論文

査読有り
2012年

Reduced expression of cytokeratin 4 and 13 is a valuable marker for histologic grading of esophageal squamous intraepithelial neoplasia

Journal of Medical and Dental Sciences
  • Masaki Takashima
  • ,
  • Hiroshi Kawachi
  • ,
  • Tsukasa Yamaguchi
  • ,
  • Yutaka Nakajima
  • ,
  • Keisuke Kitagaki
  • ,
  • Masaki Sekine
  • ,
  • Tadatsune Iida
  • ,
  • Kosuke Takemura
  • ,
  • Tatsuyuki Kawano
  • ,
  • Yoshinobu Eishi

59
1
開始ページ
17
終了ページ
28
記述言語
英語
掲載種別
研究論文(学術雑誌)

Histologic evaluation of low-grade or high-grade intraepithelial neoplasia (LG-IN or HG-IN) of the esophagus is important for estimating the risk of progression to invasive carcinoma. Discrimination between LG-IN and HG-IN, or neoplasia and nonneoplastic lesion (NNL), however, is occasionally difficult. This study was designed to evaluate whether cytokeratin expression can be used for discrimination of these lesions. Esophageal Iodine-unstained lesions (n=154), less than 10 mm, were classified into HG-IN, LG-IN, and NNL. These lesions together with 154 foci of normal esophageal epithelium (NEE) were examined by immunohistochemistry for cytokeratins (CK4 and CK13), p53 overexpression, and the MIB-1 labeling index. The ratios of CK4- and CK13-positive staining were scored from 1 to 3. The CK4- and CK13-positive staining ratios were decreased in NNL (73% and 78%), LG-IN (55% and 69%), and HG-IN (33% and 48%), compared to NEE (91% and 95%). The differences between LG-IN and HGIN, neoplasia and NNL, and among these three lesions and NEE were statistically significant (p &lt
0.005). The cytokeratin scores correlated with the MIB-1 labeling index (both: p &lt
0.0001), but not with p53 overexpression. CK4 and CK13 immunohistochemistry could be an objective method for evaluating the risk for progression to invasive carcinoma.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23896961

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