Hiroshi Takikawa

Profile Information

Affiliation: Associate Professor, Graduate School of Pharmaceutical Sciences, Kyoto University

Degree: B.S. of Engineering(Nagoya University)
M.S. of Science(Tokyo Institute of Technology)
Ph.D. of Science(Tokyo Institute of Technology)

Researcher number: 70550755
ORCID ID: https://orcid.org/0000-0002-4414-2129
J-GLOBAL ID: 200901061626250480
researchmap Member ID: 5000093806

Research Interests

Research Areas

Research History

Nov, 2023 - Present

Associate Professor, Graduate School of Pharmaceutical Sciences, Kyoto University
May, 2017 - Oct, 2023

Lecturer, Graduate School of Pharmaceutical Sciences, Kyoto University
Aug, 2021 - Jul, 2023

Program Officer, Research Promotion Bureau, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
Apr, 2016 - May, 2017

Assistant Professor, Department of Chemistry, Tokyo Institute of Technology
Apr, 2009 - Mar, 2016

Assistant Professor, Department of Chemistry, Tokyo Institute of Technology
Apr, 2008 - Mar, 2009

Research Fellowships for Young Scientists (PD), Japan Society for the Promotion of Science
Apr, 2008 - Mar, 2009

Postdoctoral Fellow, Max-Planck-Institut für Kohlenforschung, Germany
Apr, 2005 - Mar, 2008

Research Fellowships for Young Scientists (DC1), Japan Society for the Promotion of Science

Education

Apr, 2003 - Mar, 2008

Department of Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology
Apr, 1999 - Mar, 2003

Chemical and Biological Engineering, School of Engineering, Nagoya University

Committee Memberships

Apr, 2018 - Mar, 2020

専門調査員, 文部科学省科学技術・学術政策研究所（NISTEP）
Apr, 2018 - Mar, 2020

ファルマシアトピックス小委員会編集委員, 日本薬学会

Awards

Dec, 2020

Journals Award 2021, Thieme Chemistry

Hiroshi Takikawa
Dec, 2020

Shionogi Pharma Co. Award in Synthetic Organic Chemistry, Society of Synthetic Organic Chemistry
Dec, 2019

Incentive Award in Synthetic Organic Chemistry, Society of Synthetic Organic Chemistry of Japan, Japan
Mar, 2018

The 32th Special Young LecturerSpecial Young Lecturer in the 98th CSJ Annual Meeting, The Chemical Society of Japan

TAKIKAWA Hiroshi
Aug, 2016

BCSJ Award Article

TAKIKAWA Hiroshi
Jul, 2016

第16回天然物化学談話会奨励賞

瀧川紘
Dec, 2009

26th Inoue Research Award for Young Scientists, Inoue Foundation for Science

TAKIKAWA Hiroshi

Papers

Structure–ATPase Activity Relationship of Rhodamine Derivatives as Potent Inhibitors of P-Glycoprotein CmABCB1

Sorachi Miwa, Hiroshi Takikawa, Rina Takeuchi, Ryo Mizunuma, Keita Matsuoka, Haruo Ogawa, Hiroaki Kato, Kiyosei Takasu

ACS Medicinal Chemistry Letters, Feb 8, 2024
Sequential Bromination/Dearomatization Reactions of 2-Methoxyphenols en route to Bromo-Substituted ortho -Quinonemonoacetals

Shunya Hayashi, Kiyosei Takasu, Hiroshi Takikawa

SYNLETT, Aug, 2023
Intramolecular Ynamide-Benzyne (3+2) Cycloadditions

Tsukasa Tawatari, Ritsuki Kato, Riku Kudo, Kiyosei Takasu, Hiroshi Takikawa

Angewandte Chemie (International ed. in English), e202300907, Mar 9, 2023
Synthesis of γ-Aryl Medium-Sized Cyclic Enones by a Domino 4π-Electrocyclic Reaction/Heck–Matsuda Arylation Sequence at Ambient Temperature

Kiyosei Takasu, Tomohiro Ito, Nao Takeuchi, Yousuke Yamaoka, Hiroshi Takikawa

Synlett, 34(11) 1275-1279, Feb 1, 2023
Intramolecular Propargylic Ene Reaction of Benzyne en Route to Highly Functionalized Allenes and Allenamides

Tsukasa Tawatari, Ritsuki Kato, Kiyosei Takasu, Hiroshi Takikawa

Synthesis, Apr 14, 2022
2-(Chlorodiisopropylsilyl)-6-(trimethylsilyl)phenyl triflate: a modified platform for intramolecular benzyne cycloadditions

Tsukasa Tawatari, Kiyosei Takasu, Hiroshi Takikawa

CHEMICAL COMMUNICATIONS, 57(89) 11863-11866, Nov, 2021
Oxidative β-Cleavage of Fused Cyclobutanols Leading to Hydrofuran-Fused Polycyclic Aromatic Compounds

Hayate Kinouchi, Kazuma Sugimoto, Yousuke Yamaoka, Hiroshi Takikawa, Kiyosei Takasu

The Journal of Organic Chemistry, Sep 17, 2021
Synthesis of Lactone-Fused Cyclopropanes by Ring Contractive α-Ketol Rearrangement of Ketal-Fused Cyclobutanones

Kiyosei Takasu, Koichi Shigenaga, Kazuma Shimoda, Hiroshi Takikawa, Yousuke Yamaoka

HETEROCYCLES, 103(1) 177-177, 2021
Synthetic Study on Acremoxanthone A, Part 2: Model Study on the EFG Xanthone Moiety through a Nitrile Oxide Cycloaddition–SNAr Sequence

Keisuke Suzuki, Hiroshi Nakakohara, Yoichi Hirano, Ken Ohmori, Hiroshi Takikawa

Synlett, Nov 4, 2020
Synthetic Study on Lactonamycins, Part 2: Stereoselective Access to ABCD-Ring System

Keisuke Suzuki, Hiroshi Takikawa, Kazuki Murata, Shogo Sato, Takuma Kawada, Hiroshi Nakakohara, Ken Ohmori

Synlett, 31(16) 1623-1628, Jul 21, 2020 Peer-reviewed
Helical Nanographenes Embedded with Contiguous Azulene Units

Naoki Ogawa, Yousuke Yamaoka, Hiroshi Takikawa, Ken-ichi Yamada, Kiyosei Takasu

Journal of the American Chemical Society, 142(31) 13322-13327, Jul 17, 2020 Peer-reviewed
Intramolecular Benzyne-Phenolate [4+2] Cycloadditions.

Hiroshi Takikawa, Arata Nishii, Hiromu Takiguchi, Hirotoshi Yagishita, Masato Tanaka, Keiichi Hirano, Masanobu Uchiyama, Ken Ohmori, Keisuke Suzuki

Angewandte Chemie (International ed. in English), 59(30) 12440-12444, Apr 9, 2020 Peer-reviewed
Synthesis of Dibenzoxazonines by Domino [2+2] Cycloaddition—4π Electrocyclic Ring Opening Reaction of Cyclic Imines with Ynamides

Kiyosei Takasu, Masaki Tsutsumi, Tomohiro Ito, Hiroshi Takikawa, Yousuke Yamaoka

HETEROCYCLES, 101(2) 423-423, 2020 Peer-reviewed
Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides, and Echinocidins

Shimoda K, Yamaoka Y, Yoo D, Yamada KI, Takikawa H, Takasu K

The Journal of Organic Chemistry, 84(17) 11014-11024, Sep, 2019 Peer-reviewed
Synthesis of Polycyclic Spirocarbocycles via Acid-Promoted Ring-Contraction/Dearomative Ring-Closure Cascade of Oxapropellanes

Ogawa N, Yamaoka Y, Takikawa H, Takasu K

Organic Letters, 21(18) 7563-7567, Sep, 2019 Peer-reviewed
Synthesis of Functionalized Medium-Sized trans -Cycloalkenes by 4π Electrocyclic Ring Opening/Alkylation Sequence

Tomohiro Ito, Masaki Tsutsumi, Ken-ichi Yamada, Hiroshi Takikawa, Yousuke Yamaoka, Kiyosei Takasu

Angewandte Chemie International Edition, 58(34) 11836-11840, Aug, 2019 Peer-reviewed
2-Bromo-6-(chlorodiisopropylsilyl)phenyl tosylate as an efficient platform for intramolecular benzyne-diene [4+2] cycloaddition

Nishii Arata, Takikawa Hiroshi, Suzuki Keisuke

CHEMICAL SCIENCE, 10(13) 3840-3845, Apr 7, 2019 Peer-reviewed
Synthetic Strategy toward Dearomatized Polycyclic Polyketide Natural Products

Hiroshi Takikawa, Keisuke Suzuki

Journal of Synthetic Organic Chemistry, Japan, 77(1) 13-25, Jan 1, 2019
Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds

Takikawa Hiroshi, Nishii Arata, Sakai Takahiro, Suzuki Keisuke

CHEMICAL SOCIETY REVIEWS, 47(21) 8030-8056, Nov 7, 2018 Peer-reviewed
Total Synthesis of Bis-anthraquinone Antibiotic BE-43472B

Yu Yamashita, Yoichi Hirano, Akiomi Takada, Hiroshi Takikawa, Keisuke Suzuki

Synthesis (Germany), 50(13) 2490-2515, Jul 2, 2018 Peer-reviewed

Misc.

ABCトランスポーターとの共結晶形成を指向したローダミン誘導体の合成と評価

三和空知, 瀧川紘, 竹内莉奈, 小田島圭, 水沼諒, 山岡庸介, 潘東青, 加藤博章, 高須清誠

次世代を担う有機化学シンポジウム講演要旨集, 20th, 2022
Benzyne platform for intramolecular ene reaction, part 2: Application to expeditious synthesis of highly functionalized allenamides

田渡司, 加藤律希, 山岡庸介, 高須清誠, 瀧川紘

日本薬学会年会要旨集(Web), 142nd, 2022
Benzyne platform for intramolecular ene reaction, part 1: Application to stereoselective arylation of allyl alcohols

瀧川紘, 加藤律希, 田渡司, 山岡庸介, 高須清誠

日本薬学会年会要旨集(Web), 142nd, 2022
Synthesis and optical properties of helicene-xanthene hybrid dyes

三和空知, 水谷大地, 山岡庸介, 高須清誠, 瀧川紘

日本薬学会年会要旨集(Web), 142nd, 2022
Photoinduced domino reaction of ynamide leading to N-heterocycles

山岡庸介, 梶原大悟, 瀧川紘, 高須清誠

日本薬学会年会要旨集(Web), 142nd, 2022
Synthesis and Chromic properties of Hydroxyfluoranthenes

黒川宗希, 小川直希, 山岡庸介, 瀧川紘, 高須清誠

日本薬学会年会要旨集(Web), 142nd, 2022
Identification of substrate binding sites in P-glycoprotein, CmABCB1 with affinity-labeling

小田島圭, PAN Dongqing, 三和空知, 水沼諒, 瀧川紘, 高須清誠, 加藤博章, 加藤博章

日本薬学会年会要旨集(Web), 141st, 2021
Total Synthesis of Cryptopleurine Derivatives and their Bioactivity Evaluation

山岡庸介, 立石海斗, 山川拓朗, 服部明, 瀧川紘, 掛谷秀昭, 高須清誠

日本薬学会年会要旨集(Web), 141st, 2021
Expeditious synthesis of dibromo-ortho-quinonemonoacetals via bromination/dearomaization sequence

瀧川紘, 林隼矢, 大山侃志, 山岡庸介, 高須清誠

日本薬学会年会要旨集(Web), 141st, 2021
Oxidative β-cleavage of a cyclobutane ring of polycyclic cyclobutanols

高須清誠, 紀之内颯, 山岡庸介, 瀧川紘

日本薬学会年会要旨集(Web), 141st, 2021
2-(Chlorodiisopropylsilyl)-6-(trimethylsilyl)phenyl Triflate: A Novel Platform for Intramolecular Benzyne Reactions

瀧川紘, 田渡司, 山岡庸介, 高須清誠

日本薬学会年会要旨集(Web), 141st, 2021
分子ひずみを利用した官能基化多環芳香族化合物の合成

紀之内颯, 山岡庸介, 瀧川紘, 高須清誠

創薬懇話会講演要旨集, 2021, 2021
イナミドのドミノ反応を用いた複雑アルカロイド骨格の構築

山岡庸介, 山崎大資, 梶原大悟, 瀧川紘, 高須清誠

創薬懇話会講演要旨集, 2021, 2021
アズレン含有ナノグラフェンの合成と性質

小川直希, 黒川宗希, 山岡庸介, 瀧川紘, 高須清誠

反応と合成の進歩シンポジウム講演要旨集, 47th, 2021
Total Synthesis of (-)-Tubingensin B, An Antiviral Indole Diterpenoid

瀧川紘, 小川泰輝, 西井新, 鈴木啓介, 高須清誠

日本化学会春季年会講演予稿集(CD-ROM), 100th, 2020
カリウム塩基を用いる分子内エノラート-オレフィンメタセシス

高須清誠, 杉本和馬, 藤村駿, 紀之内颯, 宮川泰典, 山田健一, 瀧川紘, 山岡庸介

次世代を担う有機化学シンポジウム講演要旨集, 18th (CD-ROM), 2020
ベンザインとイナミドの分子内[3+2]環化付加反応

瀧川紘, 田渡司, 加藤律希, 山岡庸介, 高須清誠

反応と合成の進歩シンポジウム講演要旨集, 2020
Intramolecular [3+2] cycloaddition of benzyne with heteroatom-substituted alkynes

瀧川紘, 田渡司, 山岡庸介, 高須清誠

日本薬学会年会要旨集(CD-ROM), 140th, 2020
Total Synthesis of Cryptopleurine Derivatives and their Activity Evaluation

山岡庸介, 山川拓朗, 服部明, 瀧川紘, 高須清誠

日本薬学会年会要旨集(CD-ROM), 140th, 2020
Total synthesis of an antiviral neolignan (+)-helisorin

瀧川紘, 大山侃志, 山岡庸介, 高須清誠

日本薬学会年会要旨集(CD-ROM), 140th, 2020

Books and Other Publications

Modern Aryne Chemistry

Hiroshi Takikawa, Keisuke Suzuki (Role: Contributor, Chapter 13 Applications of arynes in natural product synthesis)

Wiley-VCH, Aug, 2021
MEDCHEM NEWS 30巻 4号 REPORT「学術シンポジウムをオンラインで開催してわかったこと」

瀧川紘 (Role: Contributor)

Nov, 2020
化学と工業 vol. 71-7：飛翔する若手研究者「ヘテロ環の特性を利用した天然物の全合成」

瀧川紘 (Role: Contributor)

日本化学会, Jul, 2018
化学と教育第65巻第7号レーダー「天然有機化合物の化学合成 ―自然界のものづくりに挑む―」

瀧川紘 (Role: Contributor)

日本化学会, 2017
有機合成実験法ハンドブック

鈴木啓介, 瀧川紘 (Role: Contributor, 第18章不安定中間体の合成と反応18.4「ベンザインおよびo-キノジメタン」)

2015
ファルマシア（6月号）トピックス「新しいペプチド修飾法：アシルほう酸MIDAエステルを用いるアミド化反応」

瀧川紘 (Role: Contributor)

日本薬学会, 2015
有機合成化学協会誌 Review de debut「シリルカチオンを鍵とする炭素-フッ素結合の活性化」

瀧川紘 (Role: Contributor)

有機合成化学協会, 2012
化学（10月号）最新のトピックス

鈴木啓介, 瀧川紘 (Role: Contributor, ペプチド合成最前線)

化学同人, 2012
Science of Synthesis; Asymmetric Organocatalysts 1

Keisuke Suzuki, Hiroshi Takikawa (Role: Contributor, 1.1.13 Carbene-Catalyzed Benzoin Reactions)

Georg Thieme, Verlag KG, 2011
Science of Synthesis Knowledge Updates

Masataka Oishi, Hiroshi Takikawa (Role: Contributor, .1.9.11 Triorganoaluminum Compounds (Update 2010))

Georg Thieme Verlag KG, 2010
化学フロンティア21 進化を続ける有機触媒

鈴木啓介, 瀧川紘 (Role: Contributor, 第12章有機触媒としての含窒素複素環式カルベン)

化学同人, 2009
有機分子触媒の新展開

鈴木啓介, 瀧川紘 (Role: Contributor, 第19章アゾリウム塩を用いる極性転換反応)

シーエムシー出版, 2006

Teaching Experience

Professional Memberships

Research Projects

Catalytic strategies for biomolecule functionalization and generation of pseudo natural products

JSPS Bilateral Joint Research Projects, Japan Society for the Promotion of Science, Aug, 2023 - May, 2025

Kounosuke Oisaki, Jaideep Saha, Hiroshi Takikawa
複合構造を有する中分子天然物を基盤とした生物活性分子の創製

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2025

瀧川紘
Synthesis of Biologically Active Alkaloids Based on a Novel Method for Constructing Bicyclic Skeletons and thier Structure-Activity Relationship

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Takikawa Hiroshi
Studies on Chemical Synthesis of Polyketide-Derived, Biologically Active Complex Natural Products

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2016 - Mar, 2021

Suzuki Keisuke
新規ビシクロ骨格構築法を基盤とした生物活性アルカロイドの合成と構造活性相関研究

Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2018 - 2020

Hiroshi Takikawa
高次構造を有するポリケチド系生理活性天然有機化合物の全合成研究

Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, 2016 - 2020

Keisuke Suzuki
Studies on the synthesis and bioactivity of ion-channel-forming heterodimeric natural products

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Takikawa Hiroshi
極性転換を鍵とする連続環化反応の開発とアンギュサイクリノン類合成への展開

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2014 - Mar, 2016

瀧川紘
Studies on the synthesis and bioactivity of ion-channel-forming heterodimeric natural products

Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2014 - 2016

Hiroshi Takikawa
極性転換を鍵とする連続環化反応の開発とアンギュサイクリノン類合成への展開

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, 2014 - 2015

Hiroshi Takikawa
Studies on the Synthesis of Highly Oxidized Complex Natural Products of Biological Significance

Grants-in-Aid for Scientific Research Grant-in-Aid for Specially Promoted Research, Grant-in-Aid for Specially Promoted Research, Japan Society for the Promotion of Science, 2011 - 2015

SUZUKI Keisuke, OHMORI Ken, ANDO Yoshio, TAKIKAWA Hiroshi, TAKAHASHI Haruko, MATSUMOTO Takashi, KUSUMI Takenori
Synthetic Studies on Dearomatized Polycyclic Natural Products

Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, Grant-in-Aid for Research Activity start-up, Japan Society for the Promotion of Science, 2009 - 2010

TAKIKAWA Hiroshi
深海微生物が産生するエンジイン化合物の合成と機能解析

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2008 - 2010

瀧川紘
核間位に不斉第4級炭素をもつ多環性化合物の合成法

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2005 - 2007

滝川紘, 瀧川紘

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Teaching Experience

Professional Memberships

Research Projects

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