Ihara Masafumi

J-GLOBAL         Last updated: Jul 7, 2019 at 16:14
 
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Name
Ihara Masafumi
Affiliation
National Cerebral and Cardiovascular Center Hospital
Section
Department of Neurology
Job title
Director
Degree
MD(Kyoto University), PhD(Kyoto University Graduate School of Medicine)
ORCID ID
0000-0002-7102-4048

Profile

My research interests have focussed on the pathological changes in brain blood vessels and how the alterations impact on brain health during old age. I have used brain autopsy materials and experimental rodent models to publish widely on these issues. I am currently involved in a translational research project related to regenerative therapy for stroke and a clinical trial using vasoactive drugs for mild cognitive impairment.

Research Interests

 
 

Research Areas

 
 

Published Papers

 
Tanaka M, Saito S, Inoue T, Satoh-Asahara N, Ihara M.
International Journal of Molecular Sciences   20(9)    Apr 2019   [Refereed]
Inoue T, Saito S, Tanaka M, Yamakage H, Kusakabe T, Shimatsu A, Ihara M, Satoh-Asahara N.
Proceedings of the National Academy of Sciences   116(20) 10031-10038   Apr 2019   [Refereed]
Yuriko Nakaoku, Satoshi Saito, Yumi Yamamoto, Takakuni Maki, Ryosuke Takahashi, Masafumi Ihara
International Journal of Molecular Sciences   20(10) 2539   May 2019   [Refereed]
Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada KH, Tomita T, Higashiyama A, Takahashi J, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Paré G, O'Donnell M, Ago T, Hata J, Ninomiya T, Dichgans M, Debette S, Kubo M, Koizumi A, Ihara M
Circulation   139(2) 295-298   Jan 2019   [Refereed]
Wada S, Inoue M, Matsuki T, Okata T, Kumamoto M, Tagawa N, Okamoto A, Miyata T, Ihara M, Koga M, Toyoda K.
PLOS ONE   14(3)    Mar 2019   [Refereed]
Sekikawa A, Ihara M, Lopez O, Kakuta C, Lopresti B, Higashiyama A, Aizenstein H, Chang Y.-F, Mathis C, Miyamoto Y, Kuller L, Cui C.
Current cardiology reviews   15(2) 114-135   2019   [Refereed]
Ueno Y, Tateishi Y, Doijiri R, Kuriki A, Shimizu T, Kikuno M, Shimada Y, Takekawa H, Yamaguchi E, Koga M, Kamiya Y, Ihara M, Tsujino A, Hirata K, Toyoda K, Hasegawa Y, Hattori N, Urabe T.
Atherosclerosis   284 181-186   2019   [Refereed]
Ishiyama H, Okazaki S, Saito K, Yamagami H, Ihara M.
Neurology   91(1) 41-43   2018   [Refereed]
Toyoda K, Koga M, Yamagami H, Yokota C, Sato S, Inoue M, Tanaka T, Endo K, Fujinami J, Ihara M, Nagatsuka K, Minematsu K.
Circulation Journal   82(5) 1443-1450   2018   [Refereed]
Hase Y, Horsburgh K, Ihara M, Kalaria R.N.
Journal of Neurochemistry   144(5) 617-633   2018   [Refereed]
Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Chen A, Liang D, Ennaceur A, Oakley A, Ihara M, Horsburgh K, Kalaria R.N.
Journal of Cerebral Blood Flow and Metabolism   38(1) 151-165   2018   [Refereed]
Kaide S, Ono M, Watanabe H, Kitada A, Yoshimura M, Shimizu Y, Ihara M, Saji H.
ACS Medicinal Chemistry Letters   9(5) 478-483   2018   [Refereed]
Kinoshita N, Saito K, Ihara M.
Neurology   90(12) 577   2018   [Refereed]
Kinoshita N, Saito K, Yamaguchi Y, Abe S, Wada S, Tanaka T, Kajimoto K, Yamagami H, Maruyama H, Toyoda K, Ihara M, Nagatsuka K.
Cerebrovascular Diseases   45(5-6) 258-262   2018   [Refereed]
Nakamura Y, Yamaguchi Y, Makita N, Morita Y, Ide T, Wada S, Mizoguchi T, Ikenouchi H, Miwa K, Yi K, Irie K, Shimohama S, Ihara M, Toyoda K, Koga M.
Journal of Stroke and Cerebrovascular Diseases      2019   [Refereed]
Hiroyuki Watanabe, Taisuke Ariyoshi, Akihiko Ozaki, Masafumi Ihara, Masahiro Ono, Hideo Saji
Bioorganic & Medicinal Chemistry   25(24) 6398   Dec 2017   [Refereed]
Ihara M, Washida K.
Journal of Alzheimer's Disease   62(1) 61-72   2018   [Refereed]
Maiko T. Uemura, Masafumi Ihara, Takakuni Maki, Takayuki Nakagomi, Seiji Kaji, Kengo Uemura, Tomohiro Matsuyama, Raj N. Kalaria, Ayae Kinoshita, Ryosuke Takahashi
Brain Pathology   28(4) 521-535   Jul 2018   [Refereed]
Takahashi Y, Saito S, Yamamoto Y, Uehara T, Yokota C, Sakai G, Nishida N, Takahashi R, Kalaria R.N, Toyoda K, Nagatsuka K, Ihara M, Friedland R.
Journal of Alzheimer's Disease   67(2) 621-629   2019   [Refereed]
Skrobot O.A, Love S, Kehoe P.G, O{'}Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, Ford G.A, Kalaria R.N, Pantoni L, Pasquier F, Roman G.C, Wallin A, Sachdev P, Kril J, Skoog I, Ben-Shlomo Y, Passmore A.P, Engelborghs S, Lafosse C, Bertolucci P.H, Brucki S, Caramelli P, de Toledo Ferraz Alves T.C, Bocti C, Fulop T, Hogan D.B, Hsiung G.R, Kirk A, Leach L, Robillard A, Sahlas D.J, Guo Q, Tian J, Hokkanen L, Jokinen H, Benisty S, Deramecourt V, Hauw J, Lenoir H, Tsatali M, Tsolaki M, Sundar U, Coen R.F, Korczyn A.D, Altieri M, Baldereschi M, Caltagirone C, Caravaglios G, Di Carlo A, DI Piero V, Gainotti G, Galluzzi S, Logroscino G, Mecocci P, Moretti D.V, Padovani A, Fukui T, Ihara M, Mizuno T, Kim S.Y, Akinyemi R, Baiyewu O, Ogunniyi A, Szczudlik A, Bastos-Leite A.J, Firmino H, Massano J, Verdelho A, Kruglov L.S, Ikram M.K, Kandiah N, Arana E, Barroso-Ribal J, Calatayud T, Cruz-Jentoft A.J, L{ó}pez-Pousa S, Martinez-Lage P, Mataro M, B{ö}rjesson-Hanson A, Englund E, Laukka E.J, Qiu C, Viitanen M, Biessels G.J, de Leeuw F.-E, den Heijer T, Exalto L.G, Kappelle L.J, Prins N.D, Richard E, Schmand B, van den Berg E, van der Flier W.M, Bilgic B, Allan L.M, Archer J, Attems J, Bayer A, Blackburn D, Brayne C, Bullock R, Connelly P.J, Farrant A, Fish M, Harkness K, Ince P.G, Langhorne P, Mann J, Matthews F.E, Mayer P, Pendlebury S.T, Perneczky R, Peters R, Smithard D, Stephan B.C, Swartz J.E, Todd S, Werring D.J, Wijayasiri S.N, Wilcock G, Zamboni G, Au R, Borson S, Bozoki A, Browndyke J.N, Corrada M.M, Crane P.K, Diniz B.S, Etcher L, Fillit H, Greenberg S.M, Grinberg L.T, Hurt S.W, Lamar M, Mielke M, Ott B.R, Perry G, Powers W.J, Ramos-Estebanez C, Reed B, Roberts R.O, Romero J.R, Saykin A.J, Seshadri S, Silbert L, Stern Y, Zarow C.
Alzheimer's and Dementia   13(6) 624-633   2017   [Refereed]
Offner H, Ihara M, Sch{ä}bitz W.-R, Wong P.T.-H.
Neurochemistry International   107 1-3   2017   [Refereed]
Yasuno F, Kudo T, Yamamoto A, Matsuoka K, Takahashi M, Iida H, Ihara M, Nagatsuka K, Kishimoto T.
Heliyon   3(9)    2017   [Refereed]
Kyohei Fujita, Kazutaka Sonoda, Toshiyuki Miyata, Masafumi Ihara, Kazunori Toyoda, Masatoshi Koga
Journal of Stroke and Cerebrovascular Diseases   28(1) 232-233   Jan 2019   [Refereed]
Nakaoku Y, Oishi N, Hase Y, Hase M, Saito S, Mitsueda T, Matsui M, Toyoda K, Nagatsuka K, Kalaria R.N, Fukuyama H, Ihara M, Takahashi R.
Clinical Neurology and Neurosurgery   174 68-74   2018   [Refereed]
Kinoshita N, Saito K, Tanaka T, Kajimoto K, Yamagami H, Morita Y, Ihara M, Nagatsuka K.
Neurology   89(15) 1643-1644   2017   [Refereed]
Tomari S, Tanaka T, Ihara M, Matsuki T, Fukuma K, Matsubara S, Nagatsuka K, Toyoda K.
Seizure   52 22-26   2017   [Refereed]
Shinya Tomari, Tomotaka Tanaka, Soichiro Matsubara, Kazuki Fukuma, Masafumi Ihara, Kazuyuki Nagatsuka, Kazunori Toyoda
European Neurology   256-260   2018   [Refereed]
Wada S, Yoshimura S, Inoue M, Matsuki T, Arihiro S, Koga M, Kitazono T, Makino H, Hosoda K, Ihara M, Toyoda K.
Journal of the American Heart Association   7(8)    2018   [Refereed]
Saito S, Yamamoto Y, Maki T, Hattori Y, Ito H, Mizuno K, Harada-Shiba M, Kalaria R.N, Fukushima M, Takahashi R, Ihara M.
Acta neuropathologica communications   5(1)    2017   [Refereed]
Kuriyama N, Ozaki E, Mizuno T, Ihara M, Mizuno S, Koyama T, Matsui D, Watanabe I, Akazawa K, Takeda K, Takada A, Inaba M, Yamada S, Motoyama K, Takeshita W, Iwai K, Hashiguchi K, Kobayashi D, Kondo M, Tamura A, Yamada K, Nakagawa M, Watanabe Y.
Journal of Alzheimer's Disease   61(1) 145-155   2018   [Refereed]
Yoshitaka Yamaguchi, Tomotaka Tanaka, Yoshiaki Morita, Sohei Yoshimura, Masatoshi Koga, Masafumi Ihara, Kazunori Toyoda
Cerebrovascular Diseases   15-23   2019   [Refereed]
Skrobot O.A, Black S.E, Chen C, DeCarli C, Erkinjuntti T, Ford G.A, Kalaria R.N, O{'}Brien J, Pantoni L, Pasquier F, Roman G.C, Wallin A, Sachdev P, Skoog I, Taragano F.E, Kril J, Cavalieri M, Jellinger K.A, Kovacs G.G, Engelborghs S, Lafosse C, Bertolucci P.H, Brucki S, Caramelli P, de Toledo Ferraz Alves T.C, Bocti C, Fulop T, Hogan D.B, Hsiung G.R, Kirk A, Leach L, Robillard A, Sahlas D.J, Guo Q, Tian J, Hokkanen L, Jokinen H, Benisty S, Deramecourt V, Hauw J, Lenoir H, Tsatali M, Tsolaki M, Sundar U, Coen R.F, Korczyn A.D, Altieri M, Baldereschi M, Caltagirone C, Caravaglios G, Di Carlo A, Di Piero V, Gainotti G, Galluzzi S, Logroscino G, Mecocci P, Moretti D.V, Padovani A, Fukui T, Ihara M, Mizuno T, Kim S.Y, Akinyemi R, Baiyewu O, Ogunniyi A, Szczudlik A, Bastos-Leite A.J, Firmino H, Massano J, Verdelho A, Kruglov L.S, Ikram M.K, Kandiah N, Arana E, Barroso-Ribal J, Calatayud T, Cruz-Jentoft A.J, L{ó}pez-Pousa S, Martinez-Lage P, Mataro M, B{ö}rjesson-Hanson A, Englund E, Laukka E.J, Qiu C, Viitanen M, Biessels G.J, de Leeuw F.-E, den Heijer T, Exalto L.G, Kappelle L.J, Prins N.D, Richard E, Schmand B, van den Berg E, van der Flier W.M, Bilgic B, Allan L.M, Archer J, Attems J, Bayer A, Blackburn D, Brayne C, Bullock R, Connelly P.J, Farrant A, Fish M, Harkness K, Ince P.G, Langhorne P, Mann J, Matthews F.E, Mayer P, Pendlebury S.T, Perneczky R, Peters R, Smithard D, Stephan B.C, Swartz J.E, Todd S, Werring D.J, Wijayasiri S.N, Wilcock G, Zamboni G, Au R, Borson S, Bozoki A, Browndyke J.N, Corrada M.M, Crane P.K, Diniz B.S, Etcher L, Fillit H, Greenberg S.M, Grinberg L.T, Hurt S.W, Lamar M, Mielke M, Ott B.R, Perry G, Powers W.J, Ramos-Estebanez C, Reed B, Roberts R.O, Romero J.R, Saykin A.J, Seshadri S, Silbert L, Stern Y, Zarow C, Ben-Shlomo Y, Passmore A.P, Love S, Kehoe P.G.
Alzheimer's and Dementia   14(3) 280-292   2018   [Refereed]
Abe S, Okazaki S, Tonomura S, Miyashita K, Ihara M.
Clinical Neurology   57(12) 764-768   2017   [Refereed]
Yasuno F, Kazui H, Kajimoto K, Ihara M, Morita N, Taguchi A, Yamamoto A, Matsuoka K, Takahashi M, Nakagawara J, Tsuji M, Iida H, Kishimoto T, Nagatsuka K.
International Journal of Geriatric Psychiatry   32(12) e93-e99   2017   [Refereed]
Hase Y, Craggs L, Hase M, Stevenson W, Slade J, Lopez D, Mehta R, Chen A, Liang D, Oakley A, Ihara M, Horsburgh K, Kalaria R.N.
Journal of Neuroinflammation   14(1)    2017   [Refereed]
Ihara M, Tonomura S, Yamamoto Y, Saito S.
Future Neurology   13(4) 219-224   2018   [Refereed]
Rufus O. Akinyemi, Mayowa O. Owolabi, Masafumi Ihara, Albertino Damasceno, Adesola Ogunniyi, Catherine Dotchin, Stella-Maria Paddick, Julius Ogeng'o, Richard Walker, Raj N. Kalaria
Brain Research Bulletin   145 97-108   May 2018   [Refereed]
Kitamura A, Manso Y, Duncombe J, Searcy J, Koudelka J, Binnie M, Webster S, Lennen R, Jansen M, Marshall I, Ihara M, Kalaria R.N, Horsburgh K.
Scientific Reports   7(1)    2017   [Refereed]
Morimoto T, Enmi J.-I, Hattori Y, Iguchi S, Saito S, Harada K.H, Okuda H, Mineharu Y, Takagi Y, Youssefian S, Iida H, Miyamoto S, Ihara M, Kobayashi H, Koizumi A.
Scientific Reports   8(1)    2018   [Refereed]
Wada S, Toyoda K, Sato S, Matsuki T, Okata T, Kumamoto M, Tagawa N, Inoue M, Okamoto A, Ihara M, Kitazono T, Miyata T, Koga M.
Circulation Journal   82(11) 2872-2879   2018   [Refereed]
Ihara M.
Brain and Nerve   68(7) 743-751   2016   [Refereed]
Tanaka T, Ihara M.
Neurochemistry International   107 219-228   2016   [Refereed]
Hattori Y, Enmi J.-I, Kitamura A, Yamamoto Y, Saito S, Takahashi Y, Iguchi S, Tsuji M, Yamahara K, Nagatsuka K, Iida H, Ihara M.
Journal of Neuroscience   35(9) 3915-3928   2015   [Refereed]
Holland P.R, Searcy J.L, Salvadores N, Scullion G, Chen G, Lawson G, Scott F, Bastin M.E, Ihara M, Kalaria R, Wood E.R, Smith C, Wardlaw J.M, Horsburgh K.
Journal of Cerebral Blood Flow and Metabolism   35(6) 1005-1014   2015   [Refereed]
Okazaki S, Yamagami H, Yoshimoto T, Morita Y, Yamamoto H, Toyoda K, Ihara M.
Journal of Cerebral Blood Flow and Metabolism   37(9) 3087-3090   2017   [Refereed]
Kuriyama N, Ihara M, Mizuno T, Ozaki E, Matsui D, Watanabe I, Koyama T, Kondo M, Tokuda T, Tamura A, Yamada K, Akazawa K, Takeda K, Takada A, Mizuno S, Nakagawa M, Watanabe Y.
Journal of Alzheimer's Disease   56(4) 1253-1262   2017   [Refereed]
Takahashi M, Yasuno F, Yamamuro K, Matsuoka K, Kitamura S, Yoshikawa H, Yamamoto A, Iida H, Fukuda T, Ihara M, Nagatsuka K, Kishimoto T.
Psychogeriatrics   19(3) 276-281   2018   [Refereed]
Watanabe H, Ono M, Iikuni S, Kimura H, Okamoto Y, Ihara M, Saji H.
RSC Advances   5(2) 1009-1015   2015   [Refereed]
Hattori Y, Kitamura A, Tsuji M, Nagatsuka K, Ihara M, Neuroscience letters, vol. 581, pp. 1-6
581 1-6   Oct 2014   [Refereed]
Hattori Y, Kitamura A, Tsuji M, Nagatsuka K, Ihara M, Neuroscience letters, 2014, vol. 581, pp. 1-6

Misc

 
Ikenouchi H, Washida K, Yoshimoto T, Fukuma K, Saito S, Inoue Y, Matsuda H, Ihara M.
Journal of Stroke and Cerebrovascular Diseases      May 2019   [Refereed]
Wada S, Koga M, Makita N, Nakamura Y, Miwa K, Ide T, Yi K, Mizoguchi T, Yamaguchi Y, Ihara M, Toyoda K.
Journal of Stroke and Cerebrovascular Diseases      May 2019   [Refereed]
Higashida K, Tanaka T, Yamagami H, Tomari S, Fukuma K, Okuno Y, Abe S, Nagatsuka K, Toyoda K, Ihara M.
Clinical Neurology   58(4) 217-222   2018   [Refereed]
Atticus H. Hainsworth, Atticus H. Hainsworth, Stuart M. Allan, Johannes Boltze, Johannes Boltze, Catriona Cunningham, Chad Farris, Chad Farris, Elizabeth Head, Masafumi Ihara, Jeremy D. Isaacs, Jeremy D. Isaacs, Raj N. Kalaria, Saskia A M J Lesnik Oberstein, Mark B. Moss, Mark B. Moss, Björn Nitzsche, Björn Nitzsche, Björn Nitzsche, Gary A. Rosenberg, Julie W. Rutten, Julie W. Rutten, Melita Salkovic-Petrisic, Aron M. Troen
BMC Medicine   15    Jan 2017
© 2017 The Author(s).Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models r...
Makiko Ohshima, Akihiko Taguchi, Yoshiaki Sato, Yuko Ogawa, Satoshi Saito, Kenichi Yamahara, Masafumi Ihara, Mariko Harada-Shiba, Tomoaki Ikeda, Tomohiro Matsuyama, Masahiro Tsuji
Developmental Neuroscience      Jan 2017
© 2017 S. Karger AG, BaselSeveral cell therapies have been explored as novel therapeutic strategies for neonatal encephalopathy because the benefits of current treatments are limited. We previously reported that intravenous administration of human...

Research Grants & Projects

 
AMED: Project Promoting Clinical Trials for Development of New Drugs
Project Year: Apr 2019 - Mar 2023    Investigator(s): Ihara Masafumi
AMED: Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus
Project Year: Apr 2019 - Mar 2022    Investigator(s): Ihara Masafumi
Ministry of Health, Labour and Welfare: Grant-in-Aid for Scientific Research(B)
Project Year: Apr 2017 - Mar 2021    Investigator(s): Ihara Masafumi
AMED: International Collaborative Research Program: Strategic International Collaborative Research Program (SICORP)
Project Year: Jun 2017 - May 2020    Investigator(s): Ihara Masafumi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2011 - 2011    Investigator(s): Masafumi IHARA
Skin fibroblasts were isolated from three CADASIL patients with different mutations in Notch 3 gene. Three lines of iPS cells have been established by using the fibroblasts derived from one patient with CADASIL and endothelial cells and vascular s...