PURPOSE: To quantify the area of photoreceptor damage surrounding geographic atrophy (GA) and evaluate the relationship between structural abnormalities and retinal function in eyes with GA.
DESIGN: Prospective cross-sectional study.
METHODS: Twenty-five eyes of 25 patients with GA associated with age-related macular degeneration underwent a full ophthalmologic examination, including spectral-domain optical coherence tomography (SDOCT), fundus autofluorescence (FAF), and micro-perimetry. ImageJ software was used to quantify the disruption of the ellipsoid zone on SDOCT images. Hypo fluorescent areas of the FAF images indicated areas of retinal pigment epithelium (RPE) loss. Areas of interest graded by SDOCT (photoreceptor damage) and FAF (RPE loss) were registered with microperimetry within a 6-mm circle centered on the fovea.
RESULTS: The mean area of photoreceptor damage was 7.69 +/- 5.36 mm(2), which was significantly greater than the mean area of RPE loss (4.57 +/- 4.07 mm(2), P < .001). The average retinal sensitivity of the area with photoreceptor damage outside the area of RPE loss was lower than that of the area without photoreceptor damage (6.57 +/- 4.13 dB vs 11.27 +/- 3.78 dB, P < .001). The area of photoreceptor damage surrounding the area of RPE loss was larger in eyes with pseudodrusen than in eyes without pseudodrusen (4.96 mm(2) vs 1.91 mm(2), P = .008). The only significant predictor of decreased retinal sensitivity was the area of the photoreceptor damage (P < .001).
CONCLUSIONS: Widespread photoreceptor damage surrounding sites of RPE loss occurred in eyes with GA, and it correlated with visual function. Evaluation of photoreceptor damage surrounding sites of RPE loss using OCT is important in patients with GA associated with AMD. (C) 2016 Elsevier Inc. All rights reserved.