n = 2,456) at the baseline examination. The presence or incidence of hypertension during 5 years after a baseline examination was assessed by the presence of systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg or a self-reported history of clinician-diagnosed hypertension. In this prospective study, the odds ratio for incident hypertension was 1.39 (95% confidence interval [CI], 1.22, 1.59) for individuals with any FH of hypertension compared with those without such an FH. Individuals with an FH of hypertension in both parents and one or more grandparents had an odds ratio of 3.05 (95% CI 1.74, 5.36) for hypertension compared with those without an FH of hypertension. FH was associated with incident hypertension independently of other modifiable risk factors such as obesity, smoking, physical inactivity, hyperglycemia, hyperuricemia, and hypertriglyceridemia.A parental history of hypertension was an essential component within an FH for incident hypertension. FH of hypertension over two generations with both parents affected was the most important risk factor for incident hypertension. Although an FH is not a modifiable risk factor, modifying other risk factors could contribute to reducing the risk of hypertension even among individuals with a family history of hypertension.

リンク情報
DOI
https://doi.org/10.1097/MD.0000000000004564
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27661014
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044884
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000385539300004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1097/MD.0000000000004564
  • ISSN : 0025-7974
  • eISSN : 1536-5964
  • PubMed ID : 27661014
  • PubMed Central 記事ID : PMC5044884
  • Web of Science ID : WOS:000385539300004

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