Hye-Won Shin

Profile Information

Affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University

ORCID ID: https://orcid.org/0000-0002-9138-9554
J-GLOBAL ID: 200901051579267536
Researcher ID: P-5398-2018
researchmap Member ID: 5000091263

External link: http://www.pharm.kyoto-u.ac.jp/hshin/ShinIndex.html

Research Areas

Life sciences / Cell biology /

Papers

Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis

Natsuki Kita, Asuka Hamamoto, Siddabasave Gowda B. Gowda, Hiroyuki Takatsu, Kazuhisa Nakayama, Makoto Arita, Shu-Ping Hui, Hye-Won Shin

Journal of Lipid Research, Mar, 2024 Peer-reviewedCorresponding author
Lysosomal membrane integrity in fibroblasts derived from patients with Gaucher disease

Asuka Hamamoto, Natsuki Kita, Siddabasave Gowda B. Gowda, Hiroyuki Takatsu, Kazuhisa Nakayama, Makoto Arita, Shu-Ping Hui, Hye-Won Shin

Cell Structure and Function, 49(1) 1-10, 2024 Peer-reviewedCorresponding author
Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane

Yumeka Muranaka, Ryo Shigetomi, Yugo Iwasaki, Asuka Hamamoto, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin

Jul 3, 2023
Phosphatidylserine exposure modulates adhesion GPCR BAI1 (ADGRB1) signaling activity

Trisha Lala, Juleva K. Doan, Hiroyuki Takatsu, H. Criss Hartzell, Hye-Won Shin, Randy A. Hall

Journal of Biological Chemistry, 298(12) 102685-102685, Dec, 2022 Peer-reviewed
Regulatory Roles of N- and C-Terminal Cytoplasmic Regions of P4-ATPases

Hye-Won Shin, Hiroyuki Takatsu

Chemical and Pharmaceutical Bulletin, 70(8) 524-532, Aug 1, 2022 Lead authorCorresponding author
The interaction of ATP11C-b with ezrin contributes to its polarized localization

Hiroki Inoue, Hiroyuki Takatsu, Asuka Hamamoto, Masahiro Takayama, Riki Nakabuchi, Yumeka Muranaka, Tsukasa Yagi, Kazuhisa Nakayama, Hye-Won Shin

Journal of Cell Science, 134(20) jcs258523, Sep 16, 2021 Peer-reviewedCorresponding author
The N- or C-terminal cytoplasmic regions of P4-ATPases determine their cellular localization.

Sayuri Okamoto, Tomoki Naito, Ryo Shigetomi, Yusuke Kosugi, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin

Molecular biology of the cell, 31(19) 2115-2124, Sep 1, 2020 Peer-reviewedCorresponding author
Phosphatidylserine exposure in living cells

Hye-Won Shin, Hiroyuki Takatsu

Critical Reviews in Biochemistry and Molecular Biology, 1-13, Mar 3, 2020 Peer-reviewedCorresponding author
ATPase reaction cycle of P4‐ATPases affects their transport from the endoplasmic reticulum

Takuya Tone, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye‐Won Shin

FEBS Letters, 594(3) 412-423, Feb, 2020 Peer-reviewedCorresponding author
The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane

Masahiro Takayama, Hiroyuki Takatsu, Asuka Hamamoto, Hiroki Inoue, Tomoki Naito, Kazuhisa Nakayama, Hye-Won Shin

Journal of Cell Science, 132(17) jcs231720-jcs231720, Sep 1, 2019 Peer-reviewedCorresponding author
Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs

Bartholomew P. Roland, Tomoki Naito, Jordan T. Best, Cayetana Arnaiz-Yépez, Hiroyuki Takatsu, Roger J. Yu, Hye-Won Shin, Todd R. Graham

Journal of Biological Chemistry, 294(6) 1794-1806, Feb 8, 2019 Peer-reviewed
Phospholipid-flipping activity of P4-ATPase drives membrane curvature

Naoto Takada, Tomoki Naito, Takanari Inoue, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin

EMBO Journal, 37(9) e97705, May 2, 2018 Peer-reviewedCorresponding author
Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine)

Hye-Won Shin

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201801873R, 2018 Peer-reviewedCorresponding author
Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases

Karl-Heinz Tomaszowski, Nadja Hellmann, Viviane Ponath, Hiroyuki Takatsu, Hye-Won Shin, Bernd Kaina

Scientific Reports, 7(1), Dec, 2017 Peer-reviewed
Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation

Hiroyuki Takatsu, Masahiro Takayama, Tomoki Naito, Naoto Takada, Kazuya Tsumagari, Yasushi Ishihama, Kazuhisa Nakayama, Hye-Won Shin

NATURE COMMUNICATIONS, 8(1), Nov, 2017 Peer-reviewedCorresponding author
Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane (vol 289, pg 33543, 2014)

Hiroyuki Takatsu, Gaku Tanaka, Katsumori Segawa, Jun Suzuki, Shigekazu Nagata, Kazuhisa Nakayama, Hye-Won Shin

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(41) 21421-21421, Oct, 2016 Peer-reviewedCorresponding author
The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane

Yoshiki Tanaka, Natsuki Ono, Takahiro Shima, Gaku Tanaka, Yohei Katoh, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin

Molecular biology of the cell, 27(24) 3883-3893, 2016 Peer-reviewedCorresponding author
Alteration of transbilayer phospholipid compositions is involved in cell adhesion, cell spreading, and focal adhesion formation

Rie Miyano, Takashi Matsumoto, Hiroyuki Takatsu, Kazuhisa Nakayama, Hye-Won Shin

FEBS letters, 590(14) 2138-2145, 2016 Peer-reviewedCorresponding author
Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis

Ayako Hanai, Minako Ohgi, Chikako Yagi, Tomoko Ueda, Hye-Won Shin, Kazuhisa Nakayama

Journal of biochemistry, 159(2) 201-208, 2016 Peer-reviewed
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner (vol 286, pg 38159, 2011)

Hiroyuki Takatsu, Keiko Baba, Takahiro Shima, Hiroyuki Umino, Utako Kato, Masato Umeda, Kazuhisa Nakayama, Hye-Won Shin

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(2) 886-886, Jan, 2015 Peer-reviewedCorresponding author

Misc.

Regulation mechanism of phosphatidylserine-flippase at the plasma membrane

Hye-Won Shin, Hiroyuki Takatsu

Seikagaku, 90(4) 486-490, 2018 InvitedLead authorCorresponding author
Membrane curvature generation by transbilayer lipid flip-flop

Hye-Won Shin

36(13) 2239-2242, 2018 Invited
Roles of small GTPases and BAR domain proteins in post-Golgi membrane traffic

Hye-Won Shin, Zhiqiu Man, Kazuhisa Nakayama

Seikagaku, 84(9) 785-790, 2012 Invited
[Roles of the Arf family of small GTPases in membrane traffic]

Hye-Won Shin

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 53(16Suppl) 2058-2064, Dec, 2008 Invited
ARFによるメンブレントラフィックの調節 (特集メンブレントラフィック研究の新局面--いま明かされる細胞内輸送の仕組み)

申惠媛, 中山和久

細胞工学, 25(11) 1253-1257, Nov, 2006
Regulation of membrane trafficking by ARFs

Hye-Won Shin, Kazuhisa Nakayama

25 1254-1257, 2006 Invited
Analyses of interaction of FlP3 and FIP4 with Rab11 and ARFs and their roles in membrane traffic

Hiroshi Koga, Hye-Won Shin, Kazuhisa Nakayama

CELL STRUCTURE AND FUNCTION, 30 70-70, Jun, 2005
Coordinated recruitment of Rab5, EEA1, type II inositol 5-phosphatase and type I inositol 4-phosphtase to peripheral ruffles in serum stimulated astrocytes.

M Hayashi, H Shin, S Lacas-Gervais, M Wenk, J Modregger, A Nystuen, WN Frankel, M Solimena, M Zerial, P De Camilli

MOLECULAR BIOLOGY OF THE CELL, 15 197A-198A, Nov, 2004
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway

H Shin, M Hayashi, S Christoforidis, S Lacas-Gervais, M Wenk, M Solimena, P De Camilli, M Zerial

MOLECULAR BIOLOGY OF THE CELL, 15 198A-198A, Nov, 2004
BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: Its localization to recycling endosomes and implication in the endosome integrity

K Nakayama, H Shin

MOLECULAR BIOLOGY OF THE CELL, 15 114A-114A, Nov, 2004
BIG2 function on the endosomal compartment

Hye-Won Shin, Kazuhisa Nakayama

CELL STRUCTURE AND FUNCTION, 29 109-109, May, 2004
Vesicle fusion and tethering mechanism in Golgi complex

21 1947-1953, 2003 Invited
タンパク質の輸送と細胞内局在、タンパク質がわかる

中山和久, 申惠媛, 中村暢宏

わかる実験医学シリーズ, 56-65, 2003
Rab5-regulated phosphoinositides synthesis and turnover and its cellular function

H Shin, S Christoforidis, M Zerial

MOLECULAR BIOLOGY OF THE CELL, 13 362A-362A, Nov, 2002
gamma-Adaptin interacts directly with Rabaptin-5 through its ear domain

K Nakayama, Y Shiba, H Takatsu, HW Shin

MOLECULAR BIOLOGY OF THE CELL, 11 504A-505A, Dec, 2000

Books and Other Publications

レーニンジャ―新生化学：生化学と分子生物学の基本原理（第7版）

申惠媛 (Role: Joint translator, 第11章)

廣川書店, 2019
Dojin BioScience Series 24 メンブレントラフィック

申惠媛, 中山和久 (Role: Joint author, Arfファミリーによるメンブレントラフィックの調節)

化学同人, 2016
レーニンジャ―新生化学：生化学と分子生物学の基本原理（第6版）

申惠媛 (Role: Joint translator, 第11章)

廣川書店, 2015
プロッパー細胞生物学：細胞の基本原理を学ぶ（第1版）

申惠媛 (Role: Joint translator, 第4章、第13章)

化学同人, 2013

Major Presentations

146

Dynamic localization mechanism of lipid flippases and their functions in mammalian cells

SHIN Hye-Won

2019 Molecular and Cellular Biology Gordon Research Conference, Jul 28, 2019 Invited
Specific substrates for P4-ATPases and their regulation in mammalian cells.

SHIN Hye-Won

The 15th International Conference on Na, K-ATPase and Related Transport ATPases, Sep 24, 2017 Invited

Professional Memberships

Social Activities

88

女子中高生のためのサイエンスカフェ

Lecturer

日本学術振興会科学研究費補助金新学術領域「動的秩序と機能」領域, Mar 11, 2017

Media Coverage

Flipping lipids to deform membranes

https://www.asbmb.org/asbmb-today/science/010720/flipping-lipids-to-deform-membranes, Jan, 2020 Promotional material
Kyodai sensei theater

Kyoto Univ., 2019 Internet
Cells Flip Lipids To Bend Their Membranes

https://www.asianscientist.com/2018/04/in-the-lab/atp10a-lipid-flip-membrane-deformation/, Apr, 2018 Internet
リン脂質の移動によって細胞膜が変形するメカニズムを解明

https://www.kyoto-u.ac.jp/ja/research-news/2018-03-30, Mar, 2018 Internet
Flipping lipids for cell transport-tubules

https://www.eurekalert.org/pub_releases/2018-03/ku-flf032818.php;https://phys.org/news/2018-03-flipping-lipids-cell-transport-tubules.html;https://www.sciencedaily.com/releases/2018/03/180329141014.htm, Mar, 2018 Internet
京大、細胞膜の脂質輸送の仕組みの一端を解明

https://www.nikkei.com/article/DGXLRSP463650_X11C17A1000000/?au=0, Nov, 2017 Internet
細胞膜の脂質輸送、セロトニンやヒスタミンの受容体の仕組みの一端を解明

https://www.kyoto-u.ac.jp/ja/research-news/2017-11-17-0, Nov, 2017 Internet

Profile Information

Research Areas

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Misc.

Books and Other Publications

Major Presentations

Professional Memberships

Social Activities

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