1996年
C-type natriuretic peptide as a possible local modulator of aldosterone secretion in bovine adrenal zona glomerulosa
Endocrinology
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- 巻
- 137
- 号
- 1
- 開始ページ
- 42
- 終了ページ
- 46
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1210/endo.137.1.8536640
- 出版者・発行元
- ENDOCRINE SOC
Although atrial and brain natriuretic peptides are well known to be involved in the regulation of cardiovascular and endocrine functions as circulating hormones, the roles of the C-type natriuretic peptide (CNP) remain unknown. We examined the effects of CNP on the secretion of aldosterone and cyclic nucleotides from bovine adrenal zona glomerulosa cells in culture. CNP produced a dose-dependent increase in the basal secretion of cGMP, with an EC50 of 3.8 x 10-10 M. CNP significantly inhibited the ACTH-induced increase in aldosterone and cAMP in a dose-related manner, with an IC50 of 3.6 x 10-10 M. Although ACTH itself did not increase cGMP secretion, the addition of CNP elicited a significant increase in cGMP secretion. The effects of CNP on the basal secretion of cGMP and the ACTH- induced secretion of aldosterone were significantly reversed by a nonpeptide natriuretic peptide receptor antagonist, HS-142-1. CNP immunoreactivity was localized in the zona glomerulosa by immunohistochemical staining. In addition, expression of CNP messenger RNA and natriuretic peptide B receptor messenger RNA was demonstrated by RT-PCR in the zona glomerulosa tissue and cells in culture. These findings suggest that CNP is a local factor regulating ACTH-induced aldosterone secretion through a guanylyl cyclase- cGMP pathway.
- リンク情報
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- DOI
- https://doi.org/10.1210/endo.137.1.8536640
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/8536640
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1996TL32300007&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=9044227265&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=9044227265&origin=inward
- ID情報
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- DOI : 10.1210/endo.137.1.8536640
- ISSN : 0013-7227
- eISSN : 1945-7170
- PubMed ID : 8536640
- SCOPUS ID : 9044227265
- Web of Science ID : WOS:A1996TL32300007