2021年3月
The systemic antiangiogenic effect of intravitreal aflibercept injection in a mouse model of retinopathy of prematurity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 35
- 号
- 3
- 開始ページ
- e21390
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1096/fj.202002414R
Retinopathy of prematurity (ROP) is a leading cause of childhood blindness and intravitreal anti-vascular endothelial growth factor (VEGF) injection is becoming a first-line choice for treatment of ROP. However, there is a major concern that intravitreally injected anti-VEGF agents could escape from the eye into the systemic circulation and impair systemic development. Moreover, escaped anti-VEGF agents could have an effect on the retina of the fellow eye. In this study, we investigated the hematogenous effect of a single intravitreal anti-VEGF injection in a mouse model of ROP. Here, we showed that single intravitreal aflibercept injection to one eye can affect body weight gain, the fellow eye, and renal vessels, although no apparent effect was observed in brain vessels. Furthermore, this hematogenous effect was dose-dependent. Our results provide very important insights into the clinical use of anti-VEGF agents for ROP treatment.
- ID情報
-
- DOI : 10.1096/fj.202002414R
- PubMed ID : 33566381