イクラミアブデルラヒムカリルイプラヒム (Ikramy Abdelraheem Khalil Ibraheem) - マイポータル

基本情報

所属: Assiut University Associate Professor

学位: PhD(Hokkaido University)

通称等の別名: I A Khalil
研究者番号: 20793508
J-GLOBAL ID: 201601000722576741
researchmap会員ID: B000266683

外部リンク

研究キーワード

論文

Optimization of siRNA delivery to target sites: issues and future directions

Expert Opin Drug Deliv. 18(11) 1053-1065 2018年11月査読有り招待有り
Synergism between a cell penetrating peptide and a pH-sensitive cationic lipid in efficient gene delivery based on double-coated nanoparticles

Ikramy A. Khalil, Seigo Kimura, Yusuke Sato, Hideyoshi Harashima

Journal of Controlled Release 275 107-116 2018年4月10日査読有り
An efficient PEGylated gene delivery system with improved targeting: Synergism between octaarginine and a fusogenic peptide

Ikramy A. Khalil, Hideyoshi Harashima

International Journal of Pharmaceutics 538(1-2) 179-187 2018年3月1日査読有り
Pretreatment of Hepatocyte Growth Factor Gene Transfer Mediated by Octaarginine Peptide-Modified Nanoparticles Ameliorates LPS/D-Galactosamine-Induced Hepatitis

Yasuhiro Hayashi, Ryoichi Mizuno, Khalil A. Ikramy, Hidetaka Akita, Hideyoshi Harashima

NUCLEIC ACID THERAPEUTICS 22(5) 360-363 2012年10月査読有り
Octaarginine- and pH sensitive fusogenic peptide-modified nanoparticles for liver gene delivery

Ikramy A. Khalil, Yasuhiro Hayashi, Ryoichi Mizuno, Hideyoshi Harashima

JOURNAL OF CONTROLLED RELEASE 156(3) 374-380 2011年12月査読有り
Cell penetrating peptide-mediated systemic siRNA delivery to the liver

Yasuhiro Hayashi, Jun Yamauchi, Ikramy A. Khalil, Kazuaki Kajimoto, Hidetaka Akita, Hideyoshi Harashima

INTERNATIONAL JOURNAL OF PHARMACEUTICS 419(1-2) 308-313 2011年10月査読有り
Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape

Ayman El-Sayed, Tomoya Masuda, Ikramy Khalil, Hidetaka Akita, Hideyoshi Harashima

JOURNAL OF CONTROLLED RELEASE 138(2) 160-167 2009年9月査読有り
Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery

Tomoko Higashi, Ikramy A. Khalil, Kaustabh K. Maiti, Woo Sirl Lee, Hidetaka Akita, Hideyoshi Harashima, Sung-Kee Chung

JOURNAL OF CONTROLLED RELEASE 136(2) 140-147 2009年6月査読有り
Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process

Hidetaka Akita, Asako Kudo, Arisa Minoura, Masaya Yamaguti, Ikrarny A. Khalil, Rumiko Moriguchi, Tomoya Masuda, Radostin Danev, Kuniaki Nagayama, Kentaro Kogure …

BIOMATERIALS 30(15) 2940-2949 2009年5月査読有り
Octaarginine- and octalysine-modified nanoparticles have different modes of endosomal escape

Ayman El-Sayed, Ikramy A. Khalil, Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima

JOURNAL OF BIOLOGICAL CHEMISTRY 283(34) 23450-23461 2008年8月査読有り
Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking

Krarny A. Khalil, Kentaro Kogure, Shiroh Futaki, Hideyoshi Harashima

INTERNATIONAL JOURNAL OF PHARMACEUTICS 354(1-2) 39-48 2008年4月査読有り
Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery

I. A. Khalil, K. Kogure, S. Futaki, S. Hama, H. Akita, M. Ueno, H. Kishida, M. Kudoh, Y. Mishina, K. Kataoka …

GENE THERAPY 14(8) 682-689 2007年4月査読有り
Positively charged polyethylenimines enhance nasal absorption of the negatively charged drug, low molecular weight heparin

Tianzhi Yang, Alamdar Hussain, Shuhua Bai, Ikramy A. Khalil, Hideyoshi Harashima, Fakhrul Ahsan

JOURNAL OF CONTROLLED RELEASE 115(3) 289-297 2006年10月査読有り
Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature.

Iwasa A, Akita H, Khalil I, Kogure K, Futaki S, Harashima H

Biochimica et biophysica acta 1758(6) 713-720 2006年6月査読有り
Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery

IA Khalil, K Kogure, H Akita, H Harashima

PHARMACOLOGICAL REVIEWS 58(1) 32-45 2006年3月査読有り
High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression

IA Khalil, K Kogure, S Futaki, H Harashima

JOURNAL OF BIOLOGICAL CHEMISTRY 281(6) 3544-3551 2006年2月査読有り
Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice.

Mudhakir D, Akita H, Khalil IA, Futaki S, Harashima H

Drug metabolism and pharmacokinetics 20(4) 275-281 2005年8月査読有り
Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation

IA Khalil, S Futaki, M Niwa, Y Baba, N Kaji, H Kamiya, H Harashima

GENE THERAPY 11(7) 636-644 2004年4月査読有り
Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy

H Akita, R Ito, IA Khalil, S Futaki, H Harashima

MOLECULAR THERAPY 9(3) 443-451 2004年3月査読有り
Lung-Endothelium-Targeted Nanoparticles Based on a pH-Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer

イクラミアブデルラヒムカリルイプラヒム

Advanced Functional Materials 査読有り

イクラミアブデルラヒムカリルイプラヒム

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