論文

国際誌
2020年8月

The Impact of Histological Variant on Oncological Outcomes in Patients With Urothelial Carcinoma of the Bladder Treated With Radical Cystectomy.

Anticancer research
  • Kenshiro Takemoto
  • ,
  • Jun Teishima
  • ,
  • Yuki Kohada
  • ,
  • Kenichiro Ikeda
  • ,
  • Hirotaka Nagamatsu
  • ,
  • Akihiro Goriki
  • ,
  • Shogo Inoue
  • ,
  • Tetsutaro Hayashi
  • ,
  • Mitsuru Kajiwara
  • ,
  • Akio Matsubara

40
8
開始ページ
4787
終了ページ
4793
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.21873/anticanres.14481

BACKGROUND/AIM: Bladder cancer with histological variant (HV) has different morphological features from usual urothelial carcinoma (UC). The aim of this study was to evaluate the oncological outcomes of HV in patients with bladder cancer. PATIENTS AND METHODS: We retrospectively evaluated data from 102 patients with UC of the bladder treated with radical cystectomy between 1998 and 2017. Pathological findings including HV were assigned by one dedicated pathologist. Recurrence-free survival (RFS) and cancer-specific survival (CSS) and overall survival (OS) were estimated by Cox regression models. RESULTS: In total, 26 patients (25.5%) had HV, and the most common variant was squamous differentiation, followed by glandular differentiation and a mixed variant consisted of squamous and glandular differentiation. The presence of HV was associated with RFS and CSS (p=0.018, p=0.036, respectively). CONCLUSION: HV has more aggressive tumor biological features compared to those with pure UC. The presence of HV was associated with poor survival.

リンク情報
DOI
https://doi.org/10.21873/anticanres.14481
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32727806
ID情報
  • DOI : 10.21873/anticanres.14481
  • PubMed ID : 32727806

エクスポート
BibTeX RIS