Hiroo Takahashi

Profile Information

Affiliation: Medical Faculty, Kagawa University

Degree: Ph.D.(The Graduate University for Advanced Studies)

J-GLOBAL ID: 201201084712183007
researchmap Member ID: B000222068

External link: http://kaken.nii.ac.jp/ja/r/20390685

神経回路のがどのように形成され、維持されているのか？という点に興味を持ち、ニワトリ視覚系やマウス嗅覚系に関する研究を行ってきました。現在は、脳梗塞が起こった時に、神経細胞を守るために働く分子メカニズムに興味を持ち、研究を行っています。

Research Interests

Research Areas

Research History

Jan, 2022 - Present

Faculty of Medicine, Kagawa University
Oct, 2018 - Dec, 2021

Faculty of Medicine, Kagawa University
Mar, 2017 - Sep, 2018

Nara Medical University
Oct, 2006 - Feb, 2017

Nara Medical University
Oct, 2003 - Sep, 2006

National Institute for Basic Biology
Sep, 2003

The Graduate University for Advanced Studies

Education

Apr, 2000 - Sep, 2003

Department of Basic Biology, School of Life Science, The Graduate University for Advanced Studies

Papers

Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia.

S M Khaledur Rahman, Zahir Hussain, Katsuya Morito, Naoko Takahashi, Mohammad Mamun Sikder, Tamotsu Tanaka, Ken-Ichi Ohta, Masaki Ueno, Hiroo Takahashi, Tohru Yamamoto, Makoto Murakami, Toru Uyama, Natsuo Ueda

Biochimica et biophysica acta. Molecular and cell biology of lipids, 1867(12) 159222-159222, Dec, 2022
Molecular mechanisms underlying activity-dependent ischemic tolerance in the brain.

Hiroo Takahashi, Tohru Yamamoto, Akio Tsuboi

Neuroscience research, Oct 13, 2022
Ascending spinal tract formation in chick embryo originating from different spinal regions.

Yohei Kokudo, Takahiro Arakawa, Hiroo Takahashi, Hideki Kobara, Masaki Kamada, Kazushi Deguchi, Tetsuo Touge, Tsutomu Masaki, Tohru Yamamoto

Brain research, 1768 147595-147595, Oct 1, 2021
Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.

Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi

Proceedings of the National Academy of Sciences of the United States of America, 118(32), Aug 10, 2021
Retinal ganglion cell loss in kinesin-1 cargo Alcadein α deficient mice

Yuki Nakano, Kazuyuki Hirooka, Yoichi Chiba, Masaki Ueno, Daiki Ojima, Md Razib Hossain, Hiroo Takahashi, Tohru Yamamoto, Yoshiaki Kiuchi

Cell Death & Disease, 11(3), Mar, 2020 Peer-reviewed
MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis

Md Razib Hossain, Mostofa Jamal, Yu Tanoue, Daiki Ojima, Hiroo Takahashi, Takashi Kubota, Tuba M. Ansary, Asuka Ito, Naoko Tanaka, Hiroshi Kinoshita, Yasushi Kishimoto, Tohru Yamamoto

Neuroscience Letters, 716 134677-134677, Jan, 2020 Peer-reviewed
Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae

Yuka Takahashi, Hiroo Takahashi, Peter L. Stern, Tadaaki Kirita, Akio Tsuboi

Frontiers in Cellular Neuroscience, 13 343-343, Jul 31, 2019 Peer-reviewedCorresponding author
The Functional Role of Olfactory Bulb Granule Cell Subtypes Derived From Embryonic and Postnatal Neurogenesis.

Takahashi H, Yoshihara S, Tsuboi A

Frontiers in molecular neuroscience, 11 229, 2018 Peer-reviewed
A Subtype of Olfactory Bulb Interneurons Is Required for Odor Detection and Discrimination Behaviors

Hiroo Takahashi, Yoichi Ogawa, Sei-ichi Yoshihara, Ryo Asahina, Masahito Kinoshita, Tatsuro Kitano, Michiko Kitsuki, Kana Tatsumi, Mamiko Okuda, Kouko Tatsumi, Akio Wanaka, Hirokazu Hirai, Peter L. Stern, Akio Tsuboi

JOURNAL OF NEUROSCIENCE, 36(31) 8210-8227, Aug, 2016 Peer-reviewed
Molecular mechanisms regulating the dendritic development of newborn olfactory bulb interneurons in a sensory experience-dependent manner

Sei-Ichi Yoshihara, Hiroo Takahashi, Akio Tsuboi

Frontiers in Neuroscience, 9 514, 2016 Peer-reviewed
Identification and characterization of PKCP gamma, a kinase associated with SCA14, as an amyloidogenic protein

Hideyuki Takahashi, Naoko Adachi, Toshihiko Shirafuji, Sally Danno, Takehiko Ueyama, Michele Vendruscolo, Anton N. Shuvaev, Takuya Sugimoto, Takahiro Seki, Daizo Hamada, Kazuhiro Irie, Hirokazu Hirai, Norio Sakai, Naoaki Saito

HUMAN MOLECULAR GENETICS, 24(2) 525-539, Jan, 2015 Peer-reviewed
Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons

Sei-ichi Yoshihara, Hiroo Takahashi, Nobushiro Nishimura, Masahito Kinoshita, Ryo Asahina, Michiko Kitsuki, Kana Tatsumi, Yoko Furukawa-Hibi, Hirokazu Hirai, Taku Nagai, Kiyofumi Yamada, Akio Tsuboi

CELL REPORTS, 8(3) 843-857, Aug, 2014 Peer-reviewed
嗅覚系におけるCO_2センシングの分子機構 : CO_2センシング

高橋弘雄, 坪井昭夫

化学と生物, 51(7) 438-440, Jul 1, 2013
5T4 Glycoprotein Regulates the Sensory Input-Dependent Development of a Specific Subtype of Newborn Interneurons in the Mouse Olfactory Bulb

Sei-ichi Yoshihara, Hiroo Takahashi, Nobushiro Nishimura, Hiromi Naritsuka, Taichi Shirao, Hirokazu Hirai, Yoshihiro Yoshihara, Kensaku Mori, Peter L. Stern, Akio Tsuboi

JOURNAL OF NEUROSCIENCE, 32(6) 2217-2226, Feb, 2012 Peer-reviewed
Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb

Hiroo Takahashi, Sei-ichi Yoshihara, Hirofumi Nishizumi, Akio Tsuboi

MOLECULAR AND CELLULAR NEUROSCIENCE, 44(3) 233-245, Jul, 2010 Peer-reviewed
Functional mode of FoxD1/CBF2 for the establishment of temporal retinal specificity in the developing chick retina

Hiroo Takahashi, Hiraki Sakuta, Takafumi Shintani, Masaharu Noda

DEVELOPMENTAL BIOLOGY, 331(2) 300-310, Jul, 2009 Peer-reviewed
Role of bone morphogenic protein 2 in retinal patterning and retinotectal projection

Hiraki Sakuta, Hiroo Takahashi, Takafumi Shintani, Kazuma Etani, Akihiro Aoshima, Masaharu Noda

JOURNAL OF NEUROSCIENCE, 26(42) 10868-10878, Oct, 2006 Peer-reviewed
Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O

T Shintani, M Ihara, H Sakuta, H Takahashi, Watakabe, I, M Noda

NATURE NEUROSCIENCE, 9(6) 761-769, Jun, 2006 Peer-reviewed
発生期のニワトリ網膜において領域特異的に発現する分子の網羅的同定と解析(Large-scale identification and characterization of genes with asymmetric expression patterns in the developing chick retina)

新谷隆史, 加藤彰, 湯浅純一, 作田拓, 高橋正和, 鈴木亮子, 大河原剛, 高橋弘雄, 野田昌晴

神経化学, 43(2-3) 522-522, Aug, 2004
Large-scale identification and characterization of genes with asymmetric expression patterns in the developing chick retina

T Shintani, A Kato, J Yuasa-Kawada, H Sakuta, M Takahashi, R Suzuki, T Ohkawara, H Takahashi, M Noda

JOURNAL OF NEUROBIOLOGY, 59(1) 34-47, Apr, 2004 Peer-reviewed

Misc.

A specific subtype of olfactory bulb interneurons is necessary for odor detection and odor-background segregation

Hiroo Takahashi, Sei-ichi Yoshihara, Yoichi Ogawa, Ryo Asahina, Tatsuro Kitano, Akio Tsuboi

CHEMICAL SENSES, 41(9) E148-E148, Nov, 2016
Molecular Mechanisms Regulating the Dendritic Development of Newborn Olfactory Bulb Interneurons in a Sensory Experience-Dependent Manner

Sei-ichi Yoshihara, Hiroo Takahashi, Akio Tsuboi

FRONTIERS IN NEUROSCIENCE, 9, Jan, 2016
嗅覚系におけるCO₂センシングの分子機構 (特集バイオセンサ)

高橋弘雄, 坪井昭夫

におい・かおり環境学会誌, 46(3) 209-217, May, 2015
Characterization of newborn interneurons in the mouse olfactory bulb using postnatal electroporation

Hiroo Takahashi, Sei-Ichi Yoshihara, Ryo Asahina, Yoshiki Tamada, Akio Tsuboi

Electroporation Methods in Neuroscience, 93-103, Mar 9, 2015 Peer-reviewed
転写因子Npas4による感覚入力依存的な嗅球介在ニューロンのシナプス形成の分子機構

吉原誠一, 高橋弘雄, 西村信城, 木下雅仁, 朝比奈諒, 日比陽子, 永井拓, 山田清文, 坪井昭夫

日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
Npas4 regulates the expression of Mdm2 that ubiquitinates Dcx to remodel dendritic spines in olfactory bulb interneurons after sensory experience.

Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki M, Tatsumi K, Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A

Cell Rep, 8 1-15, 2014 Peer-reviewed
嗅球介在ニューロンによる感覚入力依存的な神経回路再編の分子機構

吉原誠一, 高橋弘雄, 平井宏和, 吉原良浩, 森憲作, Stern Peter L., 坪井昭夫

Journal of Nara Medical Association, 64(1・2・3) 46-47, Jun, 2013
Characterization of the neural curcuit that elicits pleasure by food odor

(26) 1-5, 2013
5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb

Sei-ichi Yoshihara, Hiroo Takahashi, Kensaku Mori, Peter L. Stern, Akio Tsuboi

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 30(8) 684-684, Dec, 2012
嗅覚系における神経回路形成とCO₂センシングの分子機構

高橋弘雄, 坪井昭夫

日本応用酵素協会誌, (46) 23-30, Feb 1, 2012
Molecular Mechanisms Underlying Olfactory Sensory Map Formation in the Brain

TAKAHASHI HIROO, TSUBOI AKIO

Foods & Food Ingred J Jpn, 216(2) 100-106-106, May 1, 2011
Oncofetal protein 5T4 regulates the dendrite arborization of olfactory bulb interneurons in an odor-evoked activity-dependent process

Sei-ichi Yoshihara, Hiroo Takahashi, Nobushiro Nishimura, Masahito Kinoshita, Kensaku Mori, Peter L. Stern, Akio Tsuboi

NEUROSCIENCE RESEARCH, 71 E239-E239, 2011
Sensory input regulates the dendrite arborization of newborn olfactory bulb neurons via oncofetal protein 5T4

Akio Tsuboi, Hiroo Takahashi, Kensaku Mori, Peter L. Stern, Sei-ichi Yoshihara

NEUROSCIENCE RESEARCH, 71 E33-E33, 2011
Time-lapse imaging of neuronal migration in the mouse olfactory bulb

Hiroo Takahashi, Sei-ichi Yoshihara, Hitoki Nanaura, Akio Tsuboi

NEUROSCIENCE RESEARCH, 71 E239-E239, 2011
Molecular basis of CO2 sensing in the mouse olfactory system

Hiroo Takahashi, Hitoki Nanaura, Sei-ichi Yoshihara, Takeshi Imai, Junzo Hirono, Takaaki Sato, Akio Tsuboi

NEUROSCIENCE RESEARCH, 68 E98-E98, 2010
Activity-dependent development of olfactory bulb interneurons upon the neural circuit formation

Seiichi Yoshihara, Nobushiro Nishimura, Hiroo Takahashi, Kensaku Mori, Akio Tsuboi

NEUROSCIENCE RESEARCH, 68 E92-E92, 2010
Neural Patterning: Eye Fields

M. Noda, H. Takahashi, H. Sakuta

Encyclopedia of Neuroscience, 199-204, 2010
Mechanism underlying the olfactory sensory map formation in the brain

Aroma research, 11(3) 224-229, 2010
Activity-dependent development of olfactory bulb interneurons upon neural circuit formation

Seiichi Yoshihara, Hiroo Takahashi, Akio Tsuboi

NEUROSCIENCE RESEARCH, 65 S44-S45, 2009
Molecular basis of CO2 sensing in the mouse olfactory system

Hiroo Takahashi, Sei-ichi Yoshihara, Akio Tsuboi

NEUROSCIENCE RESEARCH, 65 S71-S71, 2009

Professional Memberships

Research Projects

神経活動依存的な転写因子Npas4が脳梗塞から脳を守るメカニズムの解明

科学研究費補助金(基盤研究(C)), 文部科学省, Apr, 2018 - Mar, 2021

高橋弘雄
新生嗅球介在ニューロンによる嗅覚行動の制御機構の解析

科学研究費補助金(基盤研究(C)), 文部科学省, Apr, 2015 - Mar, 2017

高橋弘雄
嗅球の神経回路新生を支える血管-神経相互作用の解析

科学研究費補助金(基盤研究(C)), 基盤研究(C), 文部科学省, Apr, 2012 - Mar, 2014

高橋弘雄
新生される嗅球介在ニューロンの移動を支える血管―神経相互作用の解析

科学研究費補助金(新学術領域研究(研究領域提案型)), 新学術領域研究(研究領域提案型), 文部科学省, 2011 - 2012

高橋弘雄
マウス嗅覚系におけるCO2センサー細胞の発達と機能の分子機構

科学研究費補助金(若手研究(B)), 若手研究(B), 文部科学省, 2010 - 2011

高橋弘雄
マウス嗅覚系におけるCO2センサーの新規動作機構の解明

科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2009 - 2010

坪井昭夫, 吉原誠一, 高橋弘雄
Generation, differentiation and integration of neural stem cells into neural circuits in the adult olfactory system

Grants-in-Aid for Scientific Research(基盤研究(C)), 基盤研究(C), Ministry of Education, Culture, Sports, Science and Technology, 2008 - 2010

Akio TSUBOI, Seiichi YOSHIHARA, Hiroo TAKAHASHI
Molecular mechanisms based on the regional specificity of olfactory sensory neurons.

Grants-in-Aid for Scientific Research(若手研究(B)), 若手研究(B), Ministry of Education, Culture, Sports, Science and Technology, 2008 - 2009

Hiroo TAKAHASHI
網膜内領域特異化の分子機構

科学研究費補助金(若手研究(B)), 若手研究(B), 文部科学省, 2005 - 2006

高橋弘雄

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Research History

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